Advances of Methodology and Design for the Synthesis of Complex Polycyclic Natural Products

复杂多环天然产物的合成方法与设计进展

• 批准号: 1362561
• 负责人: David Williams
• 金额: $ 45万
• 依托单位: Indiana University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-15 至 2017-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1362561&HistoricalAwards=false
• 关键词: Advances; Methodology; Design; Synthesis; Complex

This project funded by the Chemical Catalysis program of the Chemistry Division of the NSF investigates organometallic complexes in order to discover new reaction methods and reactivity. These advances are sought in order to streamline the efficiencies of chemical pathways for the rapid assembly of complex molecules. A key aspect of these efforts seeks to define versatile, high-value methods for the construction of bioactive compounds to create a platform for studies of medicinal chemistry. Specific aspects of the research examine the development of new reactions involving complexes of iron, indium and palladium. These studies are applied in the synthesis of natural products which display promising bioactivity toward various cancers and disease models of inflammation. Because of current limitations of the science, the natural products proposed in this investigation have not been previously prepared by synthesis. Therefore, success in this program is advancing the design and study of these substances as potential drug-like molecules. A goal of this research is to create new methodologies for generally useful cross-coupling reactions to produce chemically reactive allenes, and to design new carbocyclization reactions. These efforts are directly applied toward the synthesis of daphnicyclidin and tetrapetalone natural products, but also have broader applicability.This University laboratory offers state-of-the-art training and mentoring in the field of synthetic organic chemistry with a significant diversity program. A blend of predoctoral students, postdoctoral fellows, and undergraduate participants emphasizes the inclusion of women and underrepresented minorities. All individuals receive training and mentoring to enable future opportunities as leading scientists of the next generation. The broader impact of these scientific results benefit society by enabling the discovery of new pharmaceuticals.

该项目由NSF的化学催化计划资助，研究有机金属络合物，以发现新的反应方法和反应性。 寻求这些进步，以简化化学途径快速组装复合分子的效率。 这些努力的一个关键方面旨在定义用于构建生物活性化合物的多功能高价值方法，以创建用于研究药物化学的平台。研究的特定方面检查了涉及铁，依赖和钯的复合物的新反应的发展。 这些研究应用于天然产物的合成，这些天然产物对各种癌症和疾病模型表现出有希望的生物活性。 由于科学的当前局限性，此研究中提出的天然产物先前尚未通过合成制备。 因此，该程序的成功正在推进这些物质作为潜在类似药物样分子的设计和研究。 这项研究的目的是创建新的方法，用于通常有用的交叉偶联反应，以产生化学反应性艾伦，并设计新的碳环化反应。 这些努力直接用于合成二维霉素和四脑天然产品，但也具有更广泛的适用性。该大学实验室在合成有机化学领域提供了具有重要多样性计划的合成有机化学领域的最先进培训和指导。 融合了专业学生，博士后研究员和本科参与者的融合，强调了妇女的包容性和代表性不足的少数民族。 所有人都接受培训和指导，以使未来成为下一代领先科学家的机会。 这些科学结果的广泛影响通过实现新药的发现使社会受益。