Building Molecular Complexity Through Enzyme-Enabled Synthesis

通过酶合成构建分子复杂性

• 批准号: DE240100502
• 负责人: Dr Lauren Murray
• 金额: $ 29.42万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE240100502
• 关键词: Building; Molecular; Complexity; Through; Enzyme

Many valuable natural molecules are too complex to be commercially synthesised by current technologies. Despite advances in synthetic chemistry there is great need to adopt the elegant biocatalytic strategies for complex molecule synthesis found in nature, employing sophisticated enzyme catalysts. This interdisciplinary research program aims to address the shortcomings of traditional synthetic methods through the development of enzyme catalysts to rapidly generate complex molecular structures. These novel molecules can be readily converted into pharmaceuticals and agrochemicals leading to advancements in the bio-enabled production and application of organic molecules in these vital fields.

许多有价值的天然分子太复杂，无法通过当前技术在商业上综合。尽管合成化学的进步进步，但仍需要采用优雅的生物催化策略，用于使用复杂的酶催化剂，在自然界中发现的复杂分子合成。该跨学科研究计划旨在通过开发酶催化剂来迅速产生复杂的分子结构来解决传统合成方法的缺点。这些新型分子可以很容易地转化为药物和农业化学物质，从而在这些重要领域的有机分子生产和应用中进步。