Collaborative Research: Planning Grant: I/UCRC for Advanced Mammalian Biomanufacturing Innovation Center (AMBIC)

合作研究：规划补助金：I/UCRC 先进哺乳动物生物制造创新中心 (AMBIC)

• 批准号: 1464459
• 负责人: Sarah Harcum
• 金额: $ 1.15万
• 依托单位: Clemson University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1464459&HistoricalAwards=false
• 关键词: Collaborative; Research; Planning; Grant; UCRC

Johns Hopkins University, Clemson University, and the University of Delaware propose to form a new NSF-supported Industrial/University Cooperative Research Center (I/UCRC) entitled the Advanced Mammalian Biomanufacturing Innovation Center (AMBIC) to address current and future challenges faced by US bio-pharmaceuticals manufacturing. The Advanced Mammalian Biomanufacturing Innovation Center (AMBIC) will bring together leading academic, industrial, and government biotechnologists with the goal of advancing cell culture manufacturing innovation at a pre-competitive research level. AMBIC represents a unique opportunity to address technology challenges and bottlenecks in US biopharmaceutical manufacturing by bringing together leading researchers and innovators to implement transformative products and processes that will lead to a stronger, healthier, and more competitive biopharmaceutical industry. In this way, AMBIC will be a critical catalyst towards maintaining national excellence in biopharmaceutical production by focusing on mammalian cell culture issues. The three thrusts of AMBIC are as follows:1. Genome and Cellular Engineering of Mammalian Platform with the goal of developing advanced platforms with improved production capabilities.2.`Omics and Systems Biology for Mammalian Cells with the task of acquiring ?omics data and implementing standards of performance for the mammalian production platform3.Optimizing Bioreactor Control for Improved Cellular Performance with the objective of characterizing metabolic states and implementing advanced controls. This project will support the planning meeting to engage partners from the biopharmaceutical industry and government to participate in AMBIC and develop a research and educational program for the center. A planning meeting will help to identify major research challenges and to design a cutting edge research and educational program in mammalian biomanufacturing. Furthermore, AMBIC will establish and maintain a pipeline of educated and motivated students at all levels for careers in biopharmaceutical manufacturing and development. Collaborations with corporate partners will enable the students to work on the most pressing problems that the industry faces. In addition, AMBIC will serve to engage and excite students from under-represented minority populations to pursue a career in life sciences, engineering, or related STEM fields. Through systems biology analysis, novel cell line development, and bioreactor optimization, AMBIC will provide innovative solutions to improve biomanufacturing efficiencies. These advances will ultimately serve to lower overall health care costs for consumers and make biopharmaceuticals more affordable and available for a greater number of patients.

约翰霍普金斯大学、克莱姆森大学和特拉华大学提议成立一个由 NSF 支持的新工业/大学合作研究中心 (I/UCRC)，名为先进哺乳动物生物制造创新中心 (AMBIC)，以应对美国当前和未来面临的挑战生物制药制造。先进哺乳动物生物制造创新中心（AMBIC）将汇集领先的学术、工业和政府生物技术专家，目标是在竞争前的研究水平上推进细胞培养制造创新。 AMBIC 提供了一个独特的机会，通过汇集领先的研究人员和创新者来实施变革性产品和工艺，从而打造更强大、更健康和更​​具竞争力的生物制药行业，从而解决美国生物制药制造中的技术挑战和瓶颈。 通过这种方式，AMBIC 将通过专注于哺乳动物细胞培养问题，成为保持国家生物制药生产卓越性的关键催化剂。 AMBIC的三大主旨如下： 1．哺乳动物平台的基因组和细胞工程，目标是开发具有改进生产能力的先进平台。2.“哺乳动物细胞组学和系统生物学”，其任务是获取组学数据并实施哺乳动物生产平台的性能标准3.优化生物反应器提高细胞性能的控制，旨在表征代谢状态并实施先进的控制。该项目将支持规划会议，吸引生物制药行业和政府的合作伙伴参与 AMBIC 并为该中心制定研究和教育计划。 规划会议将有助于确定主要的研究挑战，并设计哺乳动物生物制造领域的前沿研究和教育计划。 此外，AMBIC 将建立并维持一个受过良好教育、积极进取的各级学生的管道，以从事生物制药制造和开发的职业。 与企业合作伙伴的合作将使学生能够解决行业面临的最紧迫的问题。 此外，AMBIC 将致力于吸引和激励少数族裔学生在生命科学、工程或相关 STEM 领域谋求职业生涯。通过系统生物学分析、新型细胞系开发和生物反应器优化，AMBIC 将提供创新解决方案来提高生物制造效率。 这些进步最终将有助于降低消费者的总体医疗保健成本，并使更多患者能够更负担得起和使用生物制药。