CAREER:Bio-electro-photonic Microsystem Interfaces for Small Animals

职业：小动物生物光电微系统接口

• 批准号: 1554367
• 负责人: Alper Bozkurt
• 金额: $ 50万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-02-15 至 2022-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1554367&HistoricalAwards=false
• 关键词: CAREER; Bio; electro; photonic; Microsystem

Proposal Number: ECCS - 1554367 Proposal Title: CAREER: Bio-electro-photonic Microsystem Interfaces for Small AnimalsPI Name: Bozkurt, Alper Y. Institution: North Carolina State UniversityObjective:The investigator proposes a wirelessly powered injectable capsule capable of monitoring bio-potentials and bio-photonic physiological signals including heart rate, respiration rate, oxygen saturation, pulse transit time and core body temperature. The proposed investigation includes a complete system integration and extensive evaluation. Non-technical Abstract: The emerging field of Bionic MicroSystems offers new engineering opportunities to solve real life problems. By fusing biological organisms with synthetic electronic systems, a quantum leap can be enabled in our ever-lasting engineering struggle to mimic relatively more complicated properties of biological machines, such as autonomy, intelligence, and biocomplexity observed across various length scales. This project targets to overcome major technical barrier in the way of such achievement, which is the inefficiency of state-of-art interfaces that would provide real-time information about the state of the biological organism. The proposed microsystem will open a physiological window to improve understanding of the physiology of small animals in their natural environment. The unique interdisciplinary and hands-on nature of this project will help us to reach out to all citizens"women and men, underrepresented minorities, and persons with disabilities"and train them to use bioelectronics, biophotonics, and wearable wireless physiological systems. Further, we will design other modules including presentations, show and tell displays, and design contests. We will also use these to develop a new course and lab modules. We will engage with the public at large by means of our collaboration with local museums. In these activities, we will leverage our successful track record of media coverage by and continuing interaction with prominent national and international media agencies.Technical Abstract: Our long term goal is to enable microsystem based platforms that would perform various physiological measurements wirelessly in small animals. In doing so, we can respond to the critical need for a novel minimally invasive class of systems for continuous recording of key physiological parameters in natural environments without disturbing natural behavior. To address the challenge of higher power consumption of such systems, we will (a) benefit from the advantages of subcutaneous measurements and (b) design custom front-end circuits that would reduce power consumption through multiple strategies. To enable wireless assessment of multiple physiological parameters in ultra-miniaturized form factors, the microsystems will include state-of-the-art circuit approaches, wireless power and communication systems, and sealed packaging with extruding electrodes. The efficacy of the system will be assessed on a four platform testbed: (a) in silico using a computational model, (b) in vitro using a tissue phantom, (c) ex vivo using animal cadavers, and (d) in vivo using rat models.

提案编号：ECCS - 1554367 提案标题：职业：小动物生物电光子微系统接口 PI 姓名：Bozkurt, Alper Y. 机构：北卡罗来纳州立大学 目的：研究者提出一种无线供电的可注射胶囊，能够监测生物电势和生物光子生理信号，包括心率、呼吸频率、氧饱和度、脉搏传播时间和核心体温。拟议的调查包括完整的系统集成和广泛的评估。非技术摘要：仿生微系统的新兴领域为解决现实生活问题提供了新的工程机会。通过将生物有机体与合成电子系统融合，我们可以在我们永恒的工程努力中实现量子飞跃，以模仿生物机器相对更复杂的特性，例如在不同长度尺度上观察到的自主性、智能和生物复杂性。该项目的目标是克服实现这一目标的主要技术障碍，即提供有关生物有机体状态的实时信息的最先进接口的低效率。所提出的微系统将打开一个生理窗口，以增进对自然环境中小动物生理学的了解。该项目独特的跨学科和实践性质将帮助我们接触所有公民“女性和男性、代表性不足的少数民族和残疾人”，并培训他们使用生物电子学、生物光子学和可穿戴无线生理系统。此外，我们还将设计其他模块，包括演示、展示和讲述展示以及设计竞赛。我们还将使用它们来开发新的课程和实验室模块。我们将通过与当地博物馆的合作与广大公众互动。在这些活动中，我们将利用我们成功的媒体报道记录以及与著名的国家和国际媒体机构的持续互动。技术摘要：我们的长期目标是实现基于微系统的平台，能够在小动物中无线执行各种生理测量。通过这样做，我们可以满足对新型微创系统的迫切需求，该系统可以在不干扰自然行为的情况下连续记录自然环境中的关键生理参数。为了解决此类系统功耗较高的挑战，我们将（a）受益于皮下测量的优势，（b）设计定制前端电路，通过多种策略降低功耗。为了能够以超小型化的形式对多个生理参数进行无线评估，微系统将包括最先进的电路方法、无线电源和通信系统以及带有挤压电极的密封包装。该系统的功效将在四个平台测试台上进行评估：（a）使用计算模型进行计算机模拟，（b）使用组织模型进行体外测试，（c）使用动物尸体进行体外测试，以及（d）使用大鼠模型。