From Molecular Simplicity to Supramolecular Complexity: Low Symmetry Packings of Ionic Spherical Micelles

从分子简单性到超分子复杂性：离子球形胶束的低对称性堆积

基本信息

批准号：
1807330
负责人：
Mahesh Mahanthappa
金额：
$ 49.13万
依托单位：
University of Minnesota-Twin Cities
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-15 至 2022-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1807330&HistoricalAwards=false
关键词：
Molecular Simplicity Supramolecular Complexity Low

项目摘要

Surfactants are small molecules in which a water-soluble headgroup is attached to an insoluble tail. Common examples of useful surfactants are soaps and detergents. As a result of the different solubilities of the headgroup and the tail, surfactants spontaneously form ordered assemblies in water. The assemblies can range from very simple spheres dispersed in water to much more sophisticated geometries. However, predicting the geometry of a complex assembly from the chemical structure of the surfactant remains a significant challenge. Motivated by the desire to control surfactant assembly and access complex structures with unusual and useful properties, Prof. Mahesh Mahanthappa and his research team at the University of Minnesota-Twin Cities seek to understand how surfactant structure dictates the packing geometry and the stability of an assembly. Their discoveries could have broad implications for the future design and development of surfactants for applications such as enhanced oil recovery, personal care product formulation, drug encapsulation, and therapeutic delivery. The project also contributes to the interdisciplinary research training of undergraduate and graduate students, including members of underrepresented groups. Public outreach demonstrations using visually appealing soap bubble froths showcase the properties of surfactants and help to arouse the interest of students in science.A delicate balance of non-covalent interactions drives the supramolecular assembly of minimally hydrated amphiphiles into different lyotrophic liquid-crystalline phases. Of particular interest is the complex Frank-Kasper (FK) phases, which apparently arise from a frustrated non-covalent force balance that minimizes local variations in amphiphile solvation, while maximizing global micelle cohesion across the supramolecular assembly. Specific experiments of this project aim to 1) understand how the ionic amphiphile tail structure, counterion symmetry, and chirality impact micellar aggregation and consequent packing of the micelles into high coordination number, low symmetry lattices; 2) evaluate whether these complex packings are long-lived metastable states or thermodynamic equilibrium phases; and 3) assess whether non-ionic amphiphiles might form these complex phases. An important goal is to uncover new molecular design criteria that drive the formation of lyotropic liquid crystals with exceptional translational order, at length scales far exceeding those of their constituent molecular and supramolecular micelle building blocks.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

表面活性剂是小分子，其中水溶性头组附着在不溶性的尾巴上。有用表面活性剂的常见例子是肥皂和洗涤剂。由于头组和尾部的不同溶解度，表面活性剂自发地形成了水中的组件。组件的范围从分散在水中的非常简单的球到更复杂的几何形状。但是，从表面活性剂的化学结构中预测复杂组装的几何形状仍然是一个重大挑战。 Mahesh Mahanthappa教授及其在明尼苏达州 - 汤威大学（University of Minnesota-Twin）城市的研究团队渴望控制表面活性剂组装和访问复杂的结构的愿望，旨在了解表面活性剂结构如何决定包装几何形状和组件的稳定性。他们的发现可能对未来的设计和开发表面活性剂的设计具有广泛的影响，例如增强石油回收，个人护理产品配方，药物封装和治疗性提供。该项目还为本科生和研究生的跨学科研究培训做出了贡献，其中包括代表性不足的群体的成员。使用视觉上吸引人的肥皂泡泡沫展示了表面活性剂的特性，并有助于使学生对科学的兴趣展示。非共价互动的微妙平衡将微量水合的两亲性型超乳突驱动到不同的溶性液态液态液体阶段。特别令人感兴趣的是复杂的Frank-Kasper（FK）阶段，显然是由沮丧的非共价平衡引起的，它可以最大程度地减少两亲溶剂的局部变化，同时最大程度地提高了整个超分子组件的全球胶束凝聚力。该项目的特定实验旨在1）了解离子两亲尾结构，反式对称性和手性如何影响胶束聚集，然后将胶束堆积成高配位数，低对称晶格； 2）评估这些复杂的包装是长期寿命的亚稳态状态还是热力学平衡阶段； 3）评估非离子两亲物是否可能形成这些复杂阶段。一个重要的目标是发现新的分子设计标准，该标准推动了具有特殊翻译顺序的溶裂性液体晶体的形成，远远超出了其组成分子和超分子胶束的基础的尺寸。这项奖项反映了NSF的法定任务，并通过评估了基金会的智力效果，并通过评估了Crcria fightial and Interviatial and Broadia and tobleit and Interial and broughia and tobleit和Broadia and broughia and intirial and broaditial and broaditial and and tobrit。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Tuning Diblock Copolymer Particle Packing Symmetry with Variable Molecular Weight Core-Homopolymers

DOI：
10.1021/acs.macromol.2c01267
发表时间：
2022-09
期刊：
Macromolecules
影响因子：
5.5
作者：
A. J. Mueller;A. Lindsay;Ashish Jayaraman;S. Weigand;T. Lodge;M. Mahanthappa;F. Bates
通讯作者：
A. J. Mueller;A. Lindsay;Ashish Jayaraman;S. Weigand;T. Lodge;M. Mahanthappa;F. Bates

Dodecagonal quasicrystals of oil-swollen ionic surfactant micelles

DOI：
10.1073/pnas.2101598118
发表时间：
2021-08-03
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子：
11.1
作者：
Jayaraman, Ashish;Baez-Cotto, Carlos M.;Mahanthappa, Mahesh K.
通讯作者：
Mahanthappa, Mahesh K.

Protonation-Driven Aqueous Lyotropic Self-Assembly of Synthetic Six-Tail Lipidoids