Syntheses, Anion Recognition and Self-assemblies of Cyanostilbene Receptors

氰芪受体的合成、阴离子识别和自组装

• 批准号: 1412401
• 负责人: Amar Flood
• 金额: $ 38.47万
• 依托单位: Indiana University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1412401&HistoricalAwards=false
• 关键词: Syntheses; Anion; Recognition; Self; assemblies

The long term goal of this project is to address one of the grand challenges in the chemical sciences: How to design and perfect the atom- and energy-efficient synthesis of new forms of matter with tailored properties. To this end, Dr. Amar H. Flood at Indiana University seeks knowledge of how to design star-shaped molecules bearing holes in their centers to recognize and hold unique classes of negatively charged anions that were once considered too large to catch. By doing so, this research and these molecules can have impacts in removing toxic anions from contaminated water or manipulating anions important for human health. In addition, his research team investigates how star-shaped structures can be designed to self-assemble and fit together to form larger assemblies, e.g., nanometer-sized, soccer-ball shaped architectures. He aims to unfold the rules of their self-assembly because molecules cannot be picked and placed together like a lego set. Such materials could have impacts in compartmentalized chemical catalysis and for gated drug delivery. Broader impact activities of the project include training of graduate and undergraduate students, using 3D printing to teach principles of self-assembly, and developing strategies to increase the participation and visibility of under-represented minorities and women at conferences organized by Dr. Flood.Under the support of the Macromolecular, Supramolecular and Nanochemistry Program of NSF, Dr. Flood seeks to develop the syntheses of polycyanostilbene macrocycles called "cyanostars" for binding anions (e.g., biorelevant phosphates), and understand fundamentally how non-covalent interactions (such as CH H-bonding) and solvophobic effects influence anion binding. Furthermore, he explores the use of cyanostars in rotaxanes that can switch between states and in novel self-assembled architectures that stem from anion templation and 5-fold symmetry.

该项目的长期目标是解决化学科学中的宏伟挑战之一：如何设计和完善具有量身定制特性的新形式物质的原子和节能合成。为此，印第安纳大学的Amar H. Flood博士寻求有关如何在其中心设计带有孔的星形分子的知识，以识别并拥有曾经被认为太大而无法捕捉的带有负电荷的阴离子的独特类别。通过这样做，这项研究和这些分子可以从污染的水中去除有毒阴离子或操纵对人类健康重要的阴离子的影响。此外，他的研究小组研究了如何设计出恒星形状结构以自组装和结合在一起，以形成较大的组件，例如纳米尺寸的足球形状体系结构。他的目标是展开他们自组装的规则，因为不能像乐高积木一样挑选分子并将其放在一起。这样的材料可能会影响分隔化的化学催化和封闭式药物输送。该项目的更广泛的影响活动包括对研究生和本科生的培训，使用3D打印来教授自组装原则，并制定策略，以增加洪水博士组织的会议上代表性不足的少数群体和妇女的参与和可见性。大环为结合阴离子（例如生物硫化磷酸盐），并从根本上理解非共价相互作用（例如CH H键）和溶vophopic效应影响阴离子结合的大环。此外，他还探索了在旋转烷中使用蓝果的使用，这些蓝果会可以在状态和新型的自组装架构之间切换，这些结构源于阴离子模板和5倍对称性。