Novel RF Volume Coils for High and Ultra-High Field Magnetic Resonance Imaging Scanners

用于高场和超高场磁共振成像扫描仪的新型射频体积线圈

基本信息

批准号：
1810492
负责人：
Branislav Notaros
金额：
$ 35万
依托单位：
Colorado State University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1810492&HistoricalAwards=false
关键词：
Novel RF Volume Coils Ultra

项目摘要

Magnetic resonance imaging (MRI) is an established medical diagnostic method and tool widely utilized to obtain high-resolution images of the internal structure of the body or its parts and organs, where atom nuclei of the tissue that is imaged absorb and reemit applied radio-frequency (RF) radiation. This is enabled by RF-excitation magnetic fields generated by so-called RF coils, whose frequency is proportional to the strength of the scanner's magnet, in units of tesla (T). Whereas state-of-the-art clinical MRI scanners are 3-T systems, MRI machines operating at 1.5 T still prevail in hospitals by a very large margin. MRI systems with stronger magnets and higher RF frequencies can provide higher resolution of images, faster exams, and more comfort for patients, among other improvements. However, they require new engineering and design approaches to make them operational, safe, and efficient. The main area of engineering research in advancing MRI scanners is in improving RF coils and fields. This exactly is the area of focus of this research project, aimed at introducing, developing, testing, evaluating, and establishing novel RF exciters and advancing RF coil designs for magnet strengths of 3 T, 4.7 T, 7 T, etc., for both state-of-the-art and next-generation clinical MRI scanners. The proposed research provides a new scientific methodology and engineering technology to solve a very general and challenging problem at the interface between RF and MRI and junction between engineering and science and with immediate applications, and hence it has substantial broader impacts on science and technology. Broader impacts on society are especially warranted by great and growing needs for medical diagnostic tools based on high-resolution imaging of human bodies, organs, and tissues. Education and outreach plan of this project includes enhancing course materials and delivery, advising and training of graduate students, undergraduate research, underrepresented groups, K-12 outreach, and international collaboration.High-field (HF) MRI scanners are referring to the main static magnetic field (generated by magnet) from 3 T to 7 T, while ultra-high field (UHF) is 7 T and above. The proposed approach and novel method for multi-channel excitation of RF magnetic fields is based on subject-loaded multifilar helical-antenna RF volume coils for HF and UHF MRI, to advance RF coil designs at both 3 T (current best, yet to be advanced and broadly adopted at clinics and hospitals) and 7 T (expected next major clinical overhaul in the near future, yet with lots of unknowns and challenges). The novelty of this approach consists of using the inner volume of the helix coil to excite the target sample. Preliminary MRI data obtained in phantoms at 7 T with 4- and 8-channel helix coils demonstrated the feasibility of the proposed approach, with consistency between experimental results and numerical simulations. Preliminary simulations at 3 T show that the helical-antenna exciter provides better RF-field uniformity and larger field of view than other reported results, with comparable transmit efficiencies. The project will pursue characterization, evaluation, and advancement of multi-channel helix RF coils at 3T and 7 T, respectively. Based on the obtained results, it will develop, optimize, and realize coils for 4.7 T operation, chosen for this proposed research midway between 3 T and 7 T, with RF efficiency, specific absorption rate distribution, and spatial RF-field encoding quantified in phantom experiments and in simulations. Principal goals are to provide improved RF performance while potentially preserving the easiness of use for a volume coverage coil, to determine the potential gains offered by the proposed new coil structures, and to further advance them closer to preclinical medical research and realization for clinical practice on a more global scale.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

磁共振成像（MRI）是一种已建立的医学诊断方法和工具，可广泛用于获取身体或其部分和器官内部结构的高分辨率图像，其中成像的组织原子核吸收并施加了reemit施加了无线电（RF）辐射。这是由所谓的RF线圈生成的RF激发磁场启用的，该磁场的频率与扫描仪磁体的强度成正比，以Tesla的单位（t）单位。最先进的临床MRI扫描仪是3-T系统，而在医院中运行的MRI机器在1.5 t的运行率仍然很大。具有较强磁铁和更高RF频率的MRI系统可以为患者提供更高的图像，更快的考试和更舒适的分辨率，以及其他改进。但是，它们需要新的工程和设计方法，以使它们具有运营，安全和高效。提高MRI扫描仪的工程研究的主要领域是改善RF线圈和田野。这是该研究项目的重点领域，旨在引入，开发，测试，评估和建立新型的RF兴奋剂，并推进RF线圈设计，以3 t，4.7 T，7 T，7 T等的磁铁优势，以实现最先进的和下一代的临床MRI扫描仪。拟议的研究提供了一种新的科学方法论和工程技术，可以在RF和MRI之间以及工程与科学之间的界面以及与立即应用之间的界面上解决一个非常普遍且具有挑战性的问题，因此，它对科学和技术产生了更大的广泛影响。基于人体，器官和组织的高分辨率成像的医学诊断工具需求，对社会的广泛影响尤其有必要。该项目的教育和外展计划包括增强课程材料和分娩，对研究生的建议和培训，本科研究，代表性不足的团体，K-12外展和国际合作。高级扫描仪（HF）MRI扫描仪指的是主要的静态磁场（由磁铁生成），而Ultra-High Field（Ullila-High Field（UHF）（UHF）（UHF）是7 t和Expect and Afterfield（UHF）。 RF磁场多通道激发的提议的方法和新方法基于HF和UHF MRI的受试者负载的多螺旋 - 静脉 - 静脉RF体积线圈，以在3 t上推进RF线圈设计（目前是最佳的，但在诊所和医院中却广泛地采用了近距离的临近临床，却是在挑战较大的临床范围内，并且在近距离临床上得到了挑战，并在近距离上进行了挑战。这种方法的新颖性包括使用螺旋线圈的内部体积来激发目标样品。用4通道和8通道螺旋线圈在7 t中在幻影中获得的初步MRI数据证明了该方法的可行性，并且在实验结果和数值模拟之间保持一致性。 3 t时的初步模拟表明，与其他报道的结果相比，螺旋形 - 安特纳兴奋剂提供了更好的RF场均匀性和更大的视野，具有可比的发射效率。该项目将分别在3t和7 t处进行多通道螺旋RF线圈的表征，评估和进步。基于获得的结果，它将开发，优化和实现4.7 t操作的线圈，并在3 t和7 t之间为此提出的研究选择，并具有RF效率，特定的吸收率分布和空间RF场在Phantom实验中量化了量化的空间RF场。主要目标是提供改进的RF性能，同时潜在地保留用于数量覆盖范围的使用的易用性，确定拟议的新线圈结构所提供的潜在收益，并进一步促进它们更接近临床前医学研究和实现临床医学实践的临床实践，以实现全球范围的临床实践，这反映了NSF的法定任务和综述，这是通过评估的依据，这是通过评估范围的，并且是通过Infeveliria的范围来构成的。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Surface Integral Computation for the Higher Order Surface Integral Equation Method of Moments

高阶曲面积分矩方程法的曲面积分计算

DOI：
发表时间：
2019
期刊：
ACES
影响因子：
0
作者：
Manić, S. B.;Notaros, B. M.
通讯作者：
Notaros, B. M.

RF Magnetic Field Profiling with a Dielectric Bore Lining for Traveling Waves in a 3-T MRI Scanner: A Computational Study

在 3-T MRI 扫描仪中使用电介质孔衬里进行行波射频磁场分析：计算研究

DOI：
发表时间：
2020
期刊：
Applied Computational Electromagnetics Society journal
影响因子：
0.7
作者：
Ilic, M. M.;Tonyushkin, A. A.;Athalye, P. S.;Sekeljic, N. J.;Kiruluta, A. J.;Notaros, B. M.
通讯作者：
Notaros, B. M.

Generalized Automatic Surface Reconstruction for CEM Simulations

CEM 模拟的广义自动表面重建