EAGER: Lab-in-a-Smartphone

EAGER：智能手机实验室

• 批准号: 1447893
• 负责人: Brian Cunningham
• 金额: $ 30万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1447893&HistoricalAwards=false
• 关键词: EAGER; Lab; Smartphone

Proposal: 1447893PI: Cunningham, BrianInstitution: University of Illinois at Urbana-ChampaignTitle: EAGER: Lab-in-a-SmartphoneSignificance:The wide availability of a low-cost, robust, and multimode biosensor detection capability will spur accelerated development of sensing applications in myriad settings where laboratory capabilities are lacking, or where current closed platforms are aimed at only a very specific commercial market. Smartphone-based detection systems are expected to find applications in situations where laboratory facilities are not available such as point-of-care analysis in the home, clinic, farm, or remote locations. The integrated approach to be developed in the proposed work would enable mobile sensing applications that include diagnosis of disease through sensing of specific biomarker proteins (cardiac, cancer, and others), specific identification of infectious disease (viral or bacterial, as performed by PCR), sensing of allergens in food, food/drug manufacturing quality control, sensing of counterfeit drugs, breath analysis, and environmental monitoring of air/water/soil resourcesIntellectual Description:The goal of this EAGER proposal is to utilize integrated semiconductor laser diodes and LEDs as illumination sources within the smartphone, and a thin film waveguide/grating coupler to bring light to the sample. The system will operate simply by placing the sample-under-test over the analysis opening, while a custom software application controls all other aspects of the measurement. The resulting system will be capable of performing UV/Visible wavelength absorption spectroscopy, UV/Visible wavelength reflectance spectroscopy, Raman spectroscopy, surface-enhanced Raman spectroscopy, and label-free optical biosensor measurements. The platform will use custom microfluidic cartridges designed to perform sample preparation, liquid mixing, and other steps of cell/biomolecular assays that can be developed by the entire ecosystem of mobile application developers.

提案：1447893 PI：Cunningham，Brian 机构：伊利诺伊大学厄巴纳-香槟分校 标题：EAGER：智能手机实验室 意义：低成本、稳健和多模式生物传感器检测能力的广泛应用将刺激传感应用的加速发展在许多缺乏实验室能力的环境中，或者当前的封闭平台仅针对非常特定的商业市场。基于智能手机的检测系统预计将在实验室设施不可用的情况下得到应用，例如家庭、诊所、农场或偏远地区的现场护理分析。拟议工作中开发的综合方法将使移动传感应用成为可能，包括通过传感特定生物标志物蛋白（心脏、癌症等）来诊断疾病，特异性识别传染病（病毒或细菌，如通过 PCR 进行） 、食品中过敏原的传感、食品/药品制造质量控制、假药传感、呼吸分析以及空气/水/土壤资源的环境监测知识描述：该 EAGER 提案的目标是利用集成半导体激光二极管和 LED作为智能手机内的照明源，以及将光引入样品的薄膜波导/光栅耦合器。该系统只需将待测样品放在分析开口上即可运行，而定制软件应用程序则控制测量的所有其他方面。由此产生的系统将能够执行紫外/可见波长吸收光谱、紫外/可见波长反射光谱、拉曼光谱、表面增强拉曼光谱和无标记光学生物传感器测量。该平台将使用定制的微流体盒，旨在执行样品制备、液体混合以及细胞/生物分子测定的其他步骤，这些步骤可以由移动应用程序开发人员的整个生态系统开发。