Phylogenomics to advance understanding of world mosquito diversity and vector ecology

系统基因组学促进对世界蚊子多样性和媒介生态学的了解

• 批准号: 1754376
• 负责人: Brian Wiegmann
• 金额: $ 119.21万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1754376&HistoricalAwards=false
• 关键词: Phylogenomics; advance; understanding; world; mosquito

This project expands knowledge of genetic interrelationships and biological diversity in world mosquitoes. Comparison of genes and genomes allows greater insight into the basic biology of mosquitoes, their capacity to carry or resist disease transmission, and their response to environmental factors that affect their impact on human and animal populations in domestic and natural conditions. The project expands genomic sampling for mosquitoes broadly throughout the group, with special focus on diverse, but as yet unstudied, species sampled worldwide. The project will further the development of interactive data systems that provide species identification, a comparative framework for species comparison and identification, and an interactive data archive and retrieval system for information on mosquito genes, biology, pathogens, and geographic distributions. The project will train numerous graduate and undergraduate students in US institutions and connect with K-12 teachers and students through museum exhibits, professional development workshops, and classroom kits. Additionally, the project will engage the public in the process of doing science through citizen science efforts. Genomic sampling will be carried out from mosquito specimens held in museum repositories and from field collected samples. Anchored enrichment processes will be used to generate genomic data to identify monophyletic lineages and establish relationships within and among all higher culicid taxa, from specific to family level. The project will use comprehensively sampled phylogenetic estimates for mosquito clades that contain taxa that have crossed ecological boundaries to address evolutionary questions about domestication, and accompanying habitat- and host-shifts that appear to drive the evolution of major disease vectors. Lastly, the project will further expand the development of an existing species and pathogen biodiversity database (VectorMap), to include a data-enabled, interactive phylogeny of World mosquitoes that provides a contextualized interface for evolutionary studies of mosquito ecology, evolution, species interactions and taxonomic identification.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目扩大了世界蚊子中遗传相互关系和生物多样性的知识。 基因和基因组的比较，可以更深入地了解蚊子的基本生物学，携带或抵抗疾病传播的能力以及对影响其对家庭和自然状况中人类和动物人群影响的环境因素的反应。 该项目在整个小组中广泛地扩展了蚊子的基因组采样，特别关注多样化但尚未研究的物种在全球范围内采样。 该项目将进一步开发提供物种识别，物种比较和识别的比较框架以及有关蚊子基因，生物学，病原体和地理分布信息的交互式数据存档和检索系统的交互数据系统的开发。该项目将培训美国机构的众多毕业生和本科生，并通过博物馆展览，专业发展研讨会和教室套件与K-12教师和学生建立联系。此外，该项目将通过公民科学努力参与公众进行科学的过程。 基因组采样将从博物馆存储库中的蚊子标本和现场收集的样品中进行。 锚定的富集过程将用于生成基因组数据，以识别单系谱系，并在所有较高的库里奇群中和在家庭中，从特定到家庭水平建立关系。该项目将对包含跨越生态界限的分类群的蚊子进化枝进行全面抽样的系统发育估计，以解决有关驯化的进化问题，以及随附的栖息地和宿主 - 移动，这些问题似乎驱动了主要疾病媒介的进化。最后，该项目将进一步扩大现有物种和病原体生物多样性数据库（VectorMap）的开发，包括世界蚊子的支持，互动的系统发育，为蚊子生态学的进化研究提供了情境化的界面，以进行蚊子生态学，进化，物种相互作用和分类奖，并反映了NSF的代表性，并以此为基础。优点和更广泛的影响审查标准。

项目成果

Field Evidence of Mosquito Population Regulation by a Gregarine Parasite

格雷加林寄生虫调节蚊子数量的现场证据

• DOI: 10.1093/jme/tjab009
• 发表时间: 2021
• 期刊: Journal of Medical Entomology
• 影响因子: 2.1
• 作者: Soghigian, John;Livdahl, Todd
• 通讯作者: Livdahl, Todd

Advancing mite phylogenomics: Designing ultraconserved elements for Acari phylogeny

推进螨系统发育学：设计螨系统发育的超保守元素

• DOI: 10.1111/1755-0998.12962
• 发表时间: 2019
• 期刊: Molecular Ecology Resources
• 影响因子: 7.7
• 作者: Van Dam, Matthew H.;Trautwein, Michelle;Spicer, Greg S.;Esposito, Lauren
• 通讯作者: Esposito, Lauren

Phylogenomics reveals accelerated late Cretaceous diversification of bee flies (Diptera: Bombyliidae)

• DOI: 10.1111/cla.12436
• 发表时间: 2020-11
• 期刊: Cladistics
• 影响因子: 3.6
• 作者: Xuankun Li;L. Teasdale;Keith M. Bayless;A. Ellis;B. Wiegmann;C. Lamas;C. Lambkin;N. Evenhuis;J. Nicholls;D. Hartley;Seunggwan Shin;Michelle Trautwein;A. Zwick;Bryan D. Lessard;D. Yeates

Comparative Skip-Oviposition Behavior Among Container Breeding Aedes spp. Mosquitoes (Diptera: Culicidae)

• DOI: 10.1093/jme/tjab084
• 发表时间: 2021-05-28
• 期刊: JOURNAL OF MEDICAL ENTOMOLOGY
• 影响因子: 2.1
• 作者: Reinbold-Wasson, Drew David;Reiskind, Michael Hay
• 通讯作者: Reiskind, Michael Hay

Estimations of Fine-Scale Species Distributions of Aedes aegypti and Aedes albopictus (Diptera: Culicidae) in Eastern Florida

• DOI: 10.1093/jme/tjaa216
• 发表时间: 2021-03-01
• 期刊: JOURNAL OF MEDICAL ENTOMOLOGY
• 影响因子: 2.1
• 作者: Hopperstad, Kristen A.;Sallam, Mohamed F.;Reiskind, Michael H.
• 通讯作者: Reiskind, Michael H.