MRI: Acquisition of a High-Resolution Accurate-Mass Orbitrap LC-MS System at Montclair State University

MRI：在蒙特克莱尔州立大学购置高分辨率精确质量 Orbitrap LC-MS 系统

• 批准号: 2116596
• 负责人: Jinshan Gao
• 金额: $ 45万
• 依托单位: Montclair State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2116596&HistoricalAwards=false
• 关键词: MRI; Acquisition; Resolution; Accurate; Mass

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Montclair State University is acquiring a benchtop high-resolution accurate-mass ultrahigh-pressure liquid chromatograph tandem mass spectrometry (UPLC-MS/MS) system with an orbitrap analyzer to support Dr. Jinshan Gao and colleagues Meiyin Wu, Nina Goodey, Yang Deng and David Rotella. In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species in complex samples. An instrument with a liquid chromatograph provides additional structural identification power by separating mixtures of compounds before they reach the mass spectrometer. The tandem capabilities, which couples together two mass analyzers, increase the ability of the mass spectrometer to analyze chemical samples. The acquisition strengthens the research infrastructure at this Hispanic Serving Institution and regional area. The instrument broadens participation by involving diverse students with this modern analytical technique. It is also used by collaborators at the New Jersey Institute of Technology, Fairleigh Dickinson University and Rutgers University.The award of the UPLC-MS/MS (Ultra-high performance liquid chromatography/two dimensional mass spectrometry) system is aimed at enhancing research and education at all levels. It is especially useful for quantifying and characterizing glycan, proteins and glycoproteins as well as identifying polycyclic aromatic hydrocarbons, cyanotoxin, lipids and biopolymers. The instrumentation is also used for characterizing potential drug candidates and their metabolites and for the identification of and quantification of emerging contaminants and their transformation products in water and wastewater. The instrument also serves researchers characterizing genotoxic impurities in drug substances and other products.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器项目支持。蒙特克莱尔州立大学正在采购一台配备轨道阱分析仪的台式高分辨率精确质量超高压液相色谱串联质谱 (UPLC-MS/MS) 系统，以支持 Jinshan Gau 博士及其同事 Meiyin Wu、Nina Goodey、Yang Deng 和大卫·罗特拉.一般来说，质谱 (MS) 是用于识别和表征复杂样品中少量化学物质的关键分析方法之一。 带有液相色谱仪的仪器通过在化合物混合物到达质谱仪之前对其进行分离来提供额外的结构识别能力。串联功能将两个质量分析仪连接在一起，提高了质谱仪分析化学样品的能力。此次收购加强了该西班牙裔服务机构和地区的研究基础设施。该仪器通过让不同的学生参与这种现代分析技术来扩大参与范围。新泽西理工学院、费尔利狄金森大学和罗格斯大学的合作者也使用该系统。UPLC-MS/MS（超高效液相色谱/二维质谱）系统获奖旨在加强研究和各级教育。它对于定量和表征聚糖、蛋白质和糖蛋白以及识别多环芳烃、氰毒素、脂质和生物聚合物特别有用。 该仪器还用于表征潜在候选药物及其代谢物，以及对水和废水中新出现的污染物及其转化产物进行识别和定量。该仪器还为研究人员表征原料药和其他产品中的基因毒性杂质提供服务。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Development of mass spectrometric glycan characterization tags using acid‐base chemistry and/or free radical chemistry

使用酸碱化学和/或自由基化学开发质谱聚糖表征标签

• DOI: 10.1002/mas.21810
• 发表时间: 2022-09
• 期刊: Mass Spectrometry Reviews
• 影响因子: 6.6
• 作者: Murtada, Rayan;Finn, Shane;Gao, Jinshan
• 通讯作者: Gao, Jinshan

Cyclic sulfones from double conjugate addition of Rongalite

来自雕白粉双共轭加成的环状砜

• DOI: 10.1080/00397911.2023.2222316
• 发表时间: 2023-06-09
• 期刊: Synthetic Communications
• 影响因子: 2.1
• 作者: Melina Goga;Haonan Zong;Jazmine Prana;Rudolph Michel;Antonia Muro;Elana Rubin;Janet Brenya;M. Bebbington
• 通讯作者: M. Bebbington

Mechanistic Study into Free Radical-Activated Glycan Dissociations through Isotope-Labeled Cellobioses

通过同位素标记的纤维二糖进行自由基激活聚糖解离的机理研究

• DOI: 10.1021/acs.analchem.2c04649
• 发表时间: 2023-01
• 期刊: Analytical Chemistry
• 影响因子: 7.4
• 作者: Fabijanczuk, Kimberly;Yu, Zaikuan Josh;Bakestani, Rose M.;Murtada, Rayan;Denton, Nicholas;Gaspar, Kaylee;Otegui, Tara;Acosta, Jose;Kenttämaa, Hilkka I.;Eshuis, Henk;et al
• 通讯作者: et al