Nanoscale Curvature Effects on the Properties of Anisotropic Nanomaterials

纳米曲率对各向异性纳米材料性能的影响

• 批准号: 1507790
• 负责人: Teri Odom
• 金额: $ 45万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2019-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1507790&HistoricalAwards=false
• 关键词: Nanoscale; Curvature; Effects; Properties; Anisotropic

With this award the Macromolecular, Supramolecular, and Nanochemistry (MSN) Program in the Chemistry Division is funding Professor Teri Odom at Northwestern University to study a specific type of nanoparticle -gold nanostars-that can be efficiently synthesized. Nanoparticles made from noble metals such as gold and silver are promising in a range of applications, from chemical sensors to optical imaging probes to anti-bacterial agents. However, preparing and controlling specific features (tips, edges, curves) on metal nanoparticles with non-spherical shapes are still challenging. These nanoscopic features are expected to be important as their sizes approach that of molecules. The project aims to obtain nanostars with desired features by tuning the chemistry at the nanoparticle surface. Broader impacts of these unique nanomaterials include integrating the one-pot gold nanostar synthesis with an existing lab on colloidal gold nanoparticles in freshmen general chemistry. In addition, freshman seminars focusing on nanoscience are developing projects similar to 'Ted Ed'-like videos explaining nano-concepts.This proposal seeks to determine how anisotropic nanomaterials that support unique curvature regions of positive, negative, and neutral curvature simultaneously exhibit properties distinct from symmetric (spherical) or elongated (rod-like) nanoparticles. Gold nanostars can serve as a unique model system since they can be synthesized through a seedless method resulting in distinct numbers of branches with tunable thicknesses and lengths. This work aims to resolve the mechanism of seedless growth at the single-particle level as well as determine how gold nanostar sample purity can be optimized by physical post-processing. Other goals include determining the structure-activity relationships of gold nanostars related to ligand attachment. Major outcomes of this work on nanoscale curvature include: (1) identifying functional groups in Good's buffers responsible for the formation gold nanostars with different branch numbers, branch lengths, and negative curvature degrees; (2) resolving the growth mechanism of gold nanostars at the single-particle level using in situ transmission electron microscopy; and (3) determining where biological ligands having secondary structure (double-stranded, looped, quadruplex) preferentially adsorb on the gold nanostars.

通过此奖项，化学部的大分子，超分子和纳米化学（MSN）计划是为西北大学的Teri Odom提供资金，用于研究一种特定类型的纳米粒子 - 纳米级 - 可以有效合成。 从化学传感器到光学成像探针再到抗细菌剂，由黄金和银等高贵金属制成的纳米颗粒有望。但是，在具有非球形形状的金属纳米颗粒上准备和控制特定特征（尖端，边缘，曲线）仍然具有挑战性。由于它们的大小接近分子的大小，因此这些纳米镜特征有望很重要。 该项目旨在通过调整纳米颗粒表面的化学性质来获取具有所需特征的纳米级。这些独特的纳米材料的更广泛的影响包括将一锅金纳米级合成与新生通用化学中的胶体金纳米颗粒上的现有实验室相结合。此外，专注于纳米科学的新生研讨会正在开发类似于“ TED ED”类似的纳米概念视频的项目。该建议旨在确定如何支持各向异性的纳米材料，这些纳米材料支持独特的曲率曲率的曲率，负面，负面和中性曲率同时表现出与中性曲率不同的属性或元素（spherical seperice ned（Spher）（spher）（spher）（spher）（spher）（spher）。金纳米船员可以用作独特的模型系统，因为它们可以通过无种子的方法合成，从而产生不同数量的具有可调厚度和长度的分支。这项工作旨在解决单粒子水平上无种子生长的机制，并确定如何通过物理后处理如何优化金纳米级样品纯度。其他目标包括确定与配体依恋相关的金纳米计的结构活性关系。这项关于纳米级曲率的工作的主要结果包括：（1）识别良好的缓冲液中的官能团，负责组成具有不同分支数，分支长度和负曲率度的形成金纳米级； （2）使用原位透射电子显微镜在单粒子水平上解决金纳米级体的生长机理； （3）确定具有二次结构（双链，循环，四链体）的生物配体优先吸附在金纳米级体上。