PFI-TT: Development of A Rapid and Reliable Point-of-Care Screening for Infectious Diseases (COVID-19)

PFI-TT：开发快速可靠的传染病 (COVID-19) 护理点筛查

• 批准号: 2141141
• 负责人: Jinglin Fu
• 金额: $ 25万
• 依托单位: Rutgers University Camden
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2141141&HistoricalAwards=false
• 关键词: PFI; TT; Development; Rapid; Reliable

The broader impact/commercial potential of this Partnerships for Innovation - Technology Translation (PFI-TT) project is to improve public health outcomes in combating pandemic/epidemic diseases, such as COVID-19. An urgent need exists for a rapid, cost-effective, facile and reliable assays for mass screening to control and prevent the spread of emerging pandemic diseases. The proposed project will demonstrate a mass screening method to rapidly detect viruses, which can be used to identify early infected individuals for quarantine. The proposed product can be potentially used in many settings such as test centers, clinics, school health clinics and airport controls. The project will also: offer research and internship opportunities for students from diverse backgrounds and underrepresented groups, as well as local K-12 teachers and students; entrepreneurship training for participating students; and develop new industrial-academic partnerships. This work will enable rapid and reliable point-of-care detection with benefits of affordability, simplicity and rapidity, which will reduce user onboarding time and costs.The proposed project will address the current challenge of a rapid, affordable, facile and reliable detection in molecular sensing and diagnosis. The proposed project will develop a novel mechanism of engineering smart molecular devices by integrating molecular computation with specific target recognition and signal amplification on the nanoscale. The specific goals include the development of a solution assay to rapidly detect viral RNA, and a user-friendly system for integration with a lateral-flow device. The proposed research will employ a multidisciplinary approach that combines computational design, molecular assembly and circuits, and biochemical assays.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这种伙伴关系对创新 - 技术翻译（PFI-TT）项目的更广泛的影响/商业潜力是改善打击大流行/流行病疾病（例如Covid-19）的公共卫生结果。迫切需要快速，成本效益，易于且可靠的测定法进行大规模筛查，以控制和防止新兴大流行疾病的传播。拟议的项目将展示一种大规模筛查方法，以快速检测病毒，该方法可用于鉴定早期感染的人进行隔离。拟议的产品可以在许多环境中使用，例如测试中心，诊所，学校健康诊所和机场控制。该项目还将：为来自不同背景和代表性不足的团体以及本地K-12教师和学生的学生提供研究和实习机会；为参加学生提供企业家培训；并建立新的工业学术伙伴关系。这项工作将使可靠性，简单性和速度的益处能够快速可靠的护理检测，这将减少用户的登机时间和成本。拟议的项目将解决当前在分子传感和诊断中快速，负担得起，便捷，可靠检测的挑战。拟议的项目将通过将分子计算与纳米级上的特定靶标识别和信号扩增整合到工程智能分子设备的新型机制。具体目标包括开发解决方案测定法以快速检测病毒RNA，以及与横向流动设备集成的用户友好系统。拟议的研究将采用一种多学科方法，结合了计算设计，分子组装和电路以及生化测定法。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的智力优点和更广泛影响的审查标准通过评估来进行评估的。

项目成果

Competitive aptamer switch for modulating ligand binding affinity

• DOI: 10.1016/j.aac.2023.06.004
• 发表时间: 2023-06
• 期刊: Advanced Agrochem
• 作者: Derek Puyat;Sung Won Oh;Shiming Liu;Jinglin Fu

Modulation of Enzyme Cascade Activity by Local Substrate Enrichment and Exclusion on DNA Nanostructures

通过局部底物富集和排除 DNA 纳米结构来调节酶级联活性

• DOI: 10.1021/acs.langmuir.2c02064
• 发表时间: 2022
• 期刊: Langmuir
• 影响因子: 3.9
• 作者: Wang, Zhicheng;St. Iago-Mcrae, Ezry;Ebrahimimojarad, Alireza;Won Oh, Sung;Fu, Jinglin
• 通讯作者: Fu, Jinglin