MRI: Acquisition of a Zeiss 880 Multiphoton and AiryScan Microscope System as a Shared Instrument for the Washington University Research Community

MRI：购买 Zeiss 880 多光子和 AiryScan 显微镜系统作为华盛顿大学研究界的共享仪器

• 批准号: 1828481
• 负责人: Ram Dixit
• 金额: $ 64.99万
• 依托单位: Washington University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-10-01 至 2021-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1828481&HistoricalAwards=false
• 关键词: MRI; Acquisition; Zeiss; 880; Multiphoton

An award is made to support the acquisition of a multiphoton confocal microscope to address the research needs of a large, diverse group of researchers in multiple departments at Washington University and in the St. Louis area. The new system will be housed in the Biology Department Imaging Core and will be readily accessible to university and regional users. The new imaging capabilities of this instrument will enable cutting edge multidisciplinary research and promote a well-prepared, diverse STEM workforce including students in underrepresented groups. The microscope will enhance the hands-on training of undergraduates through existing courses, in addition to the many Independent Study undergraduates that already use the Core. Furthermore, the instrument will enable the development of new teaching modules for other undergraduate biology classes where the need to procure data for many students in a short time frame precludes the use of existing instruments. This instrument will also have a large impact on underrepresented students involved in the Science Career Explorations programs, YMCA campus Y program for inner-city school children, and ENDURE program for underrepresented students entering neuroscience graduate school.The field of live cell imaging has recently enabled researchers to resolve physiological and molecular events in cells deep within tissues with micron- and millisecond-resolution. The new multiphoton system will provide deep, fast and super-resolution imaging technology for the first time to users in the departments of Biology, Physics, and Engineering at Washington University and from area institutions. Initial research uses for the new system will include work on cortical microtubules in plant cells; analysis of biosensors in root cells and pollen dynamics. Other researchers working with animal systems will study neuronal cell populations, tendon fascicles, and a range of other topics. Results from these studies will be published in peer-reviewed scientific journals, presented at scientific meetings, and used in both training and outreach activities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

颁发奖项是为了支持收购多光顿共聚焦显微镜，以满足华盛顿大学多个系和圣路易斯地区多元化研究人员的研究需求。新系统将安置在生物学部门成像核心中，并将容易被大学和区域用户访问。该工具的新成像功能将使尖端的多学科研究能够促进一个准备好的，多样化的STEM劳动力，其中包括代表性不足的群体中的学生。除了已经使用核心的许多独立研究的本科生外，显微镜还将通过现有课程来增强本科生的动手培训。此外，该工具将为其他本科生物学课程开发新的教学模块，在这些课程中，需要在短时间内为许多学生购买数据的需求排除了现有工具的使用。 This instrument will also have a large impact on underrepresented students involved in the Science Career Explorations programs, YMCA campus Y program for inner-city school children, and ENDURE program for underrepresented students entering neuroscience graduate school.The field of live cell imaging has recently enabled researchers to resolve physiological and molecular events in cells deep within tissues with micron- and millisecond-resolution.新的Multiphoton系统将首次为华盛顿大学和地区机构的生物学，物理和工程部门的用户提供深厚，快速和超分辨率的成像技术。新系统的最初研究用途将包括在植物细胞中的皮质微管上的工作。分析根细胞和花粉动力学中的生物传感器。 使用动物系统工作的其他研究人员将研究神经元细胞群，肌腱筋膜以及其他一系列主题。这些研究的结果将在经过同行评审的科学期刊上发表，在科学会议上提出，并在培训和外展活动中使用。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛的影响审查标准通过评估的支持。