MRI: Acquisition of a Variable Temperature Electron Paramagnetic Resonance (EPR) Spectrometer

MRI：获取变温电子顺磁共振 (EPR) 能谱仪

• 批准号: 2216077
• 负责人: Craig Grapperhaus
• 金额: $ 20万
• 依托单位: University of Louisville Research Foundation Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2216077&HistoricalAwards=false
• 关键词: MRI; Acquisition; Variable; Temperature; Electron

This award is jointly supported by the Major Research Instrumentation, the Chemistry Research Instrumentation programs, and the Established Program to Stimulate Competitive Research. The University of Louisville is acquiring an upgraded X-band electron paramagnetic resonance (EPR) spectrometer to support the research of Professor Craig Grapperhaus along with colleague Xiang Zhang. This instrument facilitates research in the areas of chemistry, physical chemistry, biology, and biochemistry. An EPR spectrometer yields detailed information on electronic structure and intermolecular interactions by detecting paramagnetic species. Lifetimes of free radicals, which are short-lived, highly reactive species, and transition metal ions can be identified and quantified in a variety of materials. This instrument enhances the educational, research, and teaching efforts of students at all levels in multiple departments within the University of Louisville and at two primarily undergraduate institutions, Indiana University Southeast and Bellarmine University.The award of the EPR spectrometer is aimed at enhancing research and education at all levels, especially in areas such as carbon-free fuels, electronic and spintronic materials, pharmacological applications, and cellular stress caused by diabetes. Specifically, the instrument enables a wide range of projects including electrocatalysts with redox active ligands for small molecule activation and studies of water-soluble catalysts for green organic synthesis. Other investigations include structural biology studies of higher order DNA that is essential for cell life cycles and transcription regulation elements in gene promotor regions. It also assists in the fundamental investigations of a mitochondrial membrane protein that exhibits catalytic activity and the study of reactive oxygen species inducing cell processes. Additionally, it enables the characterization of the magnetic properties of 2D magnetic materials.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要的研究工具，化学研究工具计划以及启发竞争性研究的既定计划共同支持。路易斯维尔大学（University of Louisville）正在购买升级的X频段电子顺磁共振共鸣（EPR）光谱仪，以支持Craig Grapperhaus教授与同事Xiang Zhang的研究。该仪器促进了化学，物理化学，生物学和生物化学领域的研究。 EPR光谱仪通过检测顺磁物种提供了有关电子结构和分子间相互作用的详细信息。可以在各种材料中识别和量化自由基的寿命，这些自由基的寿命是短暂的，高反应性的和过渡金属离子。该工具增强了路易斯维尔大学多个系的各个级别的学生的教育，研究和教学工作，以及两个主要的本科机构，印第安纳大学东南部和贝拉明大学。授予EPR光谱仪旨在增强各个层次的研究和教育，尤其是在各个领域，尤其是在碳，电子和疾病学材料和药物学材料以及诸如碳，疾病和药物学材料以及诸如碳纤维的压力下，以及。具体而言，该仪器可实现各种各样的项目，包括带有氧化还原活性配体的电催化剂，用于小分子激活以及用于绿色有机合成的水溶性催化剂的研究。其他研究包括对高阶DNA的结构生物学研究，这对于基因启动子区域中的细胞生命周期和转录调节元件至关重要。它还有助于对线粒体膜蛋白的基本研究，该线粒体膜蛋白表现出催化活性以及对诱导细胞过程的活性氧的研究。此外，它可以表征2D磁性材料的磁性特性。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛影响的审查标准来评估值得支持的。