CAREER: Design Automation for Microfluidic Large Scale Integration Laboratories-on-a-Chip

职业：微流控大规模集成片上实验室的设计自动化

• 批准号: 1351115
• 负责人: Philip Brisk
• 金额: $ 49.36万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-03-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1351115&HistoricalAwards=false
• 关键词: CAREER; Design; Automation; Microfluidic; Large

Emerging laboratory-on-a-chip technology enables automation and miniaturization of biochemical reactions for applications such as DNA sequencing, drug discovery, detection of influenza and other pathogens, biothreat detection, and water purification. Scientists presently must design new devices for each application by hand. This may take weeks or months for complex applications. This project will design and implement computer software that automatically converts a scientist's biological application into a physical device layout that can be fabricated. Successful completion of this project will enhance scientific productivity and lower the barrier-to-entry for new users. In terms of broader impact, laboratories-on-a-chip are expected to improve and reduce the cost of global healthcare, particularly through point-of-care testing. This project will reduce the design cost for laboratories-on-a-chip through productivity enhancements, and these savings can be passed directly to the consumer. At the University of California, Riverside, the PI will introduce undergraduate and graduate courses on laboratory-on-a-chip technology, which will be assessed by a qualified professional development officer. The PI will include women and underrepresented minority students in this project, and has a planned an outreach program with a collaborator at Crafton Hills College to promote computer science education to underrepresented minority high school students in the economically-disadvantaged Inland Empire region of Southern California.

新兴实验室在芯片上技术可以实现生化反应的自动化和微型化，例如DNA测序，药物发现，流感和其他病原体的检测，生物治疗检测和净水。目前，科学家必须手动为每个应用程序设计新设备。复杂的应用可能需要数周或几个月的时间。该项目将设计和实施计算机软件，该软件软件将自动将科学家的生物应用转换为可以制造的物理设备布局。该项目的成功完成将提高科学生产力，并降低新用户的障碍。在更广泛的影响方面，芯片上的实验室有望改善并降低全球医疗保健的成本，尤其是通过护理点测试。该项目将通过提高生产力降低芯片实验室的设计成本，这些节省可以直接传递给消费者。在加利福尼亚大学河滨分校，PI将在芯片上实验室介绍本科和研究生课程，该课程将由合格的专业发展官员评估。 PI将包括该项目中的女性和代表性不足的少数族裔学生，并计划与Crafton Hills College的一名合作者进行外展计划，以促进计算机科学教育，以在南加州南加州地区经济上偏用的内陆帝国地区的代表性不足的少数族裔高中学生。

项目成果

Reducing Microfluidic Very Large Scale Integration (mVLSI) Chip Area by Seam Carving

• DOI: 10.1145/3060403.3060461
• 发表时间: 2017-05
• 期刊: Proceedings of the Great Lakes Symposium on VLSI 2017
• 作者: Brian Crites;Karen Kong;P. Brisk

ChemStor: Using Formal Methods To Guarantee Safe Storage and Disposal of Chemicals

ChemStor：使用正式方法保证化学品的安全存储和处置

• DOI: 10.1021/acs.jcim.9b00951
• 发表时间: 2020
• 期刊: Journal of Chemical Information and Modeling
• 影响因子: 5.6
• 作者: Ott, Jason;Tan, Daniel;Loveless, Tyson;Grover, William H.;Brisk, Philip
• 通讯作者: Brisk, Philip

The case for semi-automated design of microfluidic very large scale integration (mVLSI) chips

微流控超大规模集成（mVLSI）芯片半自动化设计案例

• DOI: 10.23919/date.2017.7927283
• 发表时间: 2017
• 期刊: Design Automation and Test in Europe
• 作者: McDaniel, Jeffrey;Grover, William H.;Brisk, Philip
• 通讯作者: Brisk, Philip

Chronoprints: Identifying Samples by Visualizing How They Change over Space and Time

Chronoprints：通过可视化样本随空间和时间的变化来识别样本

• DOI: 10.1021/acscentsci.8b00860
• 发表时间: 2019
• 期刊: ACS Central Science
• 影响因子: 18.2
• 作者: McKenzie, Brittney A.;Robles-Najar, Jessica;Duong, Eric;Brisk, Philip;Grover, William H.
• 通讯作者: Grover, William H.

A compiler for cyber-physical digital microfluidic biochips

网络物理数字微流控生物芯片编译器

• DOI: 10.1145/3168826
• 发表时间: 2018
• 期刊: Proceedings of the 2018 International Symposium on Code Generation and Optimization - CGO 2018
• 作者: Curtis, Christopher;Grissom, Daniel;Brisk, Philip
• 通讯作者: Brisk, Philip