CAREER: Catalytic C-C Bond Formation and Cleavage at Cobalt: Mechanism, Origins and Application

职业：钴催化 C-C 键形成和断裂：机制、起源和应用

• 批准号: 1350047
• 负责人: Wesley Bernskoetter
• 金额: $ 65万
• 依托单位: Brown University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2015-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1350047&HistoricalAwards=false
• 关键词: CAREER; Catalytic; Bond; Formation; Cleavage

In this CAREER award funded by the Chemical Catalysis Program of the Chemistry Division, Professor Wesley Bernskoetter from Brown University is investigating the mechanistic pathways and origins of selective two-electron, carbon-carbon bond transformations at earth abundant metals. In particular, strong field cobalt complexes that mediate carbon-carbon bond reductive elimination and oxidative addition reactions necessary for catalytic applications are being targeted. These fundamental studies examine factors such as ligand field strength, spin state interconversion, and coordination geometry, which may influence the rate and selectivity of these transformations. This research will further the utilization of base-metals as surrogates for platinum group metal catalysis in reactions ranging from cross-coupling to carbocyanation. In concert with the research endeavors, this project is enhancing the training of undergraduate students through peer mentoring and tutorials as well as through a discovery-based introduction to physical sciences for pre-college students. A variety of manufacturing industries rely on metal-based catalysis to produce chemicals and materials in an energy efficient and cost-effective manner. The past decades have witnessed a significant growth in the number of important new catalytic reactions promoted by metal catalysts; however, the metals employed in these discoveries have largely come from a group of expensive, rare, and toxic metals. This research project seeks to develop routes to accomplish some of the same important catalytic reactions using metals that are much more abundant, less expensive, and potentially less toxic. Future impacts of the work could include the development of more economical and sustainable manufacturing technologies. This project will also include professional training for the next generation of research scientists and opportunities for pre-college students to discover the important place of science in society.

在化学部化学催化计划资助的职业奖中，布朗大学的卫斯理·伯恩斯科特教授正在研究选择性两电子的机械途径和起源，地球丰富金属的碳碳键转换。 特别是，介导碳键还原性消除的强场钴复合物和催化应用所需的氧化添加反应是针对的。 这些基本研究检查了配体场强，旋转状态互连和协调几何形状等因素，这些因素可能影响这些转换的速率和选择性。 这项研究将进一步利用碱金属作为铂金属金属催化的替代反应，范围从交叉偶联到碳苯二烷。 在与研究努力的一致之间，该项目正在通过同伴指导和教程以及通过针对大学前学生进行基于发现的物理科学介绍来增强本科生的培训。 各种制造业依靠基于金属的催化来以节能且具有成本效益的方式生产化学物质和材料。 过去几十年来，金属催化剂促进的重要新催化反应的数量显着增长。但是，这些发现中使用的金属主要来自一群昂贵，稀有和有毒的金属。 该研究项目旨在使用更丰富，更便宜且可能较小的毒性的金属来开发一些相同重要的催化反应的路线。 这项工作的未来影响可能包括开发更经济和可持续的制造技术。 该项目还将包括针对下一代研究科学家的专业培训，以及前大学学生发现社会上重要地位的机会。