MRI: Acquisition of the First 800 MHz NMR with Cryoprobe in the State of Mississippi for Biological and Chemical Research and Teaching

MRI：在密西西比州购买第一台带有冷冻探头的 800 MHz NMR，用于生物和化学研究和教学

• 批准号: 2215258
• 负责人: Nicholas Fitzkee
• 金额: $ 220.31万
• 依托单位: Mississippi State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-10-01 至 2025-09-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2215258&HistoricalAwards=false
• 关键词: MRI; Acquisition; First; 800; MHz

An award is made to Mississippi State University (MSU) to support the acquisition of an 800 MHz nuclear magnetic resonance (NMR) spectrometer. This instrument will support researchers throughout Mississippi and the southeast, enabling new research avenues in biomolecular interactions, organometallic chemistry, and polymeric materials. This project will support a diverse community of researchers at all levels, from undergraduate students to faculty at nearby PUIs and HBCUs. Students can access the new instrument firsthand through course offerings at MSU, including “Theory of Solution NMR Spectroscopy.” Moreover, MSU’s “Environmental Chemistry” course will feature instrument installation and helium use. A total of 19 investigators, 64 graduate students, 72 undergraduate students, and 7 postdoctoral trainees will be directly and immediately impacted by this project, in addition to other users who benefit through classes and workshops offered at MSU. Many of these trainees will represent ethnic minorities or first-generation college students.The new instrument will enable biomolecular and chemical research not currently possible in Mississippi. This is because the new instrument has significantly increased sensitivity and resolution over the current instrumentation available in the region. Biological researchers will use this new NMR spectrometer (1) to explore how microorganisms attach to surfaces, (2) to understand how ion channels are regulated in the heart, (3) to characterize the mechanism of metal-ion-based gene regulation, and (4) to monitor how small molecules respond to changes in metabolism. Chemical researchers will use the instrument to develop new methods for synthesizing polymeric and organometallic materials, and the instrument includes a broadband probe for detecting nonstandard nuclei such as 27Al, 29Si, and 195Pt. Data collected on the new 800 MHz NMR will be shared broadly at scientific meetings and in peer-reviewed publications.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

向密西西比州立大学（MSU）颁发了奖励，以支持获得800 MHz核磁共振（NMR）光谱仪。该仪器将支持整个密西西比州和东南部的研究人员，从而为生物分子相互作用，有机化学和聚合物材料提供新的研究途径。该项目将支持各个级别的多元化研究人员，从本科生到附近的PUI和HBCUS的教师。学生可以通过MSU的课程提供新的仪器，包括“解决方案NMR光谱理论”。此外，MSU的“环境化学”课程将采用仪器安装和氦气使用。除其他在MSU提供的课程和研讨会上受益的其他用户外，共有19名调查人员，64名研究生，72名本科生和7名博士后学员将直接受到该项目的影响。这些受训者中有许多将代表少数民族或第一代大学生。新工具将在密西西比州实现生物分子和化学研究。这是因为与该地区可用的当前仪器相比，新仪器显着提高了灵敏度和分辨率。生物学研究人员将使用这种新的NMR光谱仪（1）来探索微生物如何附着在表面上，（2）了解如何在心脏中调节离子通道，（3）以表征基于金属离子基因的基因调节机理，以及（4）以监测小分子对代谢症的响应的反应。化学研究人员将使用该仪器来开发合成聚合物和有机材料的新方法，该仪器包括用于检测非标准核的宽带探针，例如27AL，29SI和195PT。在新的800 MHz NMR上收集的数据将在科学会议和同行评审的出版物中广泛共享。该奖项反映了NSF的法定任务，并通过使用该基金会的知识分子的优点和更广泛的影响来评估NSF的法定任务。