Collaborative Research: Fate, Transport, and Organismal Uptake of Rod-Shaped Nanomaterials

合作研究：棒状纳米材料的命运、运输和生物摄取

• 批准号: 1336353
• 负责人: Peter Vikesland
• 金额: $ 12.08万
• 依托单位: Virginia Polytechnic Institute and State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-10-01 至 2017-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1336353&HistoricalAwards=false
• 关键词: Collaborative; Research; Fate; Transport; Organismal

CBET 1336353There is currently very little known about the environmental implications of rigid highly anisotropic nanostructures. Nanorods possessing high aspect ratios (AR = length:diameter) are an exciting nanomaterial class with many potential applications. To date, however, only a limited number of studies have examined the environmental fate of these elongated nanomaterials. The lack of work in this area is particularly surprising given that it has been definitively shown that anisotropy affects how nanorods interact with biological systems. The underlying hypothesis driving the present effort is that changes in AR and surface chemistry will alter the mechanisms and kinetics dictating nanorod fate in riverine systems. To test this hypothesis the PIs have developed a research plan that consists of four highly inter-related project tasks: In Task 1 we will synthesize gold nanorods with varying AR and we will then functionalize them using a range of environmentally relevant metal oxides (e.g., SiO2, gamma-Fe2O3, CeO2) to obtain a suite of nanomaterials that exhibit both shape and surface chemical heterogeneity. These nanorods will then be used in studies to evaluate nanorod aggregation (Task 2), nanorod deposition (Task 3), and uptake by the filter feeding bivalve Corbicula fluminea (Task 4). Completion of each of these tasks is an important undertaking in its own right; however, we have developed a cohesive research plan in which the knowledge gained in any one task is used to help refine the overall research plan.Intellectual Merit :Anisotropic nanoparticles are being produced in an ever-expanding variety of shapes and sizes in ever-increasing quantities. Presently ery little is known about the environmental implications of these highly complex nanomaterials. The effort proposed herein will provide a fundamental basis for the description of how material anisotropy dictates nanomaterial fate in environmental matrices. The expected intellectual outcomes of this effort are i) systematic examination of nanorod aggregation kinetics and fractal dimension as a function of aspect ratio and solution chemistry (ii) delineation of deposition mechanisms by the systematic variation of particle properties (AR, surface chemistry) and collector parameters (e.g., collector size and surface roughness) in column studies; and (iii) quantification of the effects of AR on nanomaterial uptake by the ubiquitous filter feeder C. fluminea. Although our focus is on gold and gold-core nanorods, the results obtained are expected to be translatable to other anisotropic materials. Broader Impacts :A multi-dimensional approach to broader impacts has been developed. This approach leverages existing programs at the three collaborating institutions while working to integrate efforts across the groups. Research dissemination and outreach. The PIs will collectively promote and disseminate the research results through existing community programs in Virginia, South Carolina, and Illinois. In addition, the results of this project will be broadcast to a broad technical audience through the traditional pathways of peer-reviewed publications and presentations at relevant conferences. Outreach efforts will target minority students in local high schools. Undergraduate research. Undergraduate research opportunities will be made available at all three collaborating institutions. Over the course of their careers, the PIs have collectively supported over 90 undergraduate researchersin their laboratories (a significant percentage of whom are members of historically under-represented groups in science and engineering) and this effort will provide additional undergraduate research opportunities. Undergraduate and graduate education. The research proposed in this effort combines nanomaterial synthesis and characterization techniques with colloidal physical principles in a manner that is not routinely found in undergraduate chemistry or environmental engineering curricula. Given this fact, all three PIs will take part in the development and production of classroom material (e.g., lectures, demonstrations) based upon this research that will be incorporated into courses at all three institutions.

CBET 1336353目前对刚性高度各向异性纳米结构的环境影响鲜为人知。具有高纵横比（AR =长度：直径）的纳米棒是具有许多潜在应用的令人兴奋的纳米材料类别。但是，迄今为止，只有有限的研究检查了这些细长的纳米材料的环境命运。由于已经明确表明各向异性会影响纳米棒与生物系统的相互作用，因此在这一领域缺乏工作尤其令人惊讶。推动目前努力的基本假设是，AR和表面化学的变化将改变河流系统中纳米棒命运的机制和动力学。 To test this hypothesis the PIs have developed a research plan that consists of four highly inter-related project tasks: In Task 1 we will synthesize gold nanorods with varying AR and we will then functionalize them using a range of environmentally relevant metal oxides (e.g., SiO2, gamma-Fe2O3, CeO2) to obtain a suite of nanomaterials that exhibit both shape and surface chemical heterogeneity.然后，这些纳米棒将用于研究纳米棒聚集（任务2），纳米棒沉积（任务3），并通过过滤器喂养双壳双壳类corbicula fluminea（任务4）摄取。完成这些任务的每一个都是一项重要的工作；但是，我们制定了一个凝聚力的研究计划，其中任何一项任务中获得的知识都用于帮助完善整体研究计划。智能优点：各向异性纳米颗粒是在不断扩展的形状和大小的各种形状和尺寸中生产的，量不断增加。目前，关于这些高度复杂的纳米材料的环境影响知之甚少。本文提出的努力将为描述材料各向异性如何决定环境矩阵中的纳米材料命运提供基本基础。这项工作的预期智力结果是i）系统检查纳米棒聚集动力学和分形维度，这是长宽比和溶液化学的函数（ii）通过系统变化（AR，表面化学）和收集器参数（例如，集合者的大小和表面粗糙度）在列研究中对沉积机制的描述； （iii）量化无处不在的滤光器C. fluminea对AR对纳米材料摄取的影响。尽管我们的重点是黄金和金核纳米棒，但预计获得的结果可以转换为其他各向异性材料。更广泛的影响：已经开发了一种多维方法来实现更广泛的影响。这种方法在三个合作机构中利用现有计划，同时努力整合跨小组的努力。研究传播和推广。 PI将通过弗吉尼亚州，南卡罗来纳州和伊利诺伊州的现有社区计划共同促进和传播研究结果。此外，该项目的结果将通过相关会议的同行评审出版物和演示文稿的传统途径向广​​泛的技术受众广播。外展工作将针对当地高中的少数族裔学生。本科研究。 本科研究机会将在所有三个合作机构中提供。在他们的职业生涯中，PIS共同支持了90多名本科研究人员的实验室（其中很大一部分是历史上代表性不足的科学与工程团体的成员），这项工作将提供额外的本科研究机会。本科和研究生教育。这项工作中提出的研究将纳米材料合成和表征技术与胶体物理原理结合在一起，这种方式在本科化学或环境工程课程中未常规发现。鉴于这一事实，所有三个PI都将基于这项研究的课堂材料（例如讲座，演示）的开发和生产，这些研究将纳入所有三个机构的课程中。