MRI: Acquisition of an X-band Continuous-wave Electron Paramagnetic Resonance (EPR) Spectrometer

MRI：采集 X 波段连续波电子顺磁共振 (EPR) 能谱仪

基本信息

批准号：
2019066
负责人：
Joshua Figueroa
金额：
$ 37.67万
依托单位：
University of California-San Diego
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2019066&HistoricalAwards=false
关键词：
MRI Acquisition band Continuous wave

项目摘要

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. The University of California-San Diego is acquiring an X-band continuous-wave electron paramagnetic resonance (CW-EPR) spectrometer to support Professor Joshua Figueroa and colleague, Galia Debelouchina. In general, an EPR spectrometer yields detailed information on the geometric and electronic structure of molecular and solid-state materials. It is also used to obtain information about the lifetimes of free radicals (short-lived, highly reactive species) involved in valuable chemical transformations of biological interest. The acquisition strengthens the research infrastructure at this Hispanic-Serving Institution as well as in the region. The instrument broadens participation by involving diverse groups of students in research and research training using this modern technique. It also provides training opportunities to many undergraduate and graduate students as well as postdoctoral fellows at this institution as well as several neighboring institutions such as San Diego State University and the University of San Diego. The award of the EPR spectrometer is aimed at enhancing research and education at all levels. The instrument acquisition impacts studies characterizing coordinatively-unsaturated transition metal centers. The instrumentation is used for research on the development of new methodologies to study the structure of biological macromolecules in cells and the catalytic mechanism of nitrogenase. In addition, the EPR provides information to further explore the role of paramagnetic species in natural and synthetic melanin polymers and the generation of stable radical-containing species and their reactivity towards small molecules. The EPR spectrometer is also used to inform studies of the mechanism of electron-transfer reactions. It is utilized in designing transition-metal doped metal oxide materials with precisely tunable electronic and spin-qubit array properties.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项得到了主要的研究工具和化学研究工具计划的支持。加利福尼亚大学迭戈分校正在收购X波段连续的波电子顺磁共振（CW-EPR）光谱仪，以支持Joshua Figueroa教授和同事Galia Debelouchina。通常，EPR光谱仪得出有关分子和固态材料的几何和电子结构的详细信息。它还用于获取有关自由基（短寿命，高反应性物种）的寿命的信息，涉及生物学兴趣的有价值的化学转化。此次收购加强了该西班牙裔服务机构和该地区的研究基础设施。该仪器通过使用这种现代技术参与研究和研究培训的各种学生来扩大参与。它还为该机构的许多本科生和研究生以及博士后研究员以及几个邻近机构，例如圣地亚哥州立大学和圣地亚哥大学提供培训机会。 EPR光谱仪的奖励旨在增强各个级别的研究和教育。仪器采集会影响表征协调不饱和过渡金属中心的研究。该仪器用于研究新方法的开发，以研究细胞中生物大分子的结构和氮酶的催化机理。此外，EPR还提供了信息，以进一步探索顺磁性物种在天然和合成黑色素聚合物中的作用，以及稳定的含有自由基的物种及其对小分子的反应性。 EPR光谱仪还用于为电子转移反应机理的研究提供信息。它用于设计具有精确调谐的电子和自旋量阵列特性的过渡金属掺杂金属氧化物材料。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的智力优点和更广泛的影响来通过评估来支持的。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Dynamic Nuclear Polarization Illuminates Key Protein–Lipid Interactions in the Native Bacterial Cell Envelope

动态核极化揭示了天然细菌细胞包膜中关键蛋白质与脂质的相互作用

DOI：
10.1021/acs.biochem.3c00262
发表时间：
2023
期刊：
Biochemistry
影响因子：
2.9
作者：
Kent, James E.;Ackermann, Bryce E.;Debelouchina, Galia T.;Marassi, Francesca M.
通讯作者：
Marassi, Francesca M.

A Complete Triad of Zero‐Valent 17‐Electron Monoradicals of Group 7 Elements Stabilized by m ‐Terphenyl Isocyanides

间·三联苯异氰化物稳定的第 7 族元素的完整零价 17 价电子单价基团

DOI：
10.1002/anie.202300254
发表时间：
2023
期刊：
Angewandte Chemie International Edition
影响因子：
0
作者：
Salsi, Federico;Wang, Shuai;Teutloff, Christian;Busse, Marvin;Neville, Michael L.;Hagenbach, Adelheid;Bittl, Robert;Figueroa, Joshua S.;Abram, Ulrich
通讯作者：
Abram, Ulrich

DNP-enhanced solid-state NMR spectroscopy of chromatin polymers