Untersuchungen zur hormonellen Modulation dopaminerger Mechanismen von impulsivem Verhalten (B03)

冲动行为的多巴胺能机制的激素调节研究（B03）

• 批准号: 244721107
• 金额: --
• 依托单位: Max-Planck-Institut für Stoffwechselforschung
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/244721107?language=en
• 关键词: Untersuchungen; zur; hormonellen; Modulation; dopaminerger

Building on the achievements of our previous work, the second phase of our project will focus on integrating the various biological factors into circuit models of interactions between homeostatic mechanisms and reward-related signals. These models will combine recent advances in generative modelling of human neuroimaging and behavioural data with genetic, metabolic, endocrine, and immunological analyses during experimental perturbations of homeostasis and reward processing. A focus will be on obtaining compact, tractable indices of network dynamics with regard to homeostatic and affective (hedonic) valence processes that govern food choice in different states of satiety.

在我们之前工作成果的基础上，我们项目的第二阶段将侧重于将各种生物因素整合到稳态机制和奖励相关信号之间相互作用的电路模型中。这些模型将把人类神经影像和行为数据的生成模型的最新进展与稳态和奖励处理的实验扰动期间的遗传、代谢、内分泌和免疫学分析相结合。重点是获得关于稳态和情感（享乐）效价过程的紧凑、易处理的网络动态指数，这些过程控制着不同饱腹感状态下的食物选择。