Development of functional polymer-protein core-shell nanoparticles

功能性聚合物-蛋白质核-壳纳米粒子的开发

基本信息

批准号：
1307319
负责人：
Qian Wang
金额：
$ 39万
依托单位：
University of South Carolina at Columbia
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2013
资助国家：
美国
起止时间：
2013-10-01 至 2017-09-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1307319&HistoricalAwards=false
关键词：
Development functional polymer protein core

项目摘要

In this project funded by the Macromolecular, Supramolecular, and Nanochemistry (MSN) program in the Division of Chemistry, Qian Wang of the University of South Carolina will develop a new strategy to synthesize functional polymer-protein core-shell nanoparticles. Specifically, the project will focus on the design and synthesis of biocompatible and biodegradable polymers for the fabrication of polymer-protein core-shell nanoparticles. The assembly process will be characterized quantitatively using solution small angle neutron scattering, fluorescent microscopy, isothermal titration calorimetry and quartz crystal microbalance techniques. Finally, in order to validate the synthetic chemistry, a model core-shell nanoparticle system will be created for delivery and release of a molecular payload. The broader impacts of the project involve the interdisciplinary training of project participants, ranging from high school students to undergraduate and graduate students. The project will enable them to develop advanced research skills and provide international networks that will serve students well in their future careers under the ever-growing situation of economic globalization. This research project will uncover new ways to create small particles with nanometer dimensions that are hybrids of synthetic materials and proteins. Such knowledge is essential for the development of low-cost, structurally well-defined particles that could be used for applications ranging from drug delivery, to protein pharmaceuticals, and to the stabilization and support of enzyme catalysts.

在该项目由大分子，超分子和纳米化学（MSN）计划资助的项目中，南卡罗来纳大学的量将制定一项新战略，以合成功能性聚合物 - 蛋白质 - 蛋白质核心 - 核心 - 核心 - 壳壳纳米粒子。具体而言，该项目将集中于生物相容性和可生物降解聚合物的设计和合成，用于制造聚合物 - 蛋白质核心壳壳纳米颗粒。组装过程将使用溶液定量表征小角度中子散射，荧光显微镜，等温滴定量热法和石英晶体微平衡技术。最后，为了验证合成化学，将创建一个模型核心纳米颗粒系统，以递送和释放分子有效载荷。该项目的更广泛影响包括对项目参与者进行跨学科培训，从高中生到本科和研究生。该项目将使他们能够发展先进的研究技能，并提供国际网络，这些网络将在不断增长的经济全球化状况下为未来职业的学生提供良好的服务。该研究项目将发现新的方法来创建具有合成材料和蛋白质杂种的纳米尺寸的小颗粒。这种知识对于开发低成本，结构良好的颗粒的发展至关重要，这些颗粒可用于从药物递送到蛋白质药物以及稳定和支持酶催化剂的应用。