REU Site: IUPUI REU Program in Mathematics with Applications to Medicine, Neuroscience, and Fluid Dynamics

REU 网站：IUPUI REU 数学及其在医学、神经科学和流体动力学应用中的项目

• 批准号: 2150108
• 负责人: Julia Arciero
• 金额: $ 25.92万
• 依托单位: Indiana University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2150108&HistoricalAwards=false
• 关键词: REU; Site; IUPUI; Program; Mathematics

This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2). The REU Program at Indiana University-Purdue University Indianapolis (IUPUI) will provide eight undergraduate students from across the United States with the opportunity to conduct mathematics research applied to medicine, fluid dynamics, and neuroscience. The students will spend eight weeks during the summer in Indianapolis working with faculty mentors from the IUPUI Department of Mathematical Sciences. This REU Site program will introduce students to interdisciplinary research experience and yield new research outcomes that will impact multiple scientific disciplines. Specifically, the participants will work on one of four main projects: modeling treatment strategies for heart transplant patients, investigating the influence of addictive drugs on the brain, modeling the forces and fluid flow over neighboring bone cells to understand bone development, and studying synchronization of brain rhythms in health and disease. The students will advance the analytical, logical, and numerical skills that are needed to continue their careers in STEM-related fields. The Site will prepare a diverse and well-prepared STEM workforce. The REU projects aim to address new and open problems in transplant immunology, fluid dynamics, and neuroscience. Students participating in the first REU project will work closely with a mathematician and immunologist to design, analyze, and validate a mathematical model of mouse heart transplantation in the presence of novel combination therapeutic approaches. The second project will involve a multiscale integrative model of bone cells and their surrounding interstitial fluid and bone matrix. This project will lead to a better understanding of bone development. In the third project, the students will develop a mathematical model (based on in vivo electrophysiological experimental data) that can be used to identify the neural mechanisms that underlie aberrant decision-making typical for alcoholic subjects. The fourth project will require mathematical modeling to understand the role of neural synchronization in brain functions. It will focus on understanding the increased interactions between the brain and heart during sleep.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项的全部或部分资金根据《2021 年美国救援计划法案》（公法 117-2）提供。印第安纳大学-普渡大学印第安纳波利斯分校 (IUPUI) 的 REU 项目将为来自美国各地的八名本科生提供进行应用于医学、流体动力学和神经科学的数学研究的机会。暑假期间，学生们将在印第安纳波利斯与 IUPUI 数学科学系的导师一起度过八周的时间。 REU 站点计划将向学生介绍跨学科研究经验，并产生将影响多个科学学科的新研究成果。具体来说，参与者将致力于四个主要项目之一：为心脏移植患者建立治疗策略模型，研究成瘾药物对大脑的影响，对邻近骨细胞上的力和液体流动进行建模以了解骨骼发育，以及研究骨骼发育的同步性。健康和疾病中的大脑节律。学生将提高在 STEM 相关领域继续职业生涯所需的分析、逻辑和数字技能。该站点将培养一支多元化且准备充分的 STEM 劳动力队伍。 REU 项目旨在解决移植免疫学、流体动力学和神经科学领域的新的和未解决的问题。参与第一个 REU 项目的学生将与数学家和免疫学家密切合作，设计、分析和验证存在新型联合治疗方法的小鼠心脏移植的数学模型。第二个项目将涉及骨细胞及其周围的间质液和骨基质的多尺度整合模型。该项目将有助于更好地了解骨骼发育。在第三个项目中，学生们将开发一个数学模型（基于体内电生理实验数据），可用于识别酗酒者典型的异常决策背后的神经机制。第四个项目将需要数学建模来理解神经同步在大脑功能中的作用。它将侧重于了解睡眠期间大脑和心脏之间增加的相互作用。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Heterogeneity of Ocular Hemodynamic Biomarkers among Open Angle Glaucoma Patients of African and European Descent

非洲和欧洲裔开角型青光眼患者眼部血流动力学生物标志物的异质性

• DOI: 10.3390/jcm12041287
• 发表时间: 2023-02
• 期刊: Journal of Clinical Medicine
• 影响因子: 3.9
• 作者: Siesky, Brent;Harris, Alon;Verticchio Vercellin, Alice;Arciero, Julia;Fry, Brendan;Eckert, George;Guidoboni, Giovanna;Oddone, Francesco;Antman, Gal
• 通讯作者: Antman, Gal

Metabolic blood flow regulation in a hybrid model of the human retinal microcirculation

人体视网膜微循环混合模型中的代谢血流调节

• DOI: 10.1016/j.mbs.2023.108969
• 发表时间: 2023-03
• 期刊: Mathematical Biosciences
• 影响因子: 4.3
• 作者: Albright, Amanda;Fry, Brendan C.;Verticchio, Alice;Siesky, Brent;Harris, Alon;Arciero, Julia
• 通讯作者: Arciero, Julia