MRI: Acquisition of a Variable Temperature (3.8-300 K) X-Band Electron Paramagnetic Resonance Spectrometer

MRI：变温 (3.8-300 K) X 波段电子顺磁共振波谱仪的采集

• 批准号: 1920110
• 负责人: Roman Dembinski
• 金额: $ 28.98万
• 依托单位: Oakland University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1920110&HistoricalAwards=false
• 关键词: MRI; Acquisition; Variable; Temperature; 3.8

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. Professor Roman Dembinski from Oakland University and colleagues Xiangqun Zeng, Ferman Chavez, Wei Zhang and Amitava Adhikary are acquiring a variable-temperature, continuous-wave-X-band-electron paramagnetic resonance (EPR) spectrometer. In general, an EPR spectrometer yields detailed information on the geometric and electronic structure of molecular and solid-state materials. It is also used to obtain information about the lifetimes of free radicals, short-lived, highly reactive species involved in valuable chemical transformations as well as the initiation of possible pathological growth. These studies impact several areas, from the synthesis of inorganic and organic molecules to the development of new solid-state materials to compounds of magnetic and biological interest. Employing examples inspired from ongoing research, this instrument is an integral part of research and teaching at the undergraduate and graduate levels at Oakland University. Additionally, the investigators are sharing the spectrometer with many interested users from the area. The instrumentation strengthens the institution's educational mission in the chemical, biochemical, and environmental sciences, which involves students from a broad range of ethnic and cultural backgrounds in southeastern Michigan. The student users include socio-economically disadvantaged and minority students in the Detroit metropolitan area.The award of this spectrometer is aimed at enhancing research and education at all levels. The instrument acquisition is especially useful in understanding the mechanisms of reactions involving free radical damage to biomolecules and its repair and/or restitution. The instrument is also employed in investigations of the roles of metallo-peptides involved in reactive oxygen species formation and in research of feromagnetic-coupled systems for materials science. The instrumentation serves researchers studying free-radical-mediated redox processes in molecules dissolved in ionic liquids, and those trying to understand the role of free radicals such as superoxide anion radical that are related to the onset of maturity of human cataracts.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项得到了主要的研究工具和化学研究工具计划的支持。来自奥克兰大学的罗马·丹宾斯基教授和同事Xiangqun Zeng，Ferman Chavez，Wei Zhang和Amitava Adhikary正在收购可变的，连续的，连续的Wave-X-Band-band-electron-electron-electron-electron Parmagnetic Resonance（EPR）光谱仪。通常，EPR光谱仪得出有关分子和固态材料的几何和电子结构的详细信息。它还用于获取有关自由​​基的寿命，短寿命，高反应性的物种，涉及有价值的化学转化以及可能的病理生长的启动。这些研究影响了几个领域，从合成无机分子和有机分子到开发新的固态材料到磁性和生物学意义的化合物。该工具采用了正在进行的研究启发的示例，是奥克兰大学本科生和研究生级别的研究和教学的组成部分。此外，调查人员正在与该地区的许多感兴趣的用户共享光谱仪。该仪器加强了该机构在化学，生化和环境科学方面的教育使命，该使命涉及密歇根州东南部各种种族和文化背景的学生。 学生用户在底特律都会区包括社会经济处于弱势群体和少数族裔学生。该光谱仪的奖励旨在增强各级研究和教育。仪器采集在理解涉及生物分子及其修复和/或恢复反应的反应机制方面特别有用。该仪器还用于研究涉及活性氧形成的金属肽的作用，以及用于材料科学的铁磁偶联系统的研究。该仪器为研究的研究人员提供服务，研究了溶解在离子液体中的分子中的自由基介导的氧化还原过程，以及那些试图了解自由基的作用，例如超氧阴离子激进组织的作用，这些自由基激进性与人类赔偿的成熟开始有关，这些奖项反映了NSF的法定任务和综述的依据，这是通过评估的范围来进行的。

项目成果

One-electron oxidation of ds(5'-GGG-3') and ds(5'-G(8OG)G-3') and the nature of hole distribution: a density functional theory (DFT) study.

ds(5-GGG-3) 和 ds(5-G(8OG)G-3) 的单电子氧化和空穴分布的性质：密度泛函理论 (DFT) 研究。

• DOI: 10.1039/c9cp06244k
• 发表时间: 2020
• 期刊: Physical chemistry chemical physics : PCCP
• 作者: Kumar,Anil;Adhikary,Amitava;Sevilla,MichaelD;Close,DavidM
• 通讯作者: Close,DavidM

Site of Azido Substitution in the Sugar Moiety of Azidopyrimidine Nucleosides Influences the Reactivity of Aminyl Radicals Formed by Dissociative Electron Attachment.

• DOI: 10.1021/acs.jpcb.0c08201
• 发表时间: 2020-12-17
• 期刊: The journal of physical chemistry. B
• 作者: Mudgal M;Dang TP;Sobczak AJ;Lumpuy DA;Dutta P;Ward S;Ward K;Alahmadi M;Kumar A;Sevilla MD;Wnuk SF;Adhikary A
• 通讯作者: Adhikary A

Comment un électron induit un dommage oxydatif dans l’ADN

在 ADN 中对电子器件进行评论

• 发表时间: 2020
• 期刊: Les Actualités chimiques
• 作者: Ma, Jun;Denisov, Sergey;Adhikary, Amitava A;Mostafavi, Mehran
• 通讯作者: Mostafavi, Mehran

Ne-22 Ion-Beam Radiation Damage to DNA: From Initial Free Radical Formation to Resulting DNA-Base Damage.

• DOI: 10.1021/acsomega.1c01954
• 发表时间: 2021-06-29
• 期刊: ACS omega
• 影响因子: 4.1
• 作者: Kant M;Jaruga P;Coskun E;Ward S;Stark AD;Baumann T;Becker D;Adhikary A;Sevilla MD;Dizdaroglu M
• 通讯作者: Dizdaroglu M

A combinatorial approach of a polypharmacological adjuvant 2-deoxy-D-glucose with low dose radiation therapy to quell the cytokine storm in COVID-19 management

• DOI: 10.1080/09553002.2020.1818865
• 发表时间: 2020-10-05
• 期刊: INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
• 影响因子: 2.6
• 作者: Verma, Amit;Adhikary, Amitava;Papineni, Rao V. L.
• 通讯作者: Papineni, Rao V. L.