Collaborative Research: Kinetics of Autonomous Catalytic Nanomotors in Confined and Crowded Environments

合作研究：密闭和拥挤环境中自主催化纳米电机的动力学

• 批准号: 1464146
• 负责人: Rui Qiao
• 金额: $ 16.44万
• 依托单位: Virginia Polytechnic Institute and State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2017-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1464146&HistoricalAwards=false
• 关键词: Collaborative; Research; Kinetics; Autonomous; Catalytic

The objective of this project is to investigate the transport of autonomous nanomotors driven by chemical reactions in confined and crowded environments by integrating experiment and numerical simulations. Intellectual Merits: The work is built on the PIs? recent success in design and fabrication of catalytic nanomotors with translational and rotational motion. By elucidating new issues unique to the transport of autonomous nanomotors in confined spaces and in presence of other particles and motors with different thermal, mechanical, and chemical interactions, the proposed research will break new ground for fundamental studies of particulate transport phenomena and enrich the theories of particulate transport. The proposed work will benefit from the synergistic collaboration between two PIs with complementary expertise in nanomotor fabrication/characterization and multi-physics simulations, and is supported by state-of-the-art computing and experimental facilities. Broader Impacts: The proposed work addresses some of the most pressing issues in understanding the transport of nanomotors in practical applications, and the insights gained here will form the theoretical foundation for engineering smart nanomotor systems for targeted drug delivery and disease treatment, which can potentially transform these fields. The project will include strong and sustained education programs involving both undergraduate students with diverse ethnical backgrounds and regional K-12 students. Undergraduate research experience helps students, many of them minorities, develop a genuine interest in science and engineering through hands-on research activities in STEM disciplines. Outreach efforts will include providing high school students with immersive research experiences and showcasing research in university-level K-12 outreach programs. The interdisciplinary nature of this project, with a unique combination of experiments and simulations, will provide the students involved with a unique exposure to cutting-edge science and engineering.

该项目的目的是通过整合实验和数值模拟来研究在受限和拥挤的环境中化学反应驱动的自主纳米运动的运输。智力优点：工作是建立在PI上的？最近在设计和制造催化纳米运动方面取得了成功的成功。通过阐明在狭窄空间中自主纳米运动的运输独有的新问题，在存在具有不同热，机械和化学相互作用的其他颗粒和电动机的情况下，提出的研究将为颗粒传输现象的基本研究和丰富颗粒物转运的理论而构成新的基础。拟议的工作将受益于两个PI之间的协同合作，并在纳米运动制造/表征和多物理学模拟方面具有互补的专业知识，并得到最先进的计算和实验设施的支持。更广泛的影响：拟议的工作解决了了解实际应用中纳米运动的一些最紧迫的问题，此处获得的见解将构成用于靶向药物输送和疾病治疗的工程智能纳米运动系统的理论基础，这可能会改变这些领域。该项目将包括强大而持续的教育计划，涉及具有不同种族背景和地区K-12学生的本科生。 本科研究经验可以帮助学生（其中许多是少数群体）通过STEM学科的动手研究活动对科学和工程产生真正的兴趣。推广工作将包括为高中生提供沉浸式研究经验，并展示大学级别K-12外展计划的研究。该项目的跨学科性质与实验和模拟的独特组合将为参与的学生提供独特的尖端科学和工程。