MRI: Acquisition of Photothermal Infrared Raman Microscope for High Resolution Label-free Chemical Imaging

MRI：获取光热红外拉曼显微镜进行高分辨率无标记化学成像

• 批准号: 2117225
• 负责人: Zachary Schultz
• 金额: $ 33.91万
• 依托单位: Ohio State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2117225&HistoricalAwards=false
• 关键词: MRI; Acquisition; Photothermal; Infrared; Raman

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. The Ohio State University is acquiring a photothermal Infrared-Raman microscope Fourier Transform Infrared (FTIR) imaging microscope to support the research of Zachary Schultz and colleagues Susan Olesik, Luis Rodriguez-Saona, Vicky Doan-Nguyen and Barbara Dunlap. This instrument facilitates research in the areas of biochemistry and cellular processes, electrochemistry, catalysis, and analytical chemistry. In general, the infrared and Raman spectroscopies measure the intensity of the absorbed and scattered radiation when it interacts with a sample, respectively. When radiation interacts with a compound, the molecules can begin to vibrate or rotate at certain frequencies. In a heterogeneous sample, this powerful analytical tool helps identify chemical composition qualitatively. The information can also be used to create an image of the material composition in a sample. This instrument enhances the educational, research, and teaching efforts of students at all levels in many departments as well as provides accessibility for use at nearby institutions. This award to acquire a photothermal infrared-Raman microscope is aimed at enhancing research and education at all levels, especially in chemistry and biochemistry. Studies focused on chemically imaging sub-cellular microenvironments such as drug targeting and lycopene metabolim in cellular models are pursued as are those focused on using IR photoimaging for energy storage applications such as multi-functional cathodes for electrochemical enhancement in Li-S batteries and tracking polysulfude suppresion. Other applications involving characterizing polymer nanoparticle composites and high throughput diagnostic screening are also being pursued.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由重大研究仪器项目和化学研究仪器项目共同支持。俄亥俄州立大学正在购买一台光热红外拉曼显微镜傅里叶变换红外 (FTIR) 成像显微镜，以支持 Zachary Schultz 及其同事 Susan Olesik、Luis Rodriguez-Saona、Vicky Doan-Nguyen 和 Barbara Dunlap 的研究。该仪器有助于生物化学和细胞过程、电化学、催化和分析化学领域的研究。一般来说，红外光谱和拉曼光谱分别测量与样品相互作用时吸收的辐射和散射的辐射的强度。当辐射与化合物相互作用时，分子会开始以特定频率振动或旋转。在异质样品中，这种强大的分析工具有助于定性识别化学成分。该信息还可用于创建样品中材料成分的图像。该工具增强了许多院系各级学生的教育、研究和教学工作，并为附近机构提供了使用便利。该奖项旨在获得光热红外拉曼显微镜，旨在加强各个层面的研究和教育，特别是化学和生物化学领域。研究重点是对亚细胞微环境进行化学成像，例如细胞模型中的药物靶向和番茄红素代谢，以及将红外光成像用于储能应用的研究，例如用于锂硫电池电化学增强的多功能阴极和追踪多硫化物镇压。涉及聚合物纳米粒子复合材料表征和高通量诊断筛选的其他应用也在寻求中。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优点和更广泛的影响审查标准进行评估，被认为值得支持。