Collaborative Research: Chemical and Biological Quantum Nanosensors Based on Nanoparticle Molecules

合作研究：基于纳米颗粒分子的化学和生物量子纳米传感器

• 批准号: 1234957
• 负责人: Chuanbin Mao
• 金额: $ 36.31万
• 依托单位: University of Oklahoma Norman Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2016-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1234957&HistoricalAwards=false
• 关键词: Collaborative; Research; Chemical; Biological; Quantum

The research objective of this collaborative award is to explore chemical and biological quantum nanosensors by combining quantum coherence in hybrid systems consisting of semiconductor quantum dots and metallic nanoparticles with biomolecules' recognition functionalities. The unique feature of these sensors is their capabilities to utilize quantum coherence in such systems to convert the impact of introduction of biological molecules and chemical substances into noticeable and easily measurable physical quantities. The approach will include using collective properties of single and ensemble of quantum dot-metallic nanoparticle systems, such as molecular-type resonances and coherent dynamics of exciton-plasmons coupling, to detect biological and chemical agents with ultrahigh sensitivity. Optical signal transduction includes the way introduction of these agents changes the time delay that is coherently induced in the emission of the quantum dots when these hybrid systems interact with time-dependent laser fields. This research involves fabrication of nanochips consisting of arrays of semiconductor quantum dots and metallic nanoparticles separated from each other by dielectric materials or biomolecules. In such chips either the quantum dots or metallic nanoparticles are biologically functionalized for target detection. If successful, this research will link coherent nanoscience to life science applications and can advance the areas of quantum computers, nanodevices and sensors. Through the outreach program of this research, the high school students in Alabama will acquire first-hand experience of nanoscience through mini-workshops that offer meticulously designed experiments and interactive softwares. This research forms a platform for education of undergraduate and graduate students in interdisciplinary disciplines and provides them unique opportunities to investigate nanoparticle systems that harness biology to function, fabricate and test nano-systems with biological and physical applications, and become familiar with the diverse impacts of nanotechnology. Combination of these issues will prepare the ground for development of new curricula and programs and diversify the research activities in nanoscience.

该协作奖励的研究目标是通过在由半导体量子点和金属纳米颗粒与生物分子识别功能组成的混合系统中结合量子相干性来探索化学和生物量子纳米传感器。这些传感器的独特特征是它们在此类系统中利用量子相干性的能力将生物分子和化学物质引入的影响转换为明显且易于测量的物理量。该方法将包括使用量子点 - 金属纳米颗粒系统的单一和集合的集体特性，例如分子型共振和抗激元耦合的相干动力学，以检测具有超高敏感性的生物学和化学药物。光学信号转导包括这些试剂的引入的方式改变了当这些混合系统与时间依赖性激光场相互作用时，量子点发射中相干诱导的时间延迟。这项研究涉及纳米芯片的制造，这些纳米芯片由半导体量子点和金属纳米颗粒组成，它们通过介电材料或生物分子相互分离。在这样的芯片中，量子点或金属纳米颗粒在生物学上官能化以进行靶向检测。 如果成功，这项研究将将连贯的纳米科学与生命科学应用联系起来，并可以推进量子计算机，纳米电视和传感器的领域。通过这项研究的外展计划，阿拉巴马州的高中学生将通过提供精心设计的实验和互动软件的迷你工作工厂获得纳米科学的第一手经验。这项研究构成了跨学科学科的本科生和研究生教育的平台，并为他们提供了调查纳米颗粒系统的独特机会，这些纳米颗粒系统利用生物学来使用生物学和身体应用来运作，制造和测试纳米系统，并熟悉纳米技术的多样化影响。这些问题的结合将为开发新课程和计划的开发做准备，并使纳米科学的研究活动多样化。