Research Initiation Awards: Synthesis of biomimetic melanin-like multifunctional nanoparticles for pH sensitive magnetic resonance imaging and photothermal therapy

研究启动奖：用于pH敏感磁共振成像和光热治疗的仿生黑色素类多功能纳米粒子的合成

• 批准号: 1700390
• 负责人: Yongfeng Zhao
• 金额: $ 29.8万
• 依托单位: Jackson State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1700390&HistoricalAwards=false
• 关键词: Research; Initiation; Awards; Synthesis; biomimetic

The Historically Black Colleges and Universities-Undergraduate Program (HBCU-UP) Research Initiation Awards (RIAs) provide support to STEM faculty at HBCUs to pursue research at their home institution, at an NSF-funded Center, at a research intensive institution or at a national laboratory. The RIA projects are expected to help further the faculty member's research capability and effectiveness, to improve research and teaching at his or her home institution, and to involve undergraduate students in research experiences. With support from the National Science Foundation, Jackson State University (JSU) will design and develop nanoparticles which are sensitive to pH change and have biocompatibility and low toxicity and can be used for molecular imaging and therapeutics. The proposed project will strengthen the educational and research capacity at JSU, augment the ongoing research being conducted in the Department of Chemistry, and build collaborations both internally and externally. The project will allow undergraduate students to connect basic chemistry and materials science with potential application in biomedical engineering. The exposure of underrepresented minorities to cutting-edge research and instrumentation will result in students who are well-prepared for graduate school and well-qualified to compete in the Nation's STEM workforce. The goal of this project is to develop biomimetic nanoparticles to enhance magnetic resonance (MR) signals in response to pH. Specifically, this study aims to: 1) synthesize and characterize poly(N,N-dipropyldopamine) nanoparticles (PDNPs) with pH sensitive components 2) develop new schemes to modify the surface of PDNPs to improve their solubility and for further functionalization; 3) prepare multifunctional PDNPs by intrinsically chelating with iron(III); and 4) evaluate the biocompatibility of nanoparticles by incubating with living cells. The development of the PDNPs will provide a procedure to prepare melanin-like nanoparticles with pH sensitive MR properties and photothermal effect. The structural characterization of PDNPs will provide information for the mechanisms of interaction of the metal ion with catechol groups. The project will not only enhance biomedical engineering research but also provide excellent education and training opportunities for both undergraduate and graduate students at JSU. This work will be conducted in collaboration with the Washington University in St. Louis. The research and educational activities will advance the academic mission of JSU.

历史悠久的黑人学院和大学的大学生计划（HBCU-UP）研究发起奖（RIAS）为HBCUS的STEM教师提供支持，以在其家庭机构，在NSF资助的中心，在研究密集型机构或在一个研究密集型机构中进行研究。国家实验室。 RIA项目有望帮助教师的研究能力和有效性，改善其家庭机构的研究和教学，并让本科生参与研究经验。在国家科学基金会的支持下，杰克逊州立大学（JSU）将设计和开发对pH变化敏感，具有生物相容性和低毒性的纳米颗粒，可用于分子成像和治疗学。拟议的项目将增强JSU的教育和研究能力，增强化学部正在进行的研究，并在内部和外部进行合作。该项目将允许本科生将基本化学和材料科学与生物医学工程中的潜在应用联系起来。代表性不足的少数群体接触尖端的研究和仪器将导致学生为研究生院做好准备，并合格地参加美国的STEM劳动力。该项目的目的是开发仿生纳米颗粒以增强磁共振（MR）信号，以响应pH。具体而言，本研究的目的是：1）与PH敏感组件的poly（N，N，N-二酰二丙氨酸）纳米颗粒（PDNP）（PDNP）的合成和表征，具有pH敏感成分2）开发新方案以修改PDNP的表面以提高其溶解度和进一步的功能； 3）通过用铁（III）本质地螯合（III）来制备多功能PDNP； 4）通过与活细胞孵育来评估纳米颗粒的生物相容性。 PDNP的开发将提供一种程序，以制备具有pH敏感特性和光热效应的黑色素样纳米颗粒。 PDNP的结构表征将为金属离子与儿茶酚基的相互作用机理提供信息。该项目不仅将增强生物医学工程研究，而且还将为JSU的本科生和研究生提供出色的教育和培训机会。这项工作将与圣路易斯华盛顿大学合作进行。研究和教育活动将推进JSU的学术任务。