CAS: Complexity-Building Reactions from Feedstock Chemicals

CAS：原料化学品产生的复杂反应

• 批准号: 1954835
• 负责人: Jeffrey Johnson
• 金额: $ 45万
• 依托单位: University of North Carolina at Chapel Hill
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1954835&HistoricalAwards=false
• 关键词: CAS; Complexity; Building; Reactions; Feedstock

With this award, the Chemical Synthesis Program of the NSF Division of Chemistry is supporting the research of Professor Jeffrey S. Johnson of the Department of Chemistry at the University of North Carolina at Chapel Hill. Professor Johnson and his research team are creating new chemical processes that provide high-value molecules from abundant feedstock chemicals (even “waste” chemicals). Sustainability is a critical challenge facing society and the field of chemistry. The focus on using abundant chemicals to access complex molecules through the creative use of catalytic processes is addressing the societal need for new pharmaceuticals and materials with sustainable sources. These studies are being paired with efforts by Professor Johnson and his research group to enhance public outreach in STEM (science, technology, engineering, and mathematics) and to support the inclusion of students from underrepresented groups in chemistry. The Johnson group has a notable track record in successfully mentoring diverse students through the doctoral program and on to leadership positions.High abundance and inexpensive starting materials such as carbon dioxide, carbon monoxide, ammonia, and aromatic compounds are often viewed as ‘dead-end’ molecules because of their stability and relative inertness. Professor Johnson and his research group are developing new reactions that will take these abundant, poorly-reactive molecules and convert them into useful synthetic building blocks. The Johnson research team is transforming achiral aromatic compounds into chiral carbocycles through catalyzed dearomatization reactions that result in cyclohexadienoid systems bearing strained fused rings, such as norcaradienes. These systems can then be used to incorporate feedstock compounds of the sort described. In this way, the Johnson group is pursuing the streamlined and stereoselective assemblies of useful advanced chiral and densely functionalized heterocyclic structures while incorporating abundant inexpensive gaseous feedstock at the same time. These activities provide an excellent training ground in synthetic chemistry for a diverse group of graduate and undergraduate students.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

有了这个奖项，NSF化学部的化学合成计划支持北卡罗来纳大学教堂山分校化学系的Jeffrey S. Johnson教授的研究。约翰逊教授和他的研究团队正在创建新的化学过程，这些化学过程可提供来自丰富的原料化学物质（甚至“废物”化学物质）的高价值分子。可持续性是社会和化学领域面临的关键挑战。通过创造性地使用催化过程来使用丰富的化学物质来获取复杂分子的重点是满足对具有可持续资源的新药物和材料的社会需求。这些研究与约翰逊教授及其研究小组的努力相结合，以增强STEM（科学，技术，工程和数学）的公共宣传，并支持从化学中代表性不足的群体中纳入学生。约翰逊集团（Johnson Group）通过博士学位和领导职位具有成功的心理潜水员学生的著作记录。高抽象和廉价的起始材料，例如二氧化碳，一氧化碳，氨和芳香化合物，通常被视为“死角”分子，因为它们的稳定性和相对惰性。约翰逊教授及其研究小组正在开发新的反应，这些反应将采用这些丰富，反应不良的分子，并将其转换为有用的合成构建基础。约翰逊研究团队正在通过催化的珍贵疗法反应将Achiral Atromation化合物转化为手性碳循环，从而导致带有紧张的融合环（例如Norcaradienes）的环己糖类系统。然后，这些系统可用于合并所述类型的原料化合物。通过这种方式，约翰逊组正在追求有用的高级手性和功能性杂环结构的流线型和立体选择性组合，同时同时结合了丰富的廉价气态原料。这些活动为一个研究生和本科生的潜水员群体提供了良好的培训基础。该奖项反映了NSF的法定任务，并通过使用基金会的知识分子优点和更广泛的影响评估标准来评估，被认为是珍贵的支持。

项目成果

Dearomative Synthesis of Chiral Dienes Enables Improved Late-Stage Ligand Diversification

• DOI: 10.1021/acs.orglett.2c00183
• 发表时间: 2022-03-11
• 期刊: ORGANIC LETTERS
• 影响因子: 5.2
• 作者: Crawford, Evan T.;Smith, Kendrick L.;Johnson, Jeffrey S.
• 通讯作者: Johnson, Jeffrey S.