REU Site: Cellular Bioengineering -- From Biomaterials to Stem Cells

REU 网站：细胞生物工程——从生物材料到干细胞

• 批准号: 1559968
• 负责人: David Shreiber
• 金额: $ 41.25万
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-10-01 至 2021-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1559968&HistoricalAwards=false
• 关键词: REU; Site; Cellular; Bioengineering; Biomaterials

The REU Site: Cellular Bioengineering -- From Biomaterials to Stem Cells offers students exciting research projects that introduce them to a broad array of topics grounded in Cellular Bioengineering. Cellular Bioengineering encompasses a number of cutting edge research fields and articulates with nanotechnology, advanced materials, systems biology and stem cells. Training undergraduate students with diverse backgrounds in Cellular Bioengineering will broaden the research base and lead to an expanded and better-trained workforce in this rapidly expanding field. Program elements in innovation, entrepreneurship, and translational research enhance the students' marketable skill set and increase the potential for their current and future discoveries to be converted to technological advances of great impact. Unlike the traditional research that undergraduates typically conduct, the REU Site program is leveraging broad-based training through engineering projects that additionally integrate efforts across the life sciences and physical sciences. The recruitment efforts specifically target individuals who normally have limited research opportunities, including those from underrepresented groups and from colleges without substantial graduate research and training. The program expects to expand the pipeline of students entering graduate programs, by helping to engage a group who would likely have not considered graduate school. The REU Site is employing standardized elements of research training and professional development to accelerate the students' learning curve and inoculate them into active laboratories that are pursuing high-impact Cellular Bioengineering research. The program is employing active mentoring, collaboration, and regular monitoring of the students to achieve its goals. Project areas that the students will work on include: 1) Multi-modal cues for phenotypic control of neural cells, 2) Polymer nanoformulations for delivery of macromolecular therapeutics, 3) High Throughput, Automated, Single Cell Electroporation, 4) Encapsulated MSC Regulation of Inflammatory Environments, 5) Cell and tissue engineering approaches to tendon and ligament healing, 6) Reprogrammed Stem Cells and 3-D Microenvironments, 7) High Throughput Platform for Drug Metabolism Screening in Fatty Liver Cells, 8) Interactions of lipid-based nanocarriers with vascular endothelia and macrophages, 9) Designing Scaffold Cues for Retinal Pigment Epithelial Tissue Engineering, 10) Subcellular structural dynamics and mechanotransduction to branching neurons, and 11) Non-destructive measurement of tissue morphomechanical properties. A Cellular Bioengineering Boot Camp introduces participants to laboratory and imaging skills that accelerates their integration into their research labs. A focus on Innovation and Entrepreneurship parallels the recent NSF I-Corps initiative for translational research to capitalize on the potential for new technology that emanates from the research. A component of the program is a clinical immersion, where the REU scholars will observe clinicians in the surgical unit. The Scholars use these experiences to identify needs and problems and brainstorm about innovations and technologies to solve these problems. Under the guidance of faculty from the Center for Innovative Ventures of Emerging Technologies, the students build business plans around these ideas. Weekly seminars and discussion groups allow tracking and monitoring of the Scholars' experiences while concurrently engaging them in professional development. Incorporation of a mentoring workshop for the graduate students who serve as "near-peer" mentors further broadens the impact of the program.

REU站点：细胞生物工程 - 从生物材料到干细胞为学生提供令人兴奋的研究项目，这些研究项目将其引入基于细胞生物工程的广泛主题。细胞生物工程包括许多尖端研究领域，并使用纳米技术，高级材料，系统生物学和干细胞进行表达。培训具有蜂窝生物工程背景不同背景的本科生将扩大研究基础，并在这个迅速扩展的领域中提供扩大，训练有素的员工队伍。创新，创业和翻译研究的计划要素增强了学生的可销售技能，并提高了他们当前和未来发现的潜力，并将其转换为巨大影响的技术进步。与本科生通常进行的传统研究不同，REU网站计划通过工程项目利用基于广泛的培训，这些项目还整合了整个生命科学和物理科学的努力。招聘工作专门针对通常具有有限研究机会的个人，包括来自代表性不足的群体以及来自没有大量研究生研究和培训的大学。该计划预计，通过帮助参与一个可能没有考虑研究生院的小组来扩大进入研究生课程的学生的渠道。 REU网站正在采用标准化的研究培训和专业发展的要素，以加速学生的学习曲线，并将其接种成主动实验室，这些实验室正在追求高影响力的细胞生物工程研究。该计划正在利用积极的指导，协作和定期监控学生实现目标。学生将要研究的项目领域包括：1）多模式的神经细胞表型控制的多模式线索，2）聚合物纳米制造用于传递大分子分子治疗剂，3）3）高吞吐量，高吞吐量，自动化，单细胞电穿孔，4）炎症环境和炎症环境的封装3）3个细胞和组织式均可治愈，5）3个），6）微环境，7）在脂肪肝细胞中筛查药物代谢筛查的高通量平台，8）基于脂质的纳米载体与血管内皮和巨噬细胞的相互作用，9）设计视网膜色素的脚手架提示，用于视网膜色素的上皮组织上皮组织工程，10）下层结构性动力学和分支机构的分支机构，以及分支机构的分支机构，以及分支机构的机械性培养基，以及分支机构的机械性培养基，并）形态力学特性。蜂窝工程训练营向参与者介绍了实验室和成像技能，从而加速了他们与研究实验室的融合。对创新和企业家精神的重点与最近的NSF I-Corps倡议相似，该计划是转化研究，以利用从研究中散发出的新技术的潜力。该计划的一个组成部分是临床沉浸式，REU学者将在手术单位观察临床医生。学者利用这些经验来确定需求，问题以及有关创新和技术的头脑风暴，以解决这些问题。在新兴技术创新企业中心的教师指导下，学生围绕这些想法制定业务计划。每周的研讨会和讨论小组允许跟踪和监视学者的经历，同时让他们参与专业发展。为“近亲”指导者的研究生纳入指导研讨会，进一步扩大了该计划的影响。