MRI: Acquisition of a 600 MHz NMR Spectrometer for Chemistry

MRI：购买用于化学的 600 MHz NMR 波谱仪

• 批准号: 1531620
• 负责人: Frank McDonald
• 金额: $ 62.99万
• 依托单位: Emory University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1531620&HistoricalAwards=false
• 关键词: MRI; Acquisition; 600; MHz; NMR

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation (CRIF) and Chemistry of Life Processes (CLP) programs, Emory University will acquire a 600 MHz NMR spectrometer. This instrumentation will advance research activities spanning the fields of synthetic organic chemistry, catalysis and new methodology development, natural products and materials characterization, inorganic chemistry, biomolecular chemistry, and the integration of spectroscopic information with theoretical studies. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out modern research. This instrument will also be an integral component in training undergraduate and graduate students. It will advance the teaching and research training mission of the department by providing hands-on NMR experience in applying advanced NMR topics covered in core academic and supplemental summer courses.The award is aimed at enhancing research in areas such as (a) studying natural product synthesis; (b) studying reactivity, catalysis and synthetic strategy, to drive pharmaceutical and materials innovation; (c) developing stereoselective methods and their applications in total synthesis and drug discovery; (d) discovering reactions with a particular aim to apply to transition metal chemistry; (e) understanding signaling pathways involved in human health and disease; (f) exploring functional and well-defined macromolecular structures with various applications; (g) studying polyoxometalate (POM) complexes and POM-based materials, and their uses as catalysts; (h) developing synthetic methods in contexts ranging from selective activation and functionalization of traditionally inert starting materials; (i) developing small molecular radiotracers for positron emission tomography; (i) studying antimicrobial principles in medicinal plants; and (j) discovering therapeutic agents and the structural basis for their interactions with target proteins.

凭借主要研究仪器计划 (MRI) 的奖励以及化学研究仪器 (CRIF) 和生命过程化学 (CLP) 计划的支持，埃默里大学将购买一台 600 MHz NMR 波谱仪。该仪器将推进合成有机化学、催化和新方法开发、天然产物和材料表征、无机化学、生物分子化学以及光谱信息与理论研究的整合等领域的研究活动。一般来说，核磁共振 (NMR) 光谱是化学家阐明分子结构的最强大工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于进行现代研究的化学家来说，使用最先进的核磁共振波谱仪至关重要。该仪器也将成为培养本科生和研究生的一个组成部分。它将通过提供应用核心学术和补充夏季课程中涵盖的高级 NMR 主题的实际 NMR 经验来推进该部门的教学和研究培训任务。该奖项旨在加强以下领域的研究：(a) 研究天然产物合成; (b) 研究反应性、催化和合成策略，以推动制药和材料创新； (c) 开发立体选择性方法及其在全合成和药物发现中的应用； (d) 发现具有特定目标的反应以应用于过渡金属化学； (e) 了解与人类健康和疾病有关的信号传导途径； (f) 探索具有各种应用的功能性和明确的大分子结构； (g) 研究多金属氧酸盐（POM）络合物和 POM 基材料及其作为催化剂的用途； (h) 开发传统惰性起始材料的选择性活化和功能化等合成方法； (i) 开发用于正电子发射断层扫描的小分子放射性示踪剂； (i) 研究药用植物的抗菌原理； (j) 发现治疗剂及其与靶蛋白相互作用的结构基础。

项目成果

Rh(II)-Catalyzed Monocyclopropanation of Pyrroles and Its Application to the Synthesis Pharmaceutically Relevant Compounds

• DOI: 10.1021/acs.orglett.9b02250
• 发表时间: 2019-08-02
• 期刊: ORGANIC LETTERS
• 影响因子: 5.2
• 作者: Fu, Jiantao;Wurzer, Nikolai;Davies, Huw M. L.
• 通讯作者: Davies, Huw M. L.

Copper(II) Acetate-Induced Oxidation of Hydrazones to Diazo Compounds under Flow Conditions Followed by Dirhodium-Catalyzed Enantioselective Cyclopropanation Reactions

乙酸铜 (II) 在流动条件下诱导腙氧化为重氮化合物，然后进行铑催化的对映选择性环丙烷化反应

• DOI: 10.1021/acs.orglett.1c01580
• 发表时间: 2021
• 期刊: Organic Letters
• 影响因子: 5.2
• 作者: Wei, Bo;Hatridge, Taylor A.;Jones, Christopher W.;Davies, Huw M.
• 通讯作者: Davies, Huw M.