Unified Shim-RF Coil Technology for Improved Whole-Brain Spectroscopic MRI for Neurological Disorders

统一垫片射频线圈技术可改善神经系统疾病的全脑光谱 MRI

• 批准号: 10374136
• 负责人: HUI HAN
• 金额: $ 46.53万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10374136
• 关键词: 3-Dimensional; Address; Affect; Amygdaloid structure; Anatomy; Body part; Brain; Brain Hypoxia-Ischemia; Brain Neoplasms; Brain Stem; Brain region; Cerebellum; Childhood; Clinical; Collaborations; Communities; Contrast Media; Demyelinating Diseases; Diffusion Magnetic Resonance Imaging; Disease; Effectiveness; Epilepsy; Evaluation; Freedom; Frontal gyrus; Functional Magnetic Resonance Imaging; Gadolinium; Generations; Head; Hippocampus (Brain); Human; Image; Image Enhancement; Imaging Techniques; Imaging technology; Inferior; Inherited; Laws; Lesion; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Magnetism; Measures; Medial; Metabolic; Metabolic Diseases; Methods; Neonatal; Neurodegenerative Disorders; Organ; Patients; Pattern; Performance; Persons; Positioning Attribute; RF coil; Radiation therapy; Reporting; Reproducibility; Research Personnel; Resolution; Role; Sampling; Shapes; Signal Transduction; Site; Slice; Stroke; Structure; Techniques; Technology; Temporal Lobe; Time; Traumatic Brain Injury; Variant; Vendor; base; brain volume; contrast enhanced; design; disability; frontal lobe; imaging modality; improved; innovation; millimeter; minimal risk; multidisciplinary; nervous system disorder; novel; operation; prototype; quantitative imaging; spectroscopic imaging; standard of care; tool; treatment planning

Project Summary/Abstract Neurologic diseases affect as many as one billion people worldwide and are a major cause of disability and human suffering. Current standard of care imaging (contrast-enhanced MRI) is extremely limited to detect many neurological and neurodegenerative diseases. MR spectroscopic imaging (MRSI) has a great potential to supplement routine clinical MRI for clinical conditions including brain neoplasms, neonatal and pediatric disorders (hypoxia-ischemia, inherited metabolic diseases, and traumatic brain injury), demyelinating diseases, and infectious brain lesions. Gadolinium contrast agents have incomplete clearance, and repeated use of contrast-enhanced imaging has recently received an FDA warning due to brain accumulation. MRSI does not use contrast material and has no/minimal risk for patients. 3D encoded MRSI methods provide high sensitivity per unit time and unit volume. Presurgical and radiation treatment planning will greatly benefit from full 3D information, ideally with isotropic resolution. Echo-planar spectroscopic imaging (EPSI) based 3D whole-brain MRSI have been on most scanner platforms, and are probably the most commonly used fast MRSI techniques to date. The primary limitation of 3D MRSI has been magnetic B0 field inhomogeneity, which broadens lineshapes and diminishes spectral quality in about 40% of the brain (e.g., mesial temporal lobe, inferior frontal cortex, medial frontal gyrus, brainstem, and cerebellum). This limits the ability to evaluate critical brain regions such as mesial temporal lobe (MTL) and orbitofrontal cortex (OFC), which have pivotal roles across neurologic disorders. Recently, we introduced a radically novel concept called Unified Coil (UNIC), which includes innovative decoupling methods to bring the distance between separate shim and RF loops to zero millimeters. Both RF and shim coils are at a close proximity to the target organ for maximized RF SNR and shimming. Physical law implies that the only effective way to shim local inhomogeneous field (as in MTL/OFC) is by placing size-matched shim coils which generate opposite high-order field to counteract the inhomogeneous field. Our hypothesis is that UNIC will dramatically increase brain volume coverage and allow true metabolic evaluation of the entire brain using 3D MRSI. This will enable broader applications in patient management with various neurological disorders. The proposed study will prototype the first UNIC head coil (Aim 1), optimize the technique in shimming performance and hardware complexity (Aim 2), and assess the technique quantitatively in improving brain coverage of 3D MRSI (Aim 3). Successful completion of this study will largely resolve the longstanding B0 inhomogeneity issue in whole brain. Such coils can be widely used to benefit the entire MRSI community by advancing B0 shimming technology. It will help catalyze the widespread clinical acceptance of MRSI.

项目概要/摘要 神经系统疾病影响着全世界多达十亿人，是导致残疾和残疾的主要原因 人类的苦难。目前的护理成像标准（对比增强 MRI）对于检测许多疾病极为有限。 神经系统和神经退行性疾病。磁共振波谱成像（MRSI）具有巨大的潜力 补充常规临床 MRI，用于临床病症，包括脑肿瘤、新生儿和儿科 疾病（缺氧缺血、遗传性代谢疾病和创伤性脑损伤）、脱髓鞘疾病、 和感染性脑损伤。钆造影剂清除不完全，重复使用 对比增强成像最近因脑积聚而收到 FDA 警告。 MRSI 不 使用造影剂，对患者没有/最小的风险。 3D 编码 MRSI 方法提供高灵敏度 每单位时间和单位体积。术前和放射治疗计划将大大受益于全 3D 信息，最好具有各向同性分辨率。基于回波平面光谱成像 (EPSI) 的 3D 全脑 MRSI 已出现在大多数扫描仪平台上，并且可能是最常用的快速 MRSI 技术 迄今为止。 3D MRSI 的主要限制是 B0 磁场不均匀性，这会拓宽线形 并降低大脑约 40% 的光谱质量（例如内侧颞叶、下额皮质、 额内侧回、脑干和小脑）。这限制了评估关键大脑区域的能力，例如 内侧颞叶（MTL）和眶额皮质（OFC）在神经系统疾病中发挥着关键作用。 最近，我们引入了一个全新的概念，称为统一线圈 (UNIC)，其中包括创新的 使单独的垫片和射频环路之间的距离达到零毫米的去耦方法。射频和 匀场线圈非常靠近目标器官，以最大限度地提高射频信噪比和匀场效果。物理定律意味着 匀场局部不均匀场（如 MTL/OFC）的唯一有效方法是放置尺寸匹配的匀场 线圈产生相反的高阶场以抵消不均匀场。我们的假设是 UNIC 将显着增加大脑体积覆盖范围，并允许对整个大脑进行真正的代谢评估 使用 3D MRSI。这将使各种神经系统疾病的患者管理得到更广泛的应用。 拟议的研究将制作第一个 UNIC 头部线圈原型（目标 1），优化匀场技术 性能和硬件复杂性（目标 2），并定量评估改善大脑的技术 3D MRSI 的覆盖范围（目标 3）。这项研究的成功完成将在很大程度上解决长期存在的B0问题 全脑的不均匀性问题。这种线圈可以广泛使用，使整个 MRSI 社区受益 先进的B0匀场技术。它将有助于促进 MRSI 的广泛临床接受。