Chiral Polycyclic Aromatic Architectures

手性多环芳香族结构

• 批准号: 1265507
• 负责人: Robert Pascal
• 金额: $ 51万
• 依托单位: Tulane University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1265507&HistoricalAwards=false
• 关键词: Chiral; Polycyclic; Aromatic; Architectures

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Robert A. Pascal, Jr., of the Department of Chemistry at Tulane University will explore the synthesis of new types of configurationally stable, chiral, polycyclic aromatic molecules. With the exception of the helicenes, such structures are quite uncommon and often difficult to synthesize, and their properties are largely unexplored. Four new classes of these compounds are proposed, with syntheses that are very short and easily modified for the tuning of shapes and properties. Their structural features ensure both high barriers to racemization and generally high thermal stability, and most of the molecules should be strongly luminescent. The resolved enantiomers of these compounds are expected to show very high optical rotations, strong circular dichroism, and strong circularly polarized luminescence, which in some cases may be modulated by external factors (temperature, light, etc.).The expected photophysical and chiroptical properties of this class of molecules make them candidates for application as organic electronic materials, particularly in display technologies or as electrooptic modulators. The expected structures may lend themselves to application as chiral catalysts or chiral hosts for separation technologies or medical diagnostics. The research itself will provide training for a variety of undergraduate and graduate scientists including women and underrepresented minorities, who will later enter into productive careers in science, engineering, and medicine.

在化学部化学综合计划资助的该项目中，杜兰大学化学系的小罗伯特·帕斯卡（Robert A. Pascal，Jr。 除了Helicenes外，此类结构非常罕见，而且通常很难合成，并且它们的性质在很大程度上没有探索。 提出了这些化合物的四个新类，其合成非常短且易于修饰，以调整形状和特性。它们的结构特征确保了高度障碍的种族化障碍和通常高的热稳定性，并且大多数分子都应非常发光。 这些化合物的解析对映异构体有望显示出非常高的光学旋转，强烈的循环二色性和强烈的循环极化发光，在某些情况下可能会通过外部因素（温度，光线等）进行调节。预期的光物理和手势性的分子的候选者候选人的竞争力是按构造材料或构造技术的，尤其是用于构造技术的技术。 预期的结构可以将自己作为手性催化剂或手性宿主应用于分离技术或医学诊断。 这项研究本身将为包括妇女和代表性不足的少数民族在内的各种本科生和研究生科学家提供培训，后来他们将从事科学，工程和医学的生产职业。

项目成果

An Exceptionally Close, Non‐Bonded Hydrogen–Hydrogen Contact with Strong Through‐Space Spin–Spin Coupling

异常紧密的非键合氢与强贯穿氢接触空间自旋自旋耦合

• DOI: 10.1002/anie.201712304
• 发表时间: 2018
• 期刊: Angewandte Chemie International Edition
• 作者: Xiao, Yonglong;Mague, Joel T.;Pascal, Jr., Robert A.
• 通讯作者: Pascal, Jr., Robert A.

in,in -Cyclophanes with Bridgehead Methyl Groups

具有桥头甲基的 in,in-环芳烃

• DOI: 10.1021/acs.orglett.8b00773
• 发表时间: 2018
• 期刊: Organic Letters
• 影响因子: 5.2
• 作者: Xiao, Yonglong;Mague, Joel T.;Pascal, Robert A.
• 通讯作者: Pascal, Robert A.

Multiple Isomers of a Small, Strained Phosphaphane: Multiple Isomers of a Small, Strained Phosphaphane

小的、应变的磷酸烷的多种异构体： 小的、应变的磷酸烷的多种异构体

• DOI: 10.1002/ejoc.201801106
• 发表时间: 2018
• 期刊: European Journal of Organic Chemistry
• 影响因子: 2.8
• 作者: Xiao, Yonglong;Mague, Joel T.;Pascal, Jr., Robert A.
• 通讯作者: Pascal, Jr., Robert A.