CAREER: Harnessing continuous growth mechanism to synthesize water-soluble magnetic nanoparticles for magnetic particle imaging

职业：利用连续生长机制合成用于磁性粒子成像的水溶性磁性纳米粒子

• 批准号: 2144790
• 负责人: Yongfeng Zhao
• 金额: $ 50.86万
• 依托单位: Jackson State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2144790&HistoricalAwards=false
• 关键词: CAREER; Harnessing; continuous; growth; mechanism

Non-technical summary: This CAREER award supported by the Biomaterials program in the Division of Materials Research aims to understand the continuous growth mechanism of water-soluble magnetic nanoparticles (MNPs) and harness the growth mechanism to synthesize MNPs for magnetic particles imaging (MPI) application. The project serves the national interest by promoting the progress of science and advancing public health. The MPI is a promising and novel imaging modality because it can generate positive contrast signals directly from MNPs without using harmful ionizing radiation. The MPI has unlimited tissue penetration depth, low background signals, and high sensitivity. Nevertheless, the MPI is currently not available for clinical applications. One major obstacle is a lack of MPI-specific MNPs as tracers. High-performance MNPs are critical to materialize the potential of MPI in clinical translation. This project is inspired by Professor Yongfeng Zhao’s pilot study demonstrating that water-soluble MNPs can be synthesized in a continuous growth manner. The resulting MNPs show high MPI performance. However, the mechanism of the continuous growth is still unknown, and the correlation between water-soluble MNPs and MPI performance is not established. Addressing these questions will accelerate the design, synthesis, and manufacturing of high-performance MNPs for MPI. The knowledge obtained from this project will stimulate the controlled synthesis of water-soluble MNPs and clear the roadblock for the application of MPI in healthcare. This project will integrate the proposed research activities with education plans to train underrepresented students for advanced degrees. The outreach plan is to disseminate the research findings to the general public during the annual Science Maker event in the Mississippi Museum of National Science. Technical summary:The overarching goal of this proposal is to obtain a holistic molecule-level understanding of the continuous growth mechanism of water-soluble magnetic nanoparticles (MNPs) in polyols, aimed to enhance magnetic particles imaging (MPI) performance of MNPs. The research project is meaningful because MPI is an emerging tracer imaging modality that can overcome many limitations of existing imaging techniques. The properties of MNPs dictate their sensitivity and resolution, which are essential for the further application of MPI. To achieve this overarching goal, this project is designed to 1) explore the continuous growth mechanism for controlled synthesis of water-soluble MNPs; 2) unravel a living growth profile of MNPs in polyols; 3) manipulate the reaction parameters for the synthesis of water-soluble MNPs; 4) expand the mechanism to synthesize water-soluble MNPs with dopants; and 5) study the MPI properties of MNPs synthesized in polyols. This project will accelerate the selection, synthesis, and manufacturing of high-performance MNPs for MPI. The education plan is to integrate this research project with an education initiative that is designed to systematically train minority undergraduate students in the STEM area at Jackson State University (JSU) to obtain advanced degrees. The project will be integrated with a course offered at JSU through the Brookhaven National Laboratory (BNL). JSU students will interact with research scientists from BNL and learn state-of-the-art technologies on materials characterization. This research will be presented as part of the “You Be The Chemist” competition and help foster and enhance the passion for STEM among middle school students.This project is jointly funded by the Biomaterials program and the Established Program to Stimulate Competitive Research (EPSCoR).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

非技术摘要：该职业奖由材料研究部生物材料计划支持，旨在了解水溶性磁性纳米粒子（MNP）的持续生长机制，并利用生长机制合成用于磁性粒子成像（MPI）的MNP该项目通过促进科学进步和促进公众健康来服务于国家利益，因为它可以直接从 MNP 产生正对比信号，而无需使用有害的电离辐射。 MPI 具有无限的组织穿透深度、低背景信号和高灵敏度，然而，MPI 目前尚无法用于临床应用，因为高性能 MNP 是实现 MPI 的关键。该项目的灵感来自于赵永峰教授的初步研究，该研究表明水溶性MNP可以以连续生长的方式合成，但其连续生长的机制却有限。增长仍然未知，并且水溶性 MNP 和 MPI 性能之间的相关性尚未建立。解决这些问题将加速 MPI 的高性能 MNP 的设计、合成和制造。从该项目中获得的知识将刺激受控。水溶性 MNP 的合成并清除 MPI 在医疗保健领域的应用障碍。该项目将把拟议的研究活动与教育计划相结合，以培训代表性不足的学生获得高级学位。外展计划旨在向公众传播研究成果。期间密西西比国家科学博物馆的年度科学创客活动技术摘要：该提案的总体目标是获得对多元醇中水溶性磁性纳米粒子（MNP）的连续生长机制的整体分子水平了解。该研究项目意义重大，因为 MPI 是一种新兴的示踪成像模式，可以克服现有成像技术的许多限制，这决定了其灵敏度和分辨率。为了实现这一总体目标，该项目旨在 1) 探索水溶性 MNP 的控制合成的连续生长机制；2) 揭示 MNP 在多元醇中的活性生长曲线；3) 控制反应参数。用于合成水溶性MNP；4）扩展用掺杂剂合成水溶性MNP的机制；5）研究在多元醇中合成的MNP的MPI特性。用于 MPI 的高性能 MNP 的选择、合成和制造 该教育计划旨在将该研究项目与一项旨在系统地培训杰克逊州立大学 (JSU) STEM 领域少数族裔本科生的教育计划相结合。该项目将与布鲁克海文国家实验室 (BNL) 提供的课程相结合，JSU 学生将与 BNL 的研究科学家互动，学习材料表征方面的最先进技术。作为其中的一部分提出“You Be The Chemist”竞赛，有助于培养和增强中学生对 STEM 的热情。该项目由生物材料计划和刺激竞争性研究既定计划 (EPSCoR) 共同资助。该奖项反映了 NSF 的法定使命，并具有通过使用基金会的智力优点和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

The influence of the polyol solvents on the continuous growth of water-dispersible iron oxide nanoparticles

• DOI: 10.1557/s43578-023-01236-x
• 发表时间: 2023-12
• 期刊: Journal of Materials Research
• 影响因子: 2.7
• 作者: Jing Qu;Pohlee Cheah;Daniel Adams;Charles Collen;Yongfeng Zhao

In situ formation of low-valence state cobalt cation in octahedral sites of Co9S8 for highly efficient electrocatalytic hydrogen evolution

• DOI: 10.1016/j.mtener.2024.101494
• 发表时间: 2024-01-19
• 期刊: MATERIALS TODAY ENERGY
• 影响因子: 9.3
• 作者: Tian，Bin;Cheah，Pohlee;Zhao，Yongfeng
• 通讯作者: Zhao，Yongfeng