MRI: Acquisition of an Operando 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer

MRI：购买 Operando 500 MHz 核磁共振 (NMR) 波谱仪

• 批准号: 2017891
• 负责人: Charles Fry
• 金额: $ 48.9万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2017891&HistoricalAwards=false
• 关键词: MRI; Acquisition; Operando; 500; MHz

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. The University of Wisconsin Madison is acquiring a 500 MHz nuclear magnetic resonance (NMR) spectrometer equipped with a flow tube accessory and dedicated software that enable online monitoring of chemical reactions in real-time under actual experimental conditions. The instrumentation supports Professor Charles Fry and colleagues at the Wisconsin High-Pressure Reactor (WiHP-NNMR). This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as permitting study of biologically relevant species. In general, NMR spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument is an integral part of teaching as well as research and research training of undergraduate students in chemistry and biochemistry at this institution and nearby colleges such as Madison College, University of Wisconsin La Crosse, University of Wisconsin Rock County, University of Wisconsin Whitewater, Lawrence University, Maranatha Baptist University, Indiana State University and Valparaiso University. The Magnetic Resonance Facility plays an important role in strengthening the relationship between the University and Wisconsin citizens by working closely with departmental programs advocating the importance of science, research, and education to the public.The award of the NMR spectrometer is aimed at enhancing research and education at all levels. It especially impacts discovery of metal-metal bonded catalysts and carbon-hydrogen functionalization reactions. The instrumentation is also for exploring photoredox catalysis, polymer mechanochemistry and three-dimensional (3D) printing. In addition, it provides information on operando investigations of transition metal catalyzed reactions. An operando method involves spectroscopic characterization of materials undergoing reaction which is coupled simultaneously with measurement of catalytic activity and selectivity. The spectrometer is also used to develop catalysts for aerobic oxidation.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器项目支持。威斯康星大学麦迪逊分校正在采购一台 500 MHz 核磁共振 (NMR) 波谱仪，配备流管附件和专用软件，可在实际实验条件下实时在线监测化学反应。该仪器为威斯康星高压反应堆 (WiHP-NNMR) 的 Charles Fry 教授及其同事提供支持。该光谱仪允许在各种领域进行研究，例如那些加速具有重大经济意义的化学反应的领域，以及允许对生物学相关物种进行研究。一般来说，核磁共振波谱是化学家阐明分子结构最强大的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于进行前沿研究的化学家来说，使用最先进的核磁共振波谱仪至关重要。该仪器是该机构和附近大学（如麦迪逊学院、威斯康星大学拉克罗斯分校、威斯康星罗克县大学、威斯康星白水大学、劳伦斯大学、马拉纳萨浸会大学、印第安纳州立大学和瓦尔帕莱索大学。磁共振设施通过与向公众宣传科学、研究和教育重要性的部门项目密切合作，在加强大学和威斯康星州公民之间的关系方面发挥着重要作用。核磁共振波谱仪的获奖旨在加强研究和各级教育。它尤其影响金属-金属键合催化剂和碳-氢功能化反应的发现。该仪器还用于探索光氧化还原催化、聚合物机械化学和三维 (3D) 打印。此外，它还提供了有关过渡金属催化反应的操作研究的信息。操作方法涉及对发生反应的材料进行光谱表征，同时结合催化活性和选择性的测量。该光谱仪还用于开发有氧氧化催化剂。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Regiospecific Alkene Aminofunctionalization via an Electrogenerated Dielectrophile

通过电生成的介电试剂进行区域特异性烯烃氨基官能化

• DOI: 10.1021/jacs.3c01137
• 发表时间: 2023-04
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Holst, Dylan E.;Dorval, Céline;Winter, Casey K.;Guzei, Ilia A.;Wickens, Zachary K.
• 通讯作者: Wickens, Zachary K.

Variable Temperature LED–NMR: Rapid Insights into a Photocatalytic Mechanism from Reaction Progress Kinetic Analysis

变温 LED™NMR：通过反应进程动力学分析快速洞察光催化机制

• DOI: 10.1021/acs.joc.2c01479
• 发表时间: 2022-09
• 期刊: The Journal of Organic Chemistry
• 作者: Swords, Wesley B.;Chapman, Steven J.;Hofstetter, Heike;Dunn, Anna L.;Yoon, Tehshik P.
• 通讯作者: Yoon, Tehshik P.

Dual-Chain Polymerization at an Early Transition-Metal Single-Site Catalyst

早期过渡金属单中心催化剂的双链聚合

• DOI: 10.1021/acscatal.2c01240
• 发表时间: 2022-08-16
• 期刊: ACS Catalysis
• 影响因子: 12.9
• 作者: T. McDaniel;N. E. Smith;Eric S. Cueny;C. L;is;is
• 通讯作者: is