SBIR Phase I: A novel label-free imaging device for real-time detection of lymph nodes during laparoscopic cancer surgeries

SBIR I 期：一种新型无标记成像设备，用于腹腔镜癌症手术期间实时检测淋巴结

• 批准号: 2051771
• 负责人: Zhongming Li
• 金额: $ 25.6万
• 依托单位: CISION VISION, INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2051771&HistoricalAwards=false
• 关键词: SBIR; Phase; novel; label; free

The broader impact of this Small Business Innovation Research (SBIR) Phase I project is to enable surgeons to see lymph nodes directly during cancer surgeries to (1) improve the quality-of-care for lung cancer, rectal cancer, and some gynecological cancers; and (2) save costs for hospitals by accelerating a time-consuming and potentially inaccurate step in cancer surgeries; (3) improve hospital accreditation performance, since lymph node number is a quality metric and many hospitals fail to meet the requirements stipulated by medical authorities. Decades of clinical evidence have shown evaluating lymph nodes is linked to higher survival rates for cancer patients. This project will develop a device to be seamlessly integrated into the existing surgical protocols and used as an accessory to existing laparoscopic towers and surgical robots. Any cancer hospital will be able to purchase this device, attach it to their existing towers or surgical robots, and improve their quality of care, surgery efficiency, and accreditation performance immediately at an affordable price.The proposed project addresses a difficult and common problem in surgical oncology – finding lymph nodes in cancer surgeries. Lymph nodes are critically important in the context of cancer because they are the channels for cancers to spread. However, lymph nodes are translucent in color and surrounded by fat, also translucent, making it difficult to find them with current optical systems. This project aims to develop a label-free optical imaging device to visualize lymph nodes with high contrast in real time without any injection. The goals of this project are to (1) build an accessory device attachable to a commercially available laparoscopic tower, (2) obtain optical performance testing results from animal carcasses, and (3) obtain optical performance testing results from cadaver specimens.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业创新研究（SBIR）I期项目的更广泛影响是使外科医生能够在癌症手术期间直接看到淋巴结，以改善（1）改善肺癌，直肠癌和一些妇科癌症的护理质量； （2）通过加快癌症手术的耗时且可能不准确的步骤来节省医院的成本； （3）提高医院认证绩效，因为淋巴结数是一种质量指标，许多医院无法满足医疗当局所规定的要求。数十年的临床证据表明，评估淋巴结与癌症患者的存活率较高有关。该项目将开发一种设备，以无缝集成到现有的外科协议中，并用作现有腹腔镜塔和外科机器人的配件。任何癌症医院都将能够购买该设备，将其连接到现有的塔楼或外科机器人上，并以可承受的价格立即提高其护理质量，手术效率和认证绩效。拟议的项目解决了手术肿瘤学中的困难和常见问题 - 在癌症手术中发现淋巴结淋巴结。在癌症的背景下，淋巴结非常重要，因为它们是癌症传播的通道。然而，淋巴结的颜色是半透明的，脂肪周围也是半透明的，因此很难使用当前的光学系统找到它们。该项目旨在开发一种无标签的光学成像设备，以实时可视化具有高对比度的淋巴结，而无需注射。该项目的目标是（1）构建可连接到市售腹腔镜塔的配件设备，（2）获得动物尸体的光学性能测试结果，（3）获得Cadaver样品的光学性能测试结果。该奖项通过评估了NSF的法定任务，反映了NSF的法定任务，并通过评估了CRAFRICAIL IFFICTIAL和BRODITIAL，并诚实地对其进行了支持。