CAREER: Engineered biomaterial gradients for control of neural cells

职业：用于控制神经细胞的工程生物材料梯度

• 批准号: 0846328
• 负责人: David Shreiber
• 金额: $ 40万
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0846328&HistoricalAwards=false
• 关键词: CAREER; Engineered; biomaterial; gradients; control

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).0846328ShreiberIntellectual Merit: The proposed microfluidics system uniquely allows examination of a combinations of factors in a physiologically relevant 3D environment, and holds great promise for elucidating guidance principles that underlay neurodevelopment and for identifying and implementing regenerative therapies, particularly in conjunction with the quantitative modeling of growth cone and filopodial (thin cytoplasmic protusions from the cell) dynamics.Broader Impact: Thousands of patients suffer from central nervous system (CNS) trauma and degenerative disorders and may ultimately benefit from this research. Two hundred economically disadvantaged students are recruited into the Future Scholars program each year - or 1,000 students over the course of this proposal, and Rutgers' home communities are largely dominated demographically by under-represented groups. The proposed initiatives provide unique opportunities to these students that will excite them about education and training in biomedical and tissue engineering and helps shape future leaders of our scientific and engineering communities.

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).0846328ShreiberIntellectual Merit: The proposed microfluidics system uniquely allows examination of a combinations of factors in a physiologically relevant 3D environment, and holds great promise for elucidating guidance principles that underlay neurodevelopment and for identifying and implementing regenerative therapies, particularly in与生长锥和丝虫（细胞质薄细胞质产生）动力学的定量建模。BRODER的影响：成千上万的患者患有中枢神经系统（CNS）创伤和退化性疾病，最终可能受益于这项研究。每年有200名在经济上处于弱势群体的学生被招募到未来的学者计划中 - 或在本提案过程中1,000名学生，而罗格斯的家庭社区在很大程度上受到代表性不足的群体的控制。拟议的举措为这些学生提供了独特的机会，这将使他们对生物医学和组织工程领域的教育和培训感到兴奋，并有助于塑造我们科学和工程社区的未来领导者。