CAREER: Iron mediated catalytic C-H bond functionalization

职业：铁介导的催化 C-H 键功能化

• 批准号: 0955885
• 负责人: Theodore Betley
• 金额: $ 60万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-15 至 2015-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0955885&HistoricalAwards=false
• 关键词: CAREER; Iron; mediated; catalytic; bond

The Chemical Catalysis Program supports the efforts of Professor Theodore Betley of Harvard University on iron-mediated, catalytic carbon-hydrogen (C-H) bond functionalization. Professor Betley's group synthesizes electrophilic complexes featuring transiently-formed metal-ligand multiple bonds. These metal catalysts contain hard donor, weak-field dipyrromethane and tris(pyrrolyl)ethane ligand scaffolds that were selected for their ability to confer a wide range of steric and electronic environments to the first row-transition metal ion. Catalytic C-H bond amination reactions are being explored to determine the scope, activity, and mechanisms of the reaction.This award examines the activation of carbon-hydrogen bonds as a way of converting inexpensive chemical feedstocks (hydrocarbons) to valuable functional molecules with minimal waste generation. Importantly, Professor Betley and his group are using non-toxic and earth-abundant elements, such as iron, to perform these important transformations. The targeted products are useful in many fields, ranging from pharmaceutical production to value-added commodity chemicals for buildings and automobiles. This research effort is well-integrated into the classroom. Professor Betley organizes the Experience the Elements Firsthand, an interactive demonstration for students at the K-12 level from Boston's local grade schools and high schools. In this program, the students are invited to participate in a series of experiments and observe chemical phenomena in the laboratory. Professor Betley also co-directs an academic outreach program aimed at attracting traditionally underrepresented minority students in the chemical sciences and is active in Hawaii's federally-funded Upward-Bound program to promote interest in the sciences in first-generation students.

化学催化计划支持哈佛大学 Theodore Betley 教授在铁介导的催化碳氢 (C-H) 键功能化方面的努力。 Betley 教授的团队合成了具有瞬时形成的金属-配体多重键的亲电配合物。 这些金属催化剂含有硬供体、弱场二吡咯甲烷和三(吡咯基)乙烷配体支架，这些支架因其能够为第一行过渡金属离子赋予广泛的空间和电子环境的能力而被选择。 正在探索催化 C-H 键胺化反应，以确定反应的范围、活性和机制。该奖项研究了碳-氢键的活化作为一种​​将廉价化学原料（碳氢化合物）转化为有价值的功能分子、同时产生最少废物的方法。 重要的是，贝特利教授和他的团队正在使用无毒且地球丰富的元素（例如铁）来进行这些重要的转变。 目标产品适用于许多领域，从药品生产到建筑和汽车的增值日用化学品。 这项研究工作很好地融入了课堂。 Betley 教授为波士顿当地小学和高中的 K-12 级别学生组织了“亲身体验元素”互动演示活动。 在这个项目中，学生被邀请参加一系列实验并在实验室中观察化学现象。 贝特利教授还共同指导了一项学术推广计划，旨在吸引传统上在化学科学领域代表性不足的少数族裔学生，并积极参与夏威夷联邦政府资助的向上发展计划，以提高第一代学生对科学的兴趣。