REU Site: IUPUI REU Program in Mathematics with Applications to Medicine, Neuroscience, and Engineering

REU 网站：IUPUI REU 数学及其在医学、神经科学和工程中的应用项目

• 批准号: 1852146
• 负责人: Julia Arciero
• 金额: $ 23.04万
• 依托单位: Indiana University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1852146&HistoricalAwards=false
• 关键词: REU; Site; IUPUI; Program; Mathematics

The REU Program at Indiana University-Purdue University Indianapolis (IUPUI) will provide eight undergraduate students from across the United States with the opportunity to conduct mathematics research applied to medicine, neuroscience, and engineering. The students will spend seven weeks during the summer in Indianapolis working with faculty mentors from the IUPUI Department of Mathematical Sciences and Department of Mechanical Engineering on one of four main projects: modeling treatment strategies for heart transplant patients, investigating the influence of addictive drugs on the brain, simulating cancer cell motion, and designing novel topology optimization methods for impact-protective structures. Research in mathematics provides students with important skills that they can use to analyze and solve problems in all disciplines and environments. This program is extremely beneficial to undergraduate students because it introduces students to interdisciplinary research, it connects students with professors who will become important mentors and role models in their lives, and it yields new results that will impact multiple scientific disciplines, including immunology, oncology, emergency medicine, and mechanical engineering. As the world continues to make technological advances at an incredibly rapid pace, there is an increased need for scientists and engineers. Exposing the IUPUI REU Program students to applied mathematics research will encourage many of these students to pursue careers in STEM-related fields and will ultimately provide the United States with individuals who possess a deep knowledge of modern science and who are well equipped to have an impact on science and technology in the public and private sectors. The REU projects address new and open problems in applied mathematics, and the progress that the students make on the respective projects will advance research in transplant immunology, fluid dynamics, neuroscience, and mechanical engineering. Students participating in the first REU project will work closely with a mathematician and immunologist to design, analyze, and validate a mathematical model of mouse heart transplantation and potential adoptive transfer therapeutic approaches. The second project involves the development of a mathematical model of cancer cell motion in microfluidic devices and vessels in order to determine possible methods for decreasing cancer cell metastasis. In the third project, the students will develop a mathematical model for mesocortical representations of choices and the influence of drugs of abuse (mainly alcohol) on them. Behavioral and in vivo electrophysiological approaches will be combined with computational modeling to integrate data obtained in different experimental setups to reveal mechanisms of alcohol influence and to make and test predictions in silico. A fourth project will focus on the analytical derivation and numerical implementation of novel topology optimization methods and their application to the design of impact-protective structures. Students will apply a numerical approach to determine the most effective material distribution for synthesizing complex, high-performance structures without any preconceived shape.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

印第安纳大学-普渡大学印第安纳波利斯分校 (IUPUI) 的 REU 项目将为来自美国各地的八名本科生提供进行应用于医学、神经科学和工程的数学研究的机会。暑假期间，学生们将在印第安纳波利斯度过七周的时间，与 IUPUI 数学科学系和机械工程系的导师合作，开展四个主要项目之一：为心脏移植患者建立治疗策略模型、研究成瘾药物对成瘾药物的影响。大脑，模拟癌细胞运动，并为冲击防护结构设计新颖的拓扑优化方法。 数学研究为学生提供了重要的技能，他们可以使用这些技能来分析和解决所有学科和环境中的问题。 该项目对本科生极为有益，因为它向学生介绍跨学科研究，将学生与将成为他们生活中重要导师和榜样的教授联系起来，并且产生的新成果将影响多个科学学科，包括免疫学、肿瘤学、急诊医学和机械工程。 随着世界继续以令人难以置信的速度取得技术进步，对科学家和工程师的需求不断增加。 让 IUPUI REU 项目的学生接触应用数学研究将鼓励其中许多学生从事 STEM 相关领域的职业，并最终为美国提供拥有深厚现代科学知识并有能力产生影响的人才公共和私营部门的科学技术。 REU 项目解决了应用数学中的新的开放性问题，学生在各自项目上取得的进展将推动移植免疫学、流体动力学、神经科学和机械工程的研究。 参与第一个 REU 项目的学生将与数学家和免疫学家密切合作，设计、分析和验证小鼠心脏移植的数学模型和潜在的过继转移治疗方法。 第二个项目涉及开发微流体装置和血管中癌细胞运动的数学模型，以确定减少癌细胞转移的可能方法。 在第三个项目中，学生们将开发一个数学模型，用于表达选择的中皮层以及滥用药物（主要是酒精）对他们的影响。 行为和体内电生理学方法将与计算模型相结合，整合在不同实验设置中获得的数据，以揭示酒精影响的机制，并在计算机中进行和测试预测。 第四个项目将重点关注新型拓扑优化方法的分析推导和数值实现及其在冲击防护结构设计中的应用。学生将应用数值方法来确定最有效的材料分布，以合成复杂的高性能结构，而无需任何先入为主的形状。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查进行评估，被认为值得支持标准。

项目成果

Predicting Experimental Sepsis Survival with a Mathematical Model of Acute Inflammation

用急性炎症数学模型预测实验性脓毒症生存率

• DOI: 10.3389/fsysb.2021.755913
• 发表时间: 2021-11
• 期刊: Frontiers in Systems Biology
• 作者: Barber, Jared;Carpenter, Amy;Torsey, Allison;Borgard, Tyler;Namas, Rami A.;Vodovotz, Yoram;Arciero, Julia
• 通讯作者: Arciero, Julia