NSF/FDA SIR: Defining Print Fidelity and Performance of Bioactive 3D Printed Scaffolds.

NSF/FDA SIR：定义生物活性 3D 打印支架的打印保真度和性能。

• 批准号: 1641081
• 负责人: Abraham Joy
• 金额: $ 10万
• 依托单位: University of Akron
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1641081&HistoricalAwards=false
• 关键词: NSF; FDA; SIR; Defining; Print

Non-technical: Biomedical products obtained through 3D printing of degradable polymers is a promising method for the fabrication of synthetic scaffolds and implantable devices. Future biomedical implants will likely be designed specifically for each patient, personalizing the product to the specific needs of the patient. Personalized 3D printed biomedical products will be designed with patient specific geometric features. Such devices will also contain therapeutic dosages specific for each patient. However to get to the reliable production of such structures, there are several scientific challenges that need to be addressed and this award enables addressing some of these challenges. For example, when a therapeutic is encapsulated within a polymer that is 3D printed, the interactions between the therapeutic and the polymer affect the printability and the quality of the printed structure. Work carried out through this award will examine the type and amount of drugs that can be incorporated in polymers and the effects of drug incorporation on the print quality. Furthermore, the work will characterize the degradation of the 3D printed polymer scaffolds and the rate of therapeutic release from the 3D printed structures. Since such 3D printed scaffolds are proposed to be used in a biological context, the growth and behavior of cells on the 3D printed structures will be examined and any potential cytotoxicity will be evaluated. The work carried out through this award will advance the nascent field of custom designed 3D printed polymeric devices and will provide a body of knowledge for other scientists and engineers to advance the field. In addition, the award provides training for graduate and undergraduate students in an interdisciplinary and emergent STEM field.Technical: 3D printing is a potentially viable protocol for efficient manufacturing of customized biomedical devices. 3D printing medical devices addresses several desired implant features such as the need to print irregular feature shapes and sizes and the need for implant porosity and the ability to incorporate or encapsulate bioactive molecules. Increasingly, such 3D printed devices are encapsulated with bioactive small molecules, peptides or other biologically active agents. This award enables the study of dispersion of small molecule therapeutics within a recently developed solvent-free, low modulus polyester system that is suitable for 3D printing bio-scaffolds. The work will provide an understanding of the Flory-Huggins interaction parameters that affect the dispersion of small molecule therapeutics in the above described viscous polyester. The effect of such encapsulated bioactives on the print fidelity will be examined and the work will provide a foundation to predict the amount of bioactive that can be incorporated within such 3D printed scaffolds. An important part of the proposed work is to study the degradation behavior of such bioactive scaffolds and examine the release behavior of bioactives from the 3D printed scaffolds. Finally, the work will evaluate the cytotoxicity of the scaffolds and their degradation products.

非技术性：通过可降解聚合物 3D 打印获得的生物医学产品是制造合成支架和可植入装置的一种有前途的方法。未来的生物医学植入物可能会专门为每位患者设计，根据患者的具体需求个性化产品。个性化 3D 打印生物医学产品将根据患者特定的几何特征进行设计。此类装置还将包含针对每位患者的特定治疗剂量。然而，为了实现此类结构的可靠生产，需要解决一些科学挑战，而该奖项能够解决其中一些挑战。例如，当治疗剂被封装在 3D 打印的聚合物内时，治疗剂和聚合物之间的相互作用会影响打印结构的可打印性和质量。通过该奖项开展的工作将检查可掺入聚合物中的药物的类型和数量以及药物掺入对印刷质量的影响。此外，这项工作还将表征 3D 打印聚合物支架的降解以及 3D 打印结构的治疗释放速率。由于此类 3D 打印支架拟用于生物环境，因此将检查 3D 打印结构上细胞的生长和行为，并评估任何潜在的细胞毒性。通过该奖项开展的工作将推动定制设计 3D 打印聚合物设备这一新兴领域的发展，并为其他科学家和工程师推动该领域的发展提供大量知识。此外，该奖项还为研究生和本科生提供跨学科和新兴 STEM 领域的培训。技术：3D 打印是高效制造定制生物医学设备的潜在可行方案。 3D 打印医疗设备可满足多种所需的植入物特征，例如打印不规则特征形状和尺寸的需要、植入物孔隙度的需要以及掺入或封装生物活性分子的能力。此类 3D 打印设备越来越多地采用生物活性小分子、肽或其他生物活性剂进行封装。该奖项使得研究人员能够研究小分子治疗药物在最近开发的无溶剂、低模量聚酯系统中的分散情况，该系统适用于 3D 打印生物支架。这项工作将提供对影响小分子治疗药物在上述粘性聚酯中分散的弗洛里-哈金斯相互作用参数的理解。将检查此类封装的生物活性物质对打印保真度的影响，并且这项工作将为预测可纳入此类 3D 打印支架中的生物活性物质的量奠定基础。该工作的一个重要部分是研究此类生物活性支架的降解行为，并检查 3D 打印支架中生物活性物质的释放行为。最后，该工作将评估支架及其降解产物的细胞毒性。

项目成果

Opposing Effects of Side-Chain Flexibility and Hydrogen Bonding on the Thermal, Mechanical, and Rheological Properties of Supramolecularly Cross-Linked Polyesters

侧链柔性和氢键对超分子交联聚酯的热、机械和流变特性的相反影响

• DOI: 10.1021/acs.macromol.8b01781
• 发表时间: 2018-11-27
• 期刊: MACROMOLECULES
• 影响因子: 5.5
• 作者: Liu, Qianhui;Wang, Chao;Joy, Abraham
• 通讯作者: Joy, Abraham