Engineering Membrane Platforms Based on Active Transporter Architectures

基于主动转运体架构的工程膜平台

• 批准号: 1403750
• 负责人: Bruce Hinds
• 金额: $ 28.63万
• 依托单位: University of Kentucky Research Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1403750&HistoricalAwards=false
• 关键词: Engineering; Membrane; Platforms; Based; Active; Engineering; Membrane; Platforms; Based; Active

1403750HindsUniversity of KentuckyCurrent membrane technology is based primarily on pore size and chemical functionality. Naturally occurring protein channels far exceed any man-made engineering pores with selectivities exceeding parts per million and flow rates 10,000 fold faster. The PI proposes to imitate natural protein channel structures and nanometer scale electrode geometries to increase flow. If successful, this could potentially revolutionize membrane function by providing a solution to the long standing trade-off between high chemical selectivity and high processing rate. Two promising material platforms are Carbon Nanotube (CNT) Membranes and nm-scale electrode multilayers on anodized aluminum oxide (AAO). There are three key attributes unique to Carbon Nanotube (CNT) membranes: 1) atomically flat hydrophobic graphitic core that induces a near perfect slip layer for dramatic fluid flow 2) functional chemistry by necessity is at the cut entrances to the CNT cores for gatekeeper activity and 3) CNTs are conductive allowing for electrochemical transformation and application of electric field. Needed is a method to generate fluid flow (with chemical interaction or selectivity) in the entrance to CNT pores and have the plug flow rapidly transfer down the fast CNT core. Electro-osmotic pumping is found to have similar flow enhancements as pressure driven pumping and can accelerate selectively bound species within plug flow Peptide libraries allow the screening of 109 peptide combinations to find highly selective affinity chemistry far beyond what is achieved with simple coordination chemistry. However, strong binding coefficients result in kinetics too slow for monolayer-based pumping cycles. The PIs have found that modest voltages are sufficient to release cationic bound rare-earth ions, from high surface area conductive AAO surface. Multilayer electrodes allow for pumping cycles to direct strong electric fields in a high porosity AAO system. This allows for a very general separation system based on rapid cycles of binding targets to specific peptides at the pore entrances followed by electrostatic release pumping across the membrane. Due to the large breadth of peptide affinity libraries, this concept is applied to a large number of commercially relevant applications in energy storage, energy processing, chemical sensors, selective pharmaceutical separations, drug delivery and water purification. Support of this research area will enable many educational opportunities related to novel nanometer scale materials fabrication, characterization and application into separations science and engineering.

肯塔基州膜技术的1403750Hindsuniversity主要基于孔径和化学功能。天然发生的蛋白质通道远远超过了任何人造工程毛孔，其选择性超过零件，而流速速度更快10,000倍。 PI建议模仿天然蛋白质通道结构和纳米尺度电极几何形状以增加流量。如果成功，这可能会通过为高化学选择性和高处理速率之间的长期折衷提供解决方案，从而有可能彻底改变膜功能。两个有希望的材料平台是氧化铝（AAO）上的碳纳米管（CNT）膜和NM尺度电极多层。碳纳米管（CNT）膜特有的三个关键特性：1）原子上平坦的疏水石墨核心，可诱导近乎完美的滑动层，以实现戏剧性流体流动2）必要的功能化学是在CNT核心的切入入口处进行CNNEPECTER ACTERAICE ACTAINEPER ACTIONALICT和3）CNTS可用于电力和应用电源转换和应用电力转换。所需的方法是在CNT孔入口处产生流体流（具有化学相互作用或选择性）的方法，并使插头流迅速向下传递快速CNT CONT核心。发现电渗水泵具有与压力驱动泵的相似的流动增强，并且可以在插头流肽文库中加速有选择性的结合物种，允许筛选109个肽组合，可以找到高度选择性的亲和力化学，远远超出了简单的坐标化学。然而，强的结合系数导致基于单层的抽水周期的动力学太慢。 PIS发现，适中的电压足以从高表面积导电AAO表面释放阳离子结合的稀土离子。多层电极允许泵送循环在高孔隙率AAO系统中引导强电场。这允许在孔隙入口处与特定肽的结合靶标的快速循环，然后在整个膜上泵送静电释放。由于肽亲和力库的广度，该概念适用于大量商业相关的应用，在能量储存，能量处理，化学传感器，选择性药物分离，药物输送和水纯化中。该研究领域的支持将使许多与新的纳米尺度材料制造，表征和应用于分离科学和工程的教育机会。