Convergence: RAISE: Auto-regulatory Scaffolds for Directed Evolution of Non-living Functional Materials

融合：RAISE：非生命功能材料定向进化的自动调节支架

基本信息

批准号：
1848613
负责人：
Teri Odom
金额：
$ 100万
依托单位：
Northwestern University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-15 至 2022-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1848613&HistoricalAwards=false
关键词：
Convergence RAISE Auto regulatory Scaffolds

项目摘要

This award supports a new approach to identify and realize new functional materials under realistic conditions. The method is directed evolution of non-living materials based on auto-regulatory scaffold hosts. The method is bio-inspired. It mimics the approach observed in living things. The research involves developing a platform which incorporates synthesis, screening and feedback, by design, and offers a practical pathway to materials discovery. This strategy overcomes the limitations of screening materials via computer simulations only. The project builds on the convergence of different research areas such as tissue engineering, systems biology, scalable nanomanufacturing and machine learning. The discovery of new materials leads to new functionalities, which leads to new devices and systems, which leads to new products, which benefits society and economy and enhances the nation's prosperity and security. The project demonstrates a paradigm shift in materials discovery and invention. Education plans involve training graduate students and postdocs in convergence approaches to materials screening and discovery, design and realization of auto-regulatory scaffolds and machine learning. Outreach plans are to develop programs such as dissemination through public lectures, integration of research results into new undergraduate courses, and publication of perspectives that combine convergence of research from different fields.The project's approach is to screen materials through the auto-regulatory interaction of sensors, regulators and known and unknown materials. These components are located on scaffolds, which are tissue engineering-inspired constructs, whose dimensions are convenient for the developed fabrication and synthesis tools and which may be adapted to a wide range of node materials that include hydrogels, polymers, nanomaterials, and biomaterials. The auto-regulatory aspects of the research involve humidity and photothermal energy sources, among others. The auto-regulatory processes are based on interference effects, thermal expansion, chemical reactions, and cellular response and motion for which the project develops theory and modeling. One benefit of the evolutionary platform is that it interfaces seamlessly with seemingly incompatible combinations of materials such as hydrogels and semiconducting nanomaterials or biological cells and inorganic materials. Materials screening is coupled with machine learning methods for prediction of new materials, which can be extended to other user-defined outcomes.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项支持一种新的方法来识别和实现在现实条件下的新功能材料。该方法是基于自动调节脚手架宿主的非生存材料的定向演变。该方法受到生物启发。它模仿了在生物中观察到的方法。该研究涉及开发一个平台，该平台通过设计结合了综合，筛选和反馈，并提供了材料发现的实用途径。该策略仅通过计算机模拟克服了筛选材料的局限性。该项目建立在不同研究领域的融合基础上，例如组织工程，系统生物学，可扩展的纳米制造和机器学习。发现新材料会导致新的功能，从而导致新的设备和系统，从而导致新产品，从而使社会和经济受益，并增强国家的繁荣和安全。该项目证明了材料发现和发明的范式转变。教育计划涉及培训研究生和博士后，以融合材料筛查和发现，设计和实现自动调节性脚手架和机器学习的方法。推广计划是通过公开讲座，将研究结果整合到新的本科课程中以及发布观点的范围内开发计划，这些计划结合了不同领域的研究的融合。该项目的方法是通过传感器，监管机构和知名材料的自动调节性互动来筛选材料。这些组件位于脚手架上，它们是组织工程启发的构造，其尺寸对于开发的制造和合成工具很方便，并且可以适用于包括水凝胶，聚合物，纳米材料和仿生物质的各种节点材料。研究的自动调节方面涉及湿度和光热能源等。自动调节过程基于干扰效应，热膨胀，化学反应以及该项目开发理论和建模的细胞反应和运动。进化平台的一个好处是，它与看似不相容的材料（例如水凝胶和半导体纳米材料，生物细胞和无机材料）的材料无缝连接。材料筛选与用于预测新材料的机器学习方法相结合，可以扩展到其他用户定义的结果。该奖项反映了NSF的法定任务，并被认为是通过基金会的知识分子优点和更广泛的影响审查标准的评估来获得支持的。