I-Corps: Volatile Organic Compound Sensors using Conducting Polymer and Nanocomposite Blends deposited by Resonant Infrared, Matrix-Assisted Pulsed Laser Evaporation

I-Corps：使用通过共振红外、基质辅助脉冲激光蒸发沉积的导电聚合物和纳米复合材料混合物制成的挥发性有机化合物传感器

• 批准号: 1450511
• 负责人: Adrienne Stiff-Roberts
• 金额: $ 5万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1450511&HistoricalAwards=false
• 关键词: Corps; Volatile; Organic; Compound; Sensors

There is a large number of diabetics for whom a simple breath test to determine glucose abnormalities would be deemed superior to the current standard blood test. Development of a non-invasive method to monitor blood glucose that mirrors the accuracy of the painful blood test would revolutionize not only the lives of diabetics, but also the lives of the physicians who monitor their health. The painful blood test that is currently the standard monitoring method is potentially expensive, and it also deters regular monitoring of glucose - often with dangerous outcomes. It is especially dangerous for diabetics who have hypoglycemia unawareness, in which case, only the glucose test will alert the person to the dangerously low blood sugar levels that can lead to coma or even death.This work will develop gas sensors for detection of volatile organic compounds (VOCs) in exhaled human breath that act as biomarkers of internal bodily processes, specifically those processes existing uniquely in diabetes patients. The gas sensors comprise organic thin-films deposited by resonant infrared, matrix-assisted pulsed laser evaporation (RIR-MAPLE). RIR-MAPLE provides vastly increased processability and control over a large range of functional organic materials for which few methods exist to effectively fabricate films with nanoscale features.

对于许多糖尿病患者来说，确定血糖异常的简单呼气测试被认为优于当前的标准血液测试。 开发一种非侵入性血糖监测方法，反映痛苦的血液测试的准确性，不仅会彻底改变糖尿病患者的生活，还会改变监测他们健康的医生的生活。目前标准监测方法是痛苦的血液测试，其成本可能很高，而且还阻碍了对血糖的定期监测——通常会产生危险的结果。对于没有意识到低血糖的糖尿病患者来说尤其危险，在这种情况下，只有血糖测试才能提醒人们危险的低血糖水平，这可能导致昏迷甚至死亡。这项工作将开发用于检测挥发性有机物的气体传感器人类呼出的气体中的化合物（VOC）可作为体内过程的生物标志物，特别是糖尿病患者中独特存在的过程。气体传感器包含通过共振红外、基质辅助脉冲激光蒸发 (RIR-MAPLE) 沉积的有机薄膜。 RIR-MAPLE 极大地提高了可加工性和对多种功能性有机材料的控制，而对于这些材料，目前几乎没有方法可以有效地制造具有纳米级特征的薄膜。