Collaborative Research: Understanding the Design Principles of Modular Nanopores for Highly Efficient Chemical Sensing

合作研究：了解模块化纳米孔的设计原理以实现高效化学传感

• 批准号: 1709625
• 负责人: Amar Flood
• 金额: $ 23.4万
• 依托单位: Indiana University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2022-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1709625&HistoricalAwards=false
• 关键词: Collaborative; Research; Understanding; Design; Principles

This project is funded by the Chemical Measurement and Imaging Program of the Chemistry Division. Professor Takashi Ito of Kansas State University, and Professor Amar Flood, and Dr. Yi Yi, both from Indiana University - Bloomington seek to design cylindrical nanoscale pores (pores 10-40 nanometers in diameter and 30-100 nanometers in length; there are 25,400,000 nanometers in one inch) for efficient chemical separations and detection. Chloride ion is used as the model target. This work examines how chloride can be chemically recognized by the nanopore geometry and physical environment. It is hypothesized that selectivity, specificity, and strength of chemical recognition can be enhanced by adjusting the environment and charge inside the nanopores. The control of the nanopore physical interior for chemical recognition can be a versatile, basic principle for designing highly efficient separations for various species, including those of environmental interest such as chemicals in fertilizers. A direct societal impact of improved anion sensing is improvement in water purification and analysis. Microscale anion sensors for measurements within the body are also being pursued. These research achievements are integrated with educational activities by developing a new hands-on polymer lab course that includes both polymer synthesis and characterization. Systematic investigations explore polymer-based cylindrical nanopores (10-40 nm in pore diameter; 30-100 nm in pore length) to assess the effects of nanopore physical environment on chemical recognition and redox-involved charge transport. Nanopores decorated with surface alkyne groups are covalently modified with various azide-tagged anion receptors and redox moieties. The fundamental understanding of the nanopore design principles present an approach to rationally fabricate monolithic nanoporous membranes and films for efficient chemical separations and detection. The research focuses on the fabrication and characterization of alkyne-decorated nanoporous scaffolds with controlled pore orientation and dimensions. This is followed by understanding of the effects of nanopore's physical environment on anion recognition and charge transport. The third area of research is the redox-controlled anion sensing. The anion recognition and electrochemical properties of modular nanopores are assessed using spectroscopic and electrochemical techniques. The investigators have complementary expertise for this interdisciplinary project: electrochemistry and spectroscopy on nanostructured films (Ito), design, synthesis and characterization of anion receptors with "click" reactions (Flood), and block copolymer synthesis (Yi). Results obtained in this project provide fundamental knowledge required to design better chemical sensing media of inorganic ions which are of special importance in water quality control and biosciences.

该项目由化学分部的化学测量和成像程序资助。印第安纳大学 - 布卢明顿（Bloomington）寻求设计圆柱纳米级毛孔（直径10-40纳米，长度为30-100纳米的毛孔，长度为25,400,000英寸的纳米纳米），有25,400,000纳米分离的化学分离，堪萨斯州立大学教授和阿马尔·弗林教授和阿玛尔洪水教授和阿玛尔·弗林教授和Yi Yi博士。氯离子用作模型目标。这项工作研究了纳米孔几何形状和物理环境如何化学识别氯化物。假设可以通过调整纳米孔内的环境和电荷来增强化学识别的选择性，特异性和强度。对化学识别的纳米孔物理内部的控制可能是为各种物种设计高效分离的多功能，基本原理，包括具有环境兴趣的物种，例如化学剂中的化学物质。改善阴离子感测的直接社会影响是净水和分析的改善。还正在追求微观的阴离子阴离子传感器进行测量。通过开发包括聚合物合成和表征的新的动手聚合物实验室课程，这些研究成就与教育活动融为一体。系统的研究探索了基于聚合物的圆柱纳米孔（孔径10-40 nm；孔长30-100 nm），以评估纳米孔物理环境对化学识别和氧化还原电荷电荷转运的影响。用各种叠氮化物的阴离子受体和氧化还原部分对用表面炔烃组装饰的纳米孔进行了共价修饰。对纳米孔设计原理的基本理解提出了一种合理构建单片纳米方膜和膜的方法，以进行有效的化学分离和检测。该研究的重点是具有受控孔隙方向和尺寸的炔烃装饰的纳米孔支架的制造和表征。接下来是了解纳米孔的物理环境对阴离子识别和电荷运输的影响。研究的第三个领域是氧化还原控制的阴离子传感。使用光谱和电化学技术评估模块化纳米孔的阴离子识别和电化学特性。研究人员对这个跨学科项目具有互补的专业知识：纳米结构膜的电化学和光谱法（ITO），设计，合成和表征带有“点击”反应（洪水）和阻止共聚物合成（YI）的阴离子受体的表征。在该项目中获得的结果提供了设计的基本知识，以设计更好的无机离子化学传感介质，这些介质在水质控制和生物科学中特别重要。