Collaborative Research: Understanding the Design Principles of Modular Nanopores for Highly Efficient Chemical Sensing

合作研究：了解模块化纳米孔的设计原理以实现高效化学传感

• 批准号: 1709625
• 负责人: Amar Flood
• 金额: $ 23.4万
• 依托单位: Indiana University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2022-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1709625&HistoricalAwards=false
• 关键词: Collaborative; Research; Understanding; Design; Principles

This project is funded by the Chemical Measurement and Imaging Program of the Chemistry Division. Professor Takashi Ito of Kansas State University, and Professor Amar Flood, and Dr. Yi Yi, both from Indiana University - Bloomington seek to design cylindrical nanoscale pores (pores 10-40 nanometers in diameter and 30-100 nanometers in length; there are 25,400,000 nanometers in one inch) for efficient chemical separations and detection. Chloride ion is used as the model target. This work examines how chloride can be chemically recognized by the nanopore geometry and physical environment. It is hypothesized that selectivity, specificity, and strength of chemical recognition can be enhanced by adjusting the environment and charge inside the nanopores. The control of the nanopore physical interior for chemical recognition can be a versatile, basic principle for designing highly efficient separations for various species, including those of environmental interest such as chemicals in fertilizers. A direct societal impact of improved anion sensing is improvement in water purification and analysis. Microscale anion sensors for measurements within the body are also being pursued. These research achievements are integrated with educational activities by developing a new hands-on polymer lab course that includes both polymer synthesis and characterization. Systematic investigations explore polymer-based cylindrical nanopores (10-40 nm in pore diameter; 30-100 nm in pore length) to assess the effects of nanopore physical environment on chemical recognition and redox-involved charge transport. Nanopores decorated with surface alkyne groups are covalently modified with various azide-tagged anion receptors and redox moieties. The fundamental understanding of the nanopore design principles present an approach to rationally fabricate monolithic nanoporous membranes and films for efficient chemical separations and detection. The research focuses on the fabrication and characterization of alkyne-decorated nanoporous scaffolds with controlled pore orientation and dimensions. This is followed by understanding of the effects of nanopore's physical environment on anion recognition and charge transport. The third area of research is the redox-controlled anion sensing. The anion recognition and electrochemical properties of modular nanopores are assessed using spectroscopic and electrochemical techniques. The investigators have complementary expertise for this interdisciplinary project: electrochemistry and spectroscopy on nanostructured films (Ito), design, synthesis and characterization of anion receptors with "click" reactions (Flood), and block copolymer synthesis (Yi). Results obtained in this project provide fundamental knowledge required to design better chemical sensing media of inorganic ions which are of special importance in water quality control and biosciences.

该项目由化学部化学测量和成像项目资助。堪萨斯州立大学的 Takashi Ito 教授、印第安纳大学伯明顿分校的 Amar Flood 教授和 Yi Yi 博士寻求设计圆柱形纳米级孔隙（孔隙直径为 10-40 纳米，长度为 30-100 纳米；有 25,400,000 个）一英寸纳米）用于高效的化学分离和检测。使用氯离子作为模型目标。这项工作研究了氯化物如何通过纳米孔几何形状和物理环境进行化学识别。据推测，通过调整纳米孔内的环境和电荷可以增强化学识别的选择性、特异性和强度。用于化学识别的纳米孔物理内部控制可以成为设计各种物种高效分离的通用基本原理，包括那些具有环境意义的物种，例如化肥中的化学品。改进的阴离子传感的直接社会影响是水净化和分析的改进。用于体内测量的微型阴离子传感器也在研究中。通过开发新的聚合物实验实践课程（包括聚合物合成和表征），将这些研究成果与教育活动相结合。系统研究探索基于聚合物的圆柱形纳米孔（孔径10-40 nm；孔长30-100 nm），以评估纳米孔物理环境对化学识别和氧化还原涉及的电荷传输的影响。表面炔基修饰的纳米孔被各种叠氮化物标记的阴离子受体和氧化还原部分共价修饰。对纳米孔设计原理的基本理解提出了一种合理制造整体纳米孔膜和薄膜的方法，以实现有效的化学分离和检测。该研究重点是具有受控孔方向和尺寸的炔装饰纳米多孔支架的制造和表征。接下来是了解纳米孔的物理环境对阴离子识别和电荷传输的影响。第三个研究领域是氧化还原控制的阴离子传感。使用光谱和电化学技术评估模块化纳米孔的阴离子识别和电化学特性。研究人员在这个跨学科项目中拥有互补的专业知识：纳米结构薄膜的电化学和光谱学 (Ito)、具有“点击”反应的阴离子受体的设计、合成和表征 (Flood) 以及嵌段共聚物合成 (Yi)。该项目获得的结果提供了设计更好的无机离子化学传感介质所需的基础知识，这在水质控制和生物科学中特别重要。