MRI: Acquisition of a CryoProbe-Enabled NMR Spectrometer for Enhanced Efficiency and Sensitivity in Chemical and Biological Research

MRI：购买支持 CryoProbe 的 NMR 波谱仪，以提高化学和生物研究的效率和灵敏度

• 批准号: 2117246
• 负责人: Thusitha Jayasundera
• 金额: $ 54.28万
• 依托单位: Boston College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2117246&HistoricalAwards=false
• 关键词: MRI; Acquisition; CryoProbe; Enabled; NMR

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Boston College is acquiring a 500 MHz nuclear magnetic resonance (NMR) spectrometer equipped with liquid nitrogen cooled probe to support the research of Professor Thusitha Jayasundera and colleagues James Morken, Jianmin Gao, Jeffery Byers and Jia Niu. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as permitting study of chemically and biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. The probe uses nitrogen-cooled radiofrequency coils that deliver a much greater sensitivity enhancement over room temperature. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument is an integral part of teaching as well as research and research training of undergraduate and graduate students in chemistry and biochemistry at this institution as well as collaborators from neighboring colleges including primarily undergraduate institutions. In addition, the instrument is part of activities involving the NSF funded Boston College Research Experience for Undergraduates (REU) program and the Paper to Plastics (P2P) summer program, as well as other outreach initiatives, such as the Women in Science and Technology (WST) program. These programs are largely composed of women, first generation students, and/or minorities that are under-represented in STEM disciplines.The award of the NMR spectrometer is aimed at enhancing research and education at all levels. It especially impacts the development of non-noble metal-based catalysts and the characterization of synthesized molecules to interrogate biomolecules that cannot be targeted pharmacologically, commonly referred as "undruggable". The instrumentation is also used for developing new synthetic methods for applications in organic chemistry and for identifying macromolecules prepared with tailor-made structures and sequences. In addition, it allows the characterization of species used in metalloradical catalysis and for understanding molecular interactions in microbiome communities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要的研究工具和化学研究工具计划共同支持。波士顿学院正在收购配备液氮冷却探针的500 MHz核磁共振（NMR）光谱仪，以支持Suchitha Jayasundera教授和同事James Morken，Jianmin Gao，Jianmin Gao，Jeffery Byers和Jia Niu的研究。该光谱仪允许在各种领域进行研究，例如加速具有重要经济意义的化学反应的领域，并允许对化学和生物学相关物种进行研究。通常，核磁共振（NMR）光谱是化学家可用于阐明分子结构的最强大工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子或固态中分子之间相互作用的动力学。该探针使用氮气冷却的射频线圈，在室温上具有更大的灵敏度增强。对于正在进行边境研究的化学家来说，获得最先进的NMR光谱仪至关重要。该乐器是该机构化学和生物化学的本科生和研究生的教学和研究培训的组成部分，以及邻近大学的合作者，包括主要是本科机构。此外，该工具是涉及NSF资助的波士顿学院大学研究经验（REU）计划（REU）计划和塑料论文（P2P）夏季计划的一部分，以及其他外展计划，例如科学技术领域的女性（WST）计划。这些计划主要由妇女，第一代学生和/或少数民族组成，这些学生在STEM学科中的代表性不足。NMR光谱仪的奖励旨在增强各级研究和教育。它尤其影响非差异金属催化剂的发展以及合成分子的表征来询问无法在药理上靶向的生物分子，通常称为“不可用”。该仪器还用于开发用于有机化学应用的新合成方法，并用于鉴定使用量身定制的结构和序列制备的大分子。此外，它允许对金属自由基催化中使用的物种进行表征，并了解微生物组社区中的分子相互作用。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的智力优点和更广泛影响的评估来支持的。

项目成果

Methane Carboxylation Using Electrochemically Activated Carbon Dioxide.

使用电化学活性二氧化碳进行甲烷羧化。

• DOI: 10.1002/anie.202305568
• 发表时间: 2023
• 期刊: Angewandte Chemie (International ed. in English)
• 作者: Yuan,Yucheng;Zhang,Yuhan;Li,Haoyi;Fei,Muchun;Zhang,Hongna;Santoro,John;Wang,Dunwei
• 通讯作者: Wang,Dunwei

Desymmetrization of Vicinal Bis(boronic) Esters by Enantioselective Suzuki-Miyaura Cross-Coupling Reaction.

• DOI: 10.1021/jacs.3c01571
• 发表时间: 2023-04
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Mingkai Zhang;Paul S Lee;C. Allais;R. Singer;J. Morken

Precision native polysaccharides from living polymerization of anhydrosugars

来自脱水糖活性聚合的精密天然多糖

• DOI: 10.1038/s41557-023-01193-2
• 发表时间: 2023
• 期刊: Nature Chemistry
• 影响因子: 21.8
• 作者: Wu, Lianqian;Zhou, Zefeng;Sathe, Devavrat;Zhou, Junfeng;Dym, Shoshana;Zhao, Zhensheng;Wang, Junpeng;Niu, Jia
• 通讯作者: Niu, Jia

Mechanism of Pd/Senphos-Catalyzed trans-Hydroboration of 1,3-Enynes: Experimental and Computational Evidence in Support of the Unusual Outer-Sphere Oxidative Addition Pathway.

• DOI: 10.1021/acs.joc.2c02841
• 发表时间: 2023-02
• 期刊: The Journal of organic chemistry
• 作者: Yuanzhe Zhang;Ziyong Wang;W. Lamine;Senmiao Xu;Bo Li;A. Chrostowska;K. Miqueu;Shih‐Yuan Liu

Metalloradical approach for concurrent control in intermolecular radical allylic C−H amination

• DOI: 10.1038/s41557-022-01119-4
• 发表时间: 2023-01
• 期刊: Nature Chemistry
• 影响因子: 21.8
• 作者: Pan Xu;J. Xie;Duo-Sheng Wang;X. Zhang