Iron(III) Coordination Complexes as MRI Contrast Agents

铁 (III) 配位络合物作为 MRI 造影剂

基本信息

批准号：
1710224
负责人：
Janet Morrow
金额：
$ 48.94万
依托单位：
SUNY at Buffalo
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2017
资助国家：
美国
起止时间：
2017-06-01 至 2020-12-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1710224&HistoricalAwards=false
关键词：
Iron III Coordination Complexes MRI

项目摘要

In this project funded by the Chemical Structure, Dynamic & Mechanism B and the Chemical Measurement & Imaging Programs of the Chemistry Division, Professor Janet R. Morrow of the Department of Chemistry at the University at Buffalo, State University of New York is developing new classes of iron (Fe) complexes as magnetic resonance imaging (MRI) contrast agents. The goal of this research is to obtain new iron-based agents that produce effective MRI contrast at the field strengths found in the newest MRI scanners. Iron is a biologically relevant metal ion that may be an alternative to the currently used gadolinium, which has tolerance issues in imaging. The project lies at the interface of organic and inorganic chemistry, as well as physiology and imaging physics and is therefore well suited to the education of scientists at all levels. Professor Morrow has a strong record of educating a diverse group of graduate and undergraduate students. Outreach activities involving K-12 students and their science teacher are also be part of the funded project. Macrocyclic Fe(III) complexes are being developed as MRI contrast agents with the goal of obtaining agents that produce effective T1 contrast at the clinically relevant magnetic field of 3 Tesla (T). The complexes contain highly stabilized Fe(III) centers that do not produce reactive oxygen species. Complexes that contain one bound water or no water ligands are to be studied to assess the effect of outer versus innersphere water on T1 relaxivity. A second emphasis is to develop Fe(III) contrast agents that change paramagnetic properties with temperature and pH. These spin state changes interconvert Fe(III) paramagnetic CEST (Chemical Exchange Saturation Transfer) agents and T1 contrast agents. EPR (Electron paramagnetic resonance) and Mossbauer spectroscopy will be used for characterization of the complexes. To study the magnetic field strength dependence of relaxivity, the complexes will be studied on MRI scanners at 1.5 T, 3.0 T and 4.7 T. A nuclear magnetic resonance dispersion spectrum will be obtained for selected Fe(III) complexes. The most effective Fe(III) contrast agents will be studied and compared to Gd(III) contrast agents in biological samples.

在该项目由化学结构，动态与机制B以及化学部的化学测量与成像计划资助的项目中，纽约州立大学布法罗大学化学系的Janet R. Morrow教授正在开发新的铁（FE）配合物，作为磁共振成像（MRI）的损坏药物。这项研究的目的是获得新的基于铁的剂，这些试剂在最新的MRI扫描仪中发现的现场强度产生有效的MRI对比度。铁是一种与生物学相关的金属离子，可能是当前使用的gadolinium的替代品，它在成像中存在耐受性问题。该项目在于有机和无机化学的界面，以及生理学和成像物理学，因此非常适合各级科学家的教育。莫罗教授在教育各种各样的研究生和本科生方面有很强的记录。涉及K-12学生及其科学老师的外展活动也是资助项目的一部分。大环Fe（III）复合物作为MRI对比剂开发，其目的是获得在3 Tesla（T）的临床相关磁场上产生有效T1对比的剂。这些复合物包含高度稳定的Fe（III）中心，这些中心不产生活性氧。要研究包含一个结合水或不含水配体的复合物，以评估外部水对T1松弛性的影响。第二个强调是开发Fe（III）对比剂，以随温度和pH的速度改变顺磁性。这些自旋状态变化互连Fe（III）顺磁性CEST（化学交换饱和转移）和T1对比剂。 EPR（电子顺磁共振）和Mossbauer光谱将用于表征复合物。为了研究宽松度的磁场强度依赖性，将在1.5 T，3.0 T和4.7 T的MRI扫描仪上研究复合物。将获得针对选定的Fe（III）复合物的核磁共振分散光谱。将研究最有效的Fe（III）对比剂，并将其与生物样品中的GD（III）对比剂进行比较。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Saccharomyces cerevisiae and Candida albicans Yeast Cells Labeled with Fe(III) Complexes as MRI Probes

用 Fe(III) 复合物标记的酿酒酵母和白色念珠菌酵母细胞作为 MRI 探针

DOI：
10.3390/magnetochemistry6030041
发表时间：
2020
期刊：
Magnetochemistry
影响因子：
2.7
作者：
Patel, Akanksha;Asik, Didar;Snyder, Eric M.;Spernyak, Joseph A.;Cullen, Paul J.;Morrow, Janet R.
通讯作者：
Morrow, Janet R.

Inner-Sphere and Outer-Sphere Water Interactions in Co(II) paraCEST Agents