GOALI: SusChEM: An industrial-academic collaboration for high throughput discovery of base metal catalysts

目标：SusChEM：高通量发现贱金属催化剂的产学合作

• 批准号: 1265988
• 负责人: Paul Chirik
• 金额: $ 47.7万
• 依托单位: Princeton University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1265988&HistoricalAwards=false
• 关键词: GOALI; SusChEM; industrial; academic; collaboration

In this Grant Opportunities for Academic Liasons with Industry (GOALI) project funded by the Chemical Catalysis Program of the Chemistry Division, Professor Paul Chirik of Princeton University in full collaboration with Dr. Matt Tudge and his colleagues at Merck will develop base metal catalysts for drug discovery and production. The proposed research focuses on the asymmetric olefin hydrogenation reaction, a key transformation for the synthesis of single enantiomer organic molecules with biological activity. In collaboration with scientists at Merck, high throughput experimentation will be employed to identify metal-ligand combinations that exhibit high catalytic activity and enantioselectivity. Once suitable catalysts are identified, the Princeton group will independently synthesize and isolate these compounds and elucidate their electronic structure through a combination of spectroscopic, magnetic, structural and computational studies. The broader impacts of this research will include the exposure of undergraduate and graduate students to an industrial research setting at the Merck research site in Rahway, NJ. Chirality, the handedness of a molecule, often dictates the biological function of a molecule. Pharmaceuticals often contain chiral molecules and frequently require the challenging synthesis of a single hand of the compound of interest. Transition metal catalysts are known to catalyze reactions such as the hydrogenation of alkenes to produce the desired mirror image form. The proposed research seeks to discover metal catalysts that employ earth abundant and inexpensive elements such as iron and cobalt, a key innovation in sustainable sciences and technology. The project will also allow for integration of manufacturing principles into curricula for the classroom as well as provide undergraduate and graduate students a unique experience in an industrial laboratory.

在由化学部的化学催化计划资助的工业（守门员）项目的学术利亚斯的赠款机会中，普林斯顿大学的Paul Chirik教授与Matt Tudge博士及其默克公司的同事完全合作，将开发用于药物发现和生产的基准金属催化剂。拟议的研究集中于非对称烯烃氢化反应，这是合成具有生物学活性的单个对映体有机分子的关键转化。与默克公司的科学家合作，将采用高吞吐量实验来识别具有较高催化活性和对映选择性的金属配体组合。一旦确定了合适的催化剂，普林斯顿组将独立合成和分离这些化合物，并通过光谱，磁性，结构和计算研究的结合来阐明其电子结构。这项研究的更广泛的影响将包括在新泽西州拉赫韦的默克研究站点的工业研究环境中接触本科生和研究生。手性，分子的惯性，通常决定分子的生物学功能。药物通常含有手性分子，并且经常需要具有挑战性的一只感兴趣化合物的一只手。已知过渡金属催化剂可以催化反应，例如烯烃的氢化以产生所需的镜像形式。拟议的研究旨在发现采用地球丰富且廉价的元素（例如Iron and Cobalt）的金属催化剂，这是可持续科学和技术的关键创新。该项目还将允许将制造原则集成到课堂课程中，并为本科生和研究生提供工业实验室的独特经验。