MRI: Acquisition Of A Dual-Energy, 3-D X-Ray Microscope With Sub-Micron Resolution, Tunable Field Of View, and Phase Contrast

MRI：获取具有亚微米分辨率、可调视场和相衬的双能 3D X 射线显微镜

• 批准号: 1429068
• 负责人: Elise Morgan
• 金额: $ 42万
• 依托单位: Trustees of Boston University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-10-01 至 2015-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1429068&HistoricalAwards=false
• 关键词: MRI; Acquisition; Dual; Energy; Ray

PI: Morgan, Elise F.Proposal: 1429068Title: MRI: Acquisition Of A Dual-Energy, 3-D X-Ray Microscope With Sub-Micron Resolution, Tunable Field Of View, and Phase ContrastSignificance3-D X-ray microscopy (XRM) has recently emerged as a non-destructive imaging modality with unprecedented versatility for study of numerous types of materials and structures. Newly developed XRM systems overcome key limitations of older systems, including the rigid trade-off between specimen size and image resolution (fixed field of view), inability to consolidate image data obtained from multiple beam energies, and reliance on absorption contrast as the only mode of imaging. As a result, XRM is now viable for a host of new and diverse applications in engineering and natural sciences. The XRM instrument for which funds are requested in this proposal is extremely well suited for fostering the integration of research and education. This instrument generates rich data sets via user-friendly software and hardware interfaces. These data, which include high-resolution 3-D renderings, cross-sectional views, and quantitative structural measures, are amenable to research projects and class assignments for students at multiple levels.Technical DescriptionThe research activities that will use this instrumentation address fundamental physical and biological phenomena in biomechanics, tissue engineering, skeletal and evolutionary biology, microfluidics, earth science, complex fluids, and high-temperature materials. Currently, these research activities use multiple methods, most of which are 2-D and/or destructive, to quantify microstructure and composition. The requested XRM instrument would add a new and profoundly enabling dimension to this existing armamentarium. This instrument generates rich data sets via user-friendly software and hardware interfaces. The data includes high-resolution 3-D renderings, cross-sectional views, and quantitative structural measures.

PI：Morgan，Elise F.Proposal：1429068title：MRI：以亚微米的分辨率，可调的观点和相位对比度3-D-D-D X射线显微镜（XRM）的材料的材料和综合材料的范围，获得了次要的观点和相比X射线显微镜（XRM），并获得了材料，并具有多种材料的范围，并获得了相反的观点，并获得了相反的观点和相位对比度，并获得了多种材料，并获得了相反，结构。新开发的XRM系统克服了较旧系统的关键局限性，包括样品大小和图像分辨率（固定视野）之间的严格权衡，无法巩固从多个光束能量获得的图像数据，以及依赖对吸收对比度作为唯一成像模式。结果，XRM现在可为许多新的和多样化的工程和自然科学应用程序可行。 该提案中要求资金的XRM工具非常适合促进研究和教育的整合。该仪器通过用户友好的软件和硬件接口生成丰富的数据集。这些数据包括高分辨率3-D渲染，横截面的观点和定量结构测量，可与多个级别的学生进行研究项目和课堂作业。技术描述研究活动，这些研究活动将使用此仪器介绍基本的物理和生物学现象，在生物力学，组织工程，骨架和进化生物学，Microfers and Commenteric，Microfrics，Microfers，Squondsscions，Scientry，Microfterssconcodics，Microftersscompords，Microfsector，Microfterssciptersconsconics，Microfsectry and Commenty conscient，Squondsscipty，Seracon，Squondssciptry中。当前，这些研究活动使用多种方法，其中大多数是2-D和/或破坏性的，以量化微观结构和组成。所请求的XRM仪器将为现有的Armammentium添加一个新的且极端的维度。该仪器通过用户友好的软件和硬件接口生成丰富的数据集。数据包括高分辨率3-D渲染，横截面视图和定量结构措施。