Unified Shim-RF Coil Technology for Improved Whole-Brain Spectroscopic MRI for Neurological Disorders

统一垫片射频线圈技术可改善神经系统疾病的全脑光谱 MRI

• 批准号: 10183019
• 负责人: HUI HAN
• 金额: $ 47.93万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10183019
• 关键词: 3-Dimensional; Address; Affect; Amygdaloid structure; Anatomy; Body part; Brain; Brain Hypoxia-Ischemia; Brain Neoplasms; Brain Stem; Brain region; Cerebellum; Childhood; Clinical; Collaborations; Communities; Contrast Media; Demyelinating Diseases; Diffusion Magnetic Resonance Imaging; Disease; Effectiveness; Epilepsy; Evaluation; Freedom; Frontal gyrus; Functional Magnetic Resonance Imaging; Gadolinium; Generations; Head; Hippocampus (Brain); Human; Image; Image Enhancement; Imaging Techniques; Imaging technology; Inferior; Inherited; Laws; Lesion; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Magnetism; Measures; Medial; Metabolic; Metabolic Diseases; Methods; Neonatal; Neurodegenerative Disorders; Organ; Patients; Pattern; Performance; Positioning Attribute; RF coil; Radiation therapy; Reporting; Reproducibility; Research Personnel; Resolution; Role; Sampling; Shapes; Signal Transduction; Site; Slice; Stroke; Structure; Techniques; Technology; Temporal Lobe; Time; Traumatic Brain Injury; Variant; Vendor; base; brain volume; contrast enhanced; design; disability; frontal lobe; imaging modality; improved; innovation; millimeter; minimal risk; multidisciplinary; nervous system disorder; novel; operation; prototype; quantitative imaging; spectroscopic imaging; standard of care; tool; treatment planning

Project Summary/Abstract Neurologic diseases affect as many as one billion people worldwide and are a major cause of disability and human suffering. Current standard of care imaging (contrast-enhanced MRI) is extremely limited to detect many neurological and neurodegenerative diseases. MR spectroscopic imaging (MRSI) has a great potential to supplement routine clinical MRI for clinical conditions including brain neoplasms, neonatal and pediatric disorders (hypoxia-ischemia, inherited metabolic diseases, and traumatic brain injury), demyelinating diseases, and infectious brain lesions. Gadolinium contrast agents have incomplete clearance, and repeated use of contrast-enhanced imaging has recently received an FDA warning due to brain accumulation. MRSI does not use contrast material and has no/minimal risk for patients. 3D encoded MRSI methods provide high sensitivity per unit time and unit volume. Presurgical and radiation treatment planning will greatly benefit from full 3D information, ideally with isotropic resolution. Echo-planar spectroscopic imaging (EPSI) based 3D whole-brain MRSI have been on most scanner platforms, and are probably the most commonly used fast MRSI techniques to date. The primary limitation of 3D MRSI has been magnetic B0 field inhomogeneity, which broadens lineshapes and diminishes spectral quality in about 40% of the brain (e.g., mesial temporal lobe, inferior frontal cortex, medial frontal gyrus, brainstem, and cerebellum). This limits the ability to evaluate critical brain regions such as mesial temporal lobe (MTL) and orbitofrontal cortex (OFC), which have pivotal roles across neurologic disorders. Recently, we introduced a radically novel concept called Unified Coil (UNIC), which includes innovative decoupling methods to bring the distance between separate shim and RF loops to zero millimeters. Both RF and shim coils are at a close proximity to the target organ for maximized RF SNR and shimming. Physical law implies that the only effective way to shim local inhomogeneous field (as in MTL/OFC) is by placing size-matched shim coils which generate opposite high-order field to counteract the inhomogeneous field. Our hypothesis is that UNIC will dramatically increase brain volume coverage and allow true metabolic evaluation of the entire brain using 3D MRSI. This will enable broader applications in patient management with various neurological disorders. The proposed study will prototype the first UNIC head coil (Aim 1), optimize the technique in shimming performance and hardware complexity (Aim 2), and assess the technique quantitatively in improving brain coverage of 3D MRSI (Aim 3). Successful completion of this study will largely resolve the longstanding B0 inhomogeneity issue in whole brain. Such coils can be widely used to benefit the entire MRSI community by advancing B0 shimming technology. It will help catalyze the widespread clinical acceptance of MRSI.

项目摘要/摘要 神经系统疾病在全球范围内影响多达十亿人，是残疾的主要原因 人类的痛苦。当前的护理标准成像（对比增强的MRI）非常有限以检测许多 神经和神经退行性疾病。 MR光谱成像（MRSI）具有很大的潜力 补充临床状况的常规临床MRI，包括脑肿瘤，新生儿和小儿 疾病（缺氧 - 异常，遗传的代谢疾病和创伤性脑损伤），脱髓鞘疾病， 和感染性脑部病变。 Gadolinium对比剂的间隙不完整，并且反复使用 由于大脑的积累，对比增强成像最近收到了FDA警告。 MRSI没有 使用对比材料，没有患者的风险最小。 3D编码的MRSI方法提供了高灵敏度 每单位时间和单位音量。术前和辐射治疗计划将大大受益于完整的3D 信息，理想情况下，以及各向同性分辨率。基于回声平面光谱成像（EPSI）的3D全脑 MRSI一直在大多数扫描仪平台上，可能是最常用的快速MRSI技术 迄今为止。 3D MRSI的主要局限性是磁性B0场不均匀性，它扩大了线形 并降低大脑约40％的光谱质量（例如，中颞叶，下额皮层， 内侧额叶，脑干和小脑）。这限制了评估关键大脑区域（例如 介体颞叶（MTL）和眶额皮质（OFC），它们在神经系统疾病中具有关键作用。 最近，我们介绍了一个名为Unified Coil（UNIC）的根本新颖概念，其中包括创新 将单独的垫片和RF环之间的距离带到零毫米之间的距离。 RF和 垫片线圈与目标器官的最大化射频SNR和刺激物紧密相邻。物理法暗示 唯一的有效方法是局部不均匀领域（如MTL/OFC中）是放置尺寸匹配的垫片 线圈产生相反的高阶场以抵消不均匀场的线圈。我们的假设是 UNIC将大大增加大脑体积覆盖范围，并允许对整个大脑进行真正的代谢评估 使用3D MRSI。这将在患有各种神经系统疾病的患者管理中更广泛的应用。 拟议的研究将原型制作第一个UNIC头线圈（AIM 1），优化了光滑技术 性能和硬件复杂性（AIM 2），并定量评估改善大脑的技术 3D MRSI的覆盖范围（AIM 3）。这项研究的成功完成将在很大程度上解决长期存在的B0 整个大脑中的不均匀性问题。这样的线圈可广泛用于使整个MRSI社区受益 推进B0光滑技术。它将有助于催化MRSI的广泛临床接受。