MRI: Acquisition of a Variable Temperature Electron Paramagnetic Resonance (EPR) Spectrometer

MRI：获取变温电子顺磁共振 (EPR) 能谱仪

• 批准号: 2216077
• 负责人: Craig Grapperhaus
• 金额: $ 20万
• 依托单位: University of Louisville Research Foundation Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2216077&HistoricalAwards=false
• 关键词: MRI; Acquisition; Variable; Temperature; Electron

This award is jointly supported by the Major Research Instrumentation, the Chemistry Research Instrumentation programs, and the Established Program to Stimulate Competitive Research. The University of Louisville is acquiring an upgraded X-band electron paramagnetic resonance (EPR) spectrometer to support the research of Professor Craig Grapperhaus along with colleague Xiang Zhang. This instrument facilitates research in the areas of chemistry, physical chemistry, biology, and biochemistry. An EPR spectrometer yields detailed information on electronic structure and intermolecular interactions by detecting paramagnetic species. Lifetimes of free radicals, which are short-lived, highly reactive species, and transition metal ions can be identified and quantified in a variety of materials. This instrument enhances the educational, research, and teaching efforts of students at all levels in multiple departments within the University of Louisville and at two primarily undergraduate institutions, Indiana University Southeast and Bellarmine University.The award of the EPR spectrometer is aimed at enhancing research and education at all levels, especially in areas such as carbon-free fuels, electronic and spintronic materials, pharmacological applications, and cellular stress caused by diabetes. Specifically, the instrument enables a wide range of projects including electrocatalysts with redox active ligands for small molecule activation and studies of water-soluble catalysts for green organic synthesis. Other investigations include structural biology studies of higher order DNA that is essential for cell life cycles and transcription regulation elements in gene promotor regions. It also assists in the fundamental investigations of a mitochondrial membrane protein that exhibits catalytic activity and the study of reactive oxygen species inducing cell processes. Additionally, it enables the characterization of the magnetic properties of 2D magnetic materials.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器、化学研究仪器项目和刺激竞争性研究既定项目共同支持。路易斯维尔大学正在购买一台升级的 X 波段电子顺磁共振 (EPR) 光谱仪，以支持 Craig Grapperhaus 教授和同事张翔的研究。该仪器有助于化学、物理化学、生物学和生物化学领域的研究。 EPR 波谱仪通过检测顺磁性物质来产生有关电子结构和分子间相互作用的详细信息。自由基（寿命较短、活性高的物质）和过渡金属离子的寿命可以在各种材料中进行识别和量化。该仪器增强了路易斯维尔大学多个系以及两所主要本科院校（东南印第安纳大学和贝拉明大学）各级学生的教育、研究和教学工作。EPR 光谱仪的获奖旨在加强研究和教学各级教育，特别是在无碳燃料、电子和自旋电子材料、药理学应用以及糖尿病引起的细胞应激等领域。具体来说，该仪器可实现广泛的项目，包括用于小分子活化的具有氧化还原活性配体的电催化剂以及用于绿色有机合成的水溶性催化剂的研究。其他研究包括对细胞生命周期和基因启动子区域转录调控元件至关重要的高阶 DNA 的结构生物学研究。它还有助于对具有催化活性的线粒体膜蛋白进行基础研究，以及活性氧诱导细胞过程的研究。此外，它还能够表征 2D 磁性材料的磁性。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。