RIDIR Collaborative Research: Building a Database to Determine Environmental and Familial Effects on Social and Biological Factors

RIDIR 合作研究：建立数据库以确定环境和家庭对社会和生物因素的影响

• 批准号: 1926601
• 负责人: Qian Wang
• 金额: $ 41.02万
• 依托单位: Texas A&M University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1926601&HistoricalAwards=false
• 关键词: RIDIR; Collaborative; Research; Building; Database

Drs. Qian Wang, from Texas A&M University, and an interdisciplinary team of colleagues are developing a database that integrates genetic, environmental and age-related information to study their effects on health conditions of the rhesus monkey colony at Cayo Santiago, Puerto Rico. The team brings together expertise in anthropology, biology, biomedical sciences and computer sciences. Founded in 1938, this colony is the source of a rare skeletal collection with associated details about each individual's sex, age, and pedigree (up to eight generations). Once the integrated database is available to researchers and the public, information from the Cayo Santiago rhesus colony and the derived skeletal collection will provide a powerful non-human model for studying human disease, family history, development, individual experiences, and aging. Dr. Wang and his colleagues will establish a database of Cayo Santiago monkey health for studies of the effects of environment and genetics on bone development, aging, and pathologies. The studies are based on the Cayo Santiago, Puerto Rico derived skeletal collection housed at the Caribbean Primate Research Center and New York University. Bone dimensions, bone density, body mass, tooth eruption, and observable disease conditions of the rhesus monkey will be incorporated into the database with details on each individual's sex, birth and death dates, parentage information, and social rank. Differences in skeletal characteristics over time will be assessed, as well as familial differences in health, longevity, and age-related conditions. The effects of major hurricanes on rhesus monkey development will be assessed. Database development incorporates undergraduate and dental students from diverse communities, providing unique learning opportunities. These data will establish a useful, searchable model that will be available to researchers interested in further analyses of genetic and environmental factors influencing multiple factors including health and disease.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

博士。来自德克萨斯A＆M大学的王以及同事的跨学科团队正在开发一个数据库，该数据库集成了遗传，环境和年龄相关信息，以研究其对波多黎各Cayo Santiago恒河猴猴子殖民地健康状况的影响。该团队汇集了人类学，生物学，生物医学和计算机科学方面的专业知识。 这个殖民地成立于1938年，是罕见的骨骼收集的来源，其相关细节有关每个人的性别，年龄和谱系（最多八代）。 一旦综合数据库可供研究人员和公众使用，Cayo Santiago Rhesus殖民地和衍生骨骼收集的信息将为研究人类疾病，家族史，发展，个人经验和衰老提供强大的非人类模型。 Wang博士及其同事将建立一个Cayo Santiago Monkey Health的数据库，以研究环境和遗传学对骨骼发育，衰老和病理的影响。 这些研究基于圣地亚哥的Cayo Santiago，波多黎各衍生的骨骼收藏，位于加勒比灵长类动物研究中心和纽约大学。 骨骼尺寸，骨密度，体重，牙齿喷发和可观察到的恒河猴疾病状况将被纳入数据库中，并提供有关每个人的性别，出生和死亡日期，父母育儿信息和社会等级的详细信息。 随着时间的流逝，骨骼特征的差异将被评估，以及健康，寿命和与年龄相关的状况的家族差异。 将评估主要飓风对恒河猴发展的影响。 数据库开发结合了来自不同社区的本科生和牙科学生，提供了独特的学习机会。 这些数据将建立一个有用的，可搜索的模型，该模型将对有兴趣进一步分析影响包括健康和疾病在内的遗传和环境因素进行进一步分析的研究人员可以使用。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛影响的审查标准通过评估来获得支持的。

项目成果

Coming to the Caribbean-acclimation of Rhesus macaques (Macaca mulatta) at Cayo Santiago.

来到圣地亚哥岛的加勒比海驯化恒河猴（Macaca mulatta）。

• DOI: 10.1002/ajpa.24748
• 发表时间: 2023
• 期刊: American journal of biological anthropology
• 作者: Francis,George;Wang,Qian
• 通讯作者: Wang,Qian

Building a Knowledge Model of Cayo Santiago Rhesus Macaques: Engaging Undergraduate Students in Developing Graphical User Interfaces for an NSF Funded Research Project.

构建圣地亚哥岛恒河猴的知识模型：让本科生参与为 NSF 资助的研究项目开发图形用户界面。

• 发表时间: 2023
• 期刊: Proceedings of the Second International Conference on Innovations in Computing Research (ICR’23
• 作者: Zhao, Martin Q.;Widener, Ethan R.;Francis, G.;Wang, Q.
• 通讯作者: Wang, Q.

Conceptual Design and Prototyping for a Primate Health History Model

灵长类动物健康史模型的概念设计和原型制作

• 发表时间: 2021
• 期刊: Transactions on computational science and computational intelligence
• 作者: Zhao, Martin Q;Maldonado, Elizabeth;Kensler, Terry B;Kohn, Luci AP;Guatelli-Steinberg, Debbie;Wang, Q.
• 通讯作者: Wang, Q.

Secular trend in body weight of Rhesus macaques (Macaca mulatta) at Cayo Santiago

圣地亚哥岛恒河猴（Macaca mulatta）体重的长期趋势

• 发表时间: 2021
• 期刊: American journal of physical anthropology
• 影响因子: 2.8
• 作者: Francis, George;Wang, Q.
• 通讯作者: Wang, Q.

Relationships between sex, body mass and tooth wear in Cayo Santiago rhesus monkeys (Macaca mulatta)

圣地亚哥岛恒河猴（Macaca mulatta）的性别、体重和牙齿磨损之间的关系

• 发表时间: 2021
• 期刊: American journal of physical anthropology
• 影响因子: 2.8
• 作者: Guatelli-Steinberg, Debbie;Maldonado, Elizabeth;Kensler, Terry B;Kohn, Luci AP;Zhao, Martin Q;Wang, Q.
• 通讯作者: Wang, Q.