I-Corps: Silicon Nanocrystals

I-Corps：硅纳米晶体

• 批准号: 1565469
• 负责人: Brian Korgel
• 金额: $ 5万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-10-15 至 2016-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1565469&HistoricalAwards=false
• 关键词: Corps; Silicon; Nanocrystals

Nanomaterials can be designed and created with both imaging and therapeutic function for medical applications. These materials are expected to be important for future personalized medicine. This I-Corps team will explore the use of a new nanomaterials platform of light-emitting silicon nanocrystals as bioimaging markers and therapeutic agents for medicine. Silicon nanocrystals offer unique properties that might be used in humans to provide valuable medical information without toxic side-effects. The I-Corps team will determine the clinical need and market fit for biocompatible silicon nanocrystals. This I-Corps team has developed biocompatible and non-toxic silicon nanocrystals that are bright emitters of near infrared light. The nanocrystals can be dispersed in water, tethered with molecular recognition molecules, or coated with surfactant for introduction into living systems with specifically engineered interactions with different cell types. The potential exists to use these materials for medical imaging and therapeutics. The silicon nanocrystals can be used to generate singlet oxygen or heat to trigger a therapeutic response or to act as a drug-release trigger. In this project, the I-Corps team intends to take the first step towards commercialization by identifying a possible formulation with a specific medical application with commercial potential by conducting market research.

纳米材料可以通过成像和治疗功能为医疗应用设计和创建。 预计这些材料对于将来的个性化医学很重要。 这个I-Corps团队将探索使用发光硅纳米晶体的新纳米材料平台作为医学的生物成像标记和治疗剂。 硅纳米晶体提供了独特的特性，这些特性可能在人类中用于提供宝贵的医疗信息而没有有毒副作用。 I-Corps团队将确定生物相容性硅纳米晶体的临床需求和市场拟合。 这个I-Corps团队已经开发了生物相容性和无毒的硅纳米晶体，它们是近红外光的明亮发射器。 纳米晶体可以分散在水中，用分子识别分子束缚，也可以用表面活性剂覆盖，以引入具有不同细胞类型的特定工程相互作用的生物系统。 可能存在将这些材料用于医学成像和治疗剂的潜力。 硅纳米晶体可用于产生单线氧或热量以触发治疗反应或充当药物释放触发因素。在该项目中，I-Corps团队打算通过通过进行市场研究来识别具有具有商业潜力的特定医疗应用的可能配方，迈出商业化的第一步。